Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis
C57BL/6J mice are relatively resistant to trypanosomosis compared to BALB/c or A/J mice. Bloodstream trypanosomes are partly dependent on the host for lipid supply and the plasma lipid levels differ between resistant and susceptible mice. Furthermore, genes controlling plasma lipid levels are differ...
| Main Authors: | , , , , , , , |
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| Format: | Conference Paper |
| Language: | Inglés |
| Published: |
Tanzania Society for Animal Production
2006
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/51048 |
| _version_ | 1855534879837519872 |
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| author | Hassan, M. Agaba, Morris Bulimo, Wallace Noyes, H. Brass, A. Hinsley, T. Iraqi, F.A. Kemp, Stephen J. |
| author_browse | Agaba, Morris Brass, A. Bulimo, Wallace Hassan, M. Hinsley, T. Iraqi, F.A. Kemp, Stephen J. Noyes, H. |
| author_facet | Hassan, M. Agaba, Morris Bulimo, Wallace Noyes, H. Brass, A. Hinsley, T. Iraqi, F.A. Kemp, Stephen J. |
| author_sort | Hassan, M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | C57BL/6J mice are relatively resistant to trypanosomosis compared to BALB/c or A/J mice. Bloodstream trypanosomes are partly dependent on the host for lipid supply and the plasma lipid levels differ between resistant and susceptible mice. Furthermore, genes controlling plasma lipid levels are differentially expressed in resistant versus susceptible mice during trypanosomosis. Quantitative trait loci (QTL) studies have co-localised the QTLs for trypanotolerance and plasma HDL-cholesterol levels in mice. We hypothesise that plasma lipids have a role to play in trypanosomosis. We manipulated the plasma lipid levels of C57BL/6J, BALB/c and A/J mice and observed how the mice responded to Trypanosoma congolense infection. Significant differences in parasitaemia between the mice with higher and lower plasma lipid levels were observed only in the A/J (P<0.001). There was significant weight loss, following infection, in the mice with the higher plasma lipid levels. |
| format | Conference Paper |
| id | CGSpace51048 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2006 |
| publishDateRange | 2006 |
| publishDateSort | 2006 |
| publisher | Tanzania Society for Animal Production |
| publisherStr | Tanzania Society for Animal Production |
| record_format | dspace |
| spelling | CGSpace510482023-04-20T00:29:35Z Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis Hassan, M. Agaba, Morris Bulimo, Wallace Noyes, H. Brass, A. Hinsley, T. Iraqi, F.A. Kemp, Stephen J. trypanosomiasis trypanosoma congolense disease resistance blood plasma lipid content parasites loci laboratory animals mice cholesterol C57BL/6J mice are relatively resistant to trypanosomosis compared to BALB/c or A/J mice. Bloodstream trypanosomes are partly dependent on the host for lipid supply and the plasma lipid levels differ between resistant and susceptible mice. Furthermore, genes controlling plasma lipid levels are differentially expressed in resistant versus susceptible mice during trypanosomosis. Quantitative trait loci (QTL) studies have co-localised the QTLs for trypanotolerance and plasma HDL-cholesterol levels in mice. We hypothesise that plasma lipids have a role to play in trypanosomosis. We manipulated the plasma lipid levels of C57BL/6J, BALB/c and A/J mice and observed how the mice responded to Trypanosoma congolense infection. Significant differences in parasitaemia between the mice with higher and lower plasma lipid levels were observed only in the A/J (P<0.001). There was significant weight loss, following infection, in the mice with the higher plasma lipid levels. 2006 2014-10-31T06:22:01Z 2014-10-31T06:22:01Z Conference Paper https://hdl.handle.net/10568/51048 en Limited Access Tanzania Society for Animal Production |
| spellingShingle | trypanosomiasis trypanosoma congolense disease resistance blood plasma lipid content parasites loci laboratory animals mice cholesterol Hassan, M. Agaba, Morris Bulimo, Wallace Noyes, H. Brass, A. Hinsley, T. Iraqi, F.A. Kemp, Stephen J. Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis |
| title | Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis |
| title_full | Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis |
| title_fullStr | Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis |
| title_full_unstemmed | Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis |
| title_short | Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis |
| title_sort | role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis |
| topic | trypanosomiasis trypanosoma congolense disease resistance blood plasma lipid content parasites loci laboratory animals mice cholesterol |
| url | https://hdl.handle.net/10568/51048 |
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