Spatial predictions of Rhodesian Human African Trypanosomiasis (sleeping sickness) prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda
The continued northwards spread of Rhodesian sleeping sickness or Human African Trypanosomiasis (HAT) within Uganda is raising concerns of overlap with the Gambian form of the disease. Disease convergence would result in compromised diagnosis and treatment for HAT. Spatial determinants for HAT are p...
| Autores principales: | , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
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Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/61879 |
| _version_ | 1855518505868197888 |
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| author | Batchelor, N.A. Atkinson, P.M. Gething, P.W. Picozzi, K. Fèvre, Eric M. Kakembo, A.S. |
| author_browse | Atkinson, P.M. Batchelor, N.A. Fèvre, Eric M. Gething, P.W. Kakembo, A.S. Picozzi, K. |
| author_facet | Batchelor, N.A. Atkinson, P.M. Gething, P.W. Picozzi, K. Fèvre, Eric M. Kakembo, A.S. |
| author_sort | Batchelor, N.A. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The continued northwards spread of Rhodesian sleeping sickness or Human African Trypanosomiasis (HAT) within Uganda is raising concerns of overlap with the Gambian form of the disease. Disease convergence would result in compromised diagnosis and treatment for HAT. Spatial determinants for HAT are poorly understood across small areas. This study examines the relationships between Rhodesian HAT and several environmental, climatic and social factors in two newly affected districts, Kaberamaido and Dokolo. A one-step logistic regression analysis of HAT prevalence and a two-step logistic regression method permitted separate analysis of both HAT occurrence and HAT prevalence. Both the occurrence and prevalence of HAT were negatively correlated with distance to the closest livestock market in all models. The significance of distance to the closest livestock market strongly indicates that HAT may have been introduced to this previously unaffected area via the movement of infected, untreated livestock from endemic areas. This illustrates the importance of the animal reservoir in disease transmission, and highlights the need for trypanosomiasis control in livestock and the stringent implementation of regulations requiring the treatment of cattle prior to sale at livestock markets to prevent any further spread of Rhodesian HAT within Uganda. |
| format | Journal Article |
| id | CGSpace61879 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2009 |
| publishDateRange | 2009 |
| publishDateSort | 2009 |
| publisher | Public Library of Science |
| publisherStr | Public Library of Science |
| record_format | dspace |
| spelling | CGSpace618792024-05-23T19:41:36Z Spatial predictions of Rhodesian Human African Trypanosomiasis (sleeping sickness) prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda Batchelor, N.A. Atkinson, P.M. Gething, P.W. Picozzi, K. Fèvre, Eric M. Kakembo, A.S. trypanosomiasis disease control animal diseases zoonoses infectious diseases The continued northwards spread of Rhodesian sleeping sickness or Human African Trypanosomiasis (HAT) within Uganda is raising concerns of overlap with the Gambian form of the disease. Disease convergence would result in compromised diagnosis and treatment for HAT. Spatial determinants for HAT are poorly understood across small areas. This study examines the relationships between Rhodesian HAT and several environmental, climatic and social factors in two newly affected districts, Kaberamaido and Dokolo. A one-step logistic regression analysis of HAT prevalence and a two-step logistic regression method permitted separate analysis of both HAT occurrence and HAT prevalence. Both the occurrence and prevalence of HAT were negatively correlated with distance to the closest livestock market in all models. The significance of distance to the closest livestock market strongly indicates that HAT may have been introduced to this previously unaffected area via the movement of infected, untreated livestock from endemic areas. This illustrates the importance of the animal reservoir in disease transmission, and highlights the need for trypanosomiasis control in livestock and the stringent implementation of regulations requiring the treatment of cattle prior to sale at livestock markets to prevent any further spread of Rhodesian HAT within Uganda. 2009-12-15 2015-03-25T09:09:39Z 2015-03-25T09:09:39Z Journal Article https://hdl.handle.net/10568/61879 en Open Access Public Library of Science PLoS Neglected Tropical Diseases 2009;3(12):e563. |
| spellingShingle | trypanosomiasis disease control animal diseases zoonoses infectious diseases Batchelor, N.A. Atkinson, P.M. Gething, P.W. Picozzi, K. Fèvre, Eric M. Kakembo, A.S. Spatial predictions of Rhodesian Human African Trypanosomiasis (sleeping sickness) prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda |
| title | Spatial predictions of Rhodesian Human African Trypanosomiasis (sleeping sickness) prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda |
| title_full | Spatial predictions of Rhodesian Human African Trypanosomiasis (sleeping sickness) prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda |
| title_fullStr | Spatial predictions of Rhodesian Human African Trypanosomiasis (sleeping sickness) prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda |
| title_full_unstemmed | Spatial predictions of Rhodesian Human African Trypanosomiasis (sleeping sickness) prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda |
| title_short | Spatial predictions of Rhodesian Human African Trypanosomiasis (sleeping sickness) prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda |
| title_sort | spatial predictions of rhodesian human african trypanosomiasis sleeping sickness prevalence in kaberamaido and dokolo two newly affected districts of uganda |
| topic | trypanosomiasis disease control animal diseases zoonoses infectious diseases |
| url | https://hdl.handle.net/10568/61879 |
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