Re-evaluating the burden of rabies in Africa and Asia
OBJECTIVE: To quantify the public health and economic burden of endemic canine rabies in Africa and Asia. METHODS: Data from these regions were applied to a set of linked epidemiological and economic models. The human population at risk from endemic canine rabies was predicted using data on dog dens...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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FapUNIFESP
2005
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/61874 |
| _version_ | 1855518387728285696 |
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| author | Knobel, D.L. Cleaveland, S. Coleman, P.G. Fèvre, Eric M. Meltzer, M.I. Miranda, M.E. |
| author_browse | Cleaveland, S. Coleman, P.G. Fèvre, Eric M. Knobel, D.L. Meltzer, M.I. Miranda, M.E. |
| author_facet | Knobel, D.L. Cleaveland, S. Coleman, P.G. Fèvre, Eric M. Meltzer, M.I. Miranda, M.E. |
| author_sort | Knobel, D.L. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | OBJECTIVE: To quantify the public health and economic burden of endemic canine rabies in Africa and Asia. METHODS: Data from these regions were applied to a set of linked epidemiological and economic models. The human population at risk from endemic canine rabies was predicted using data on dog density, and human rabies deaths were estimated using a series of probability steps to determine the likelihood of clinical rabies developing in a person after being bitten by a dog suspected of having rabies. Model outputs on mortality and morbidity associated with rabies were used to calculate an improved disability-adjusted life year (DALY) score for the disease. The total societal cost incurred by the disease is presented. FINDINGS: Human mortality from endemic canine rabies was estimated to be 55 000 deaths per year (90% confidence interval (CI) = 24 000-93 000). Deaths due to rabies are responsible for 1.74 million DALYs lost each year (90% CI = 0.75-2.93). An additional 0.04 million DALYs are lost through morbidity and mortality following side-effects of nerve-tissue vaccines. The estimated annual cost of rabies is USD 583.5 million (90% CI = USD 540.1-626.3 million). Patient-borne costs for post-exposure treatment form the bulk of expenditure, accounting for nearly half the total costs of rabies. CONCLUSION: Rabies remains an important yet neglected disease in Africa and Asia. Disparities in the affordability and accessibility of post-exposure treatment and risks of exposure to rabid dogs result in a skewed distribution of the disease burden across society, with the major impact falling on those living in poor rural communities, in particular children. |
| format | Journal Article |
| id | CGSpace61874 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2005 |
| publishDateRange | 2005 |
| publishDateSort | 2005 |
| publisher | FapUNIFESP |
| publisherStr | FapUNIFESP |
| record_format | dspace |
| spelling | CGSpace618742025-12-08T10:29:22Z Re-evaluating the burden of rabies in Africa and Asia Knobel, D.L. Cleaveland, S. Coleman, P.G. Fèvre, Eric M. Meltzer, M.I. Miranda, M.E. animal diseases livestock OBJECTIVE: To quantify the public health and economic burden of endemic canine rabies in Africa and Asia. METHODS: Data from these regions were applied to a set of linked epidemiological and economic models. The human population at risk from endemic canine rabies was predicted using data on dog density, and human rabies deaths were estimated using a series of probability steps to determine the likelihood of clinical rabies developing in a person after being bitten by a dog suspected of having rabies. Model outputs on mortality and morbidity associated with rabies were used to calculate an improved disability-adjusted life year (DALY) score for the disease. The total societal cost incurred by the disease is presented. FINDINGS: Human mortality from endemic canine rabies was estimated to be 55 000 deaths per year (90% confidence interval (CI) = 24 000-93 000). Deaths due to rabies are responsible for 1.74 million DALYs lost each year (90% CI = 0.75-2.93). An additional 0.04 million DALYs are lost through morbidity and mortality following side-effects of nerve-tissue vaccines. The estimated annual cost of rabies is USD 583.5 million (90% CI = USD 540.1-626.3 million). Patient-borne costs for post-exposure treatment form the bulk of expenditure, accounting for nearly half the total costs of rabies. CONCLUSION: Rabies remains an important yet neglected disease in Africa and Asia. Disparities in the affordability and accessibility of post-exposure treatment and risks of exposure to rabid dogs result in a skewed distribution of the disease burden across society, with the major impact falling on those living in poor rural communities, in particular children. 2005-05 2015-03-25T09:09:39Z 2015-03-25T09:09:39Z Journal Article https://hdl.handle.net/10568/61874 en Open Access FapUNIFESP Knobel DL, Cleaveland S, Coleman PG, Fèvre EM, Meltzer MI, Miranda ME, Shaw A, Zinsstag J, Meslin FX. Re-evaluating the burden of rabies in Africa and Asia. Bull World Health Organ. 2005 May;83(5):360-8. Epub 2005 Jun 24. PMID: 15976877; PMCID: PMC2626230. |
| spellingShingle | animal diseases livestock Knobel, D.L. Cleaveland, S. Coleman, P.G. Fèvre, Eric M. Meltzer, M.I. Miranda, M.E. Re-evaluating the burden of rabies in Africa and Asia |
| title | Re-evaluating the burden of rabies in Africa and Asia |
| title_full | Re-evaluating the burden of rabies in Africa and Asia |
| title_fullStr | Re-evaluating the burden of rabies in Africa and Asia |
| title_full_unstemmed | Re-evaluating the burden of rabies in Africa and Asia |
| title_short | Re-evaluating the burden of rabies in Africa and Asia |
| title_sort | re evaluating the burden of rabies in africa and asia |
| topic | animal diseases livestock |
| url | https://hdl.handle.net/10568/61874 |
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