Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract
Immune mechanisms against Cowdria ruminantium infection in livestock hosts are being investigated. This knowledge will be important for identification of protective antigens of C. ruminantium which will have application in the Development of vaccines against heartwater. T-cell Con-A supernatants inh...
| Main Authors: | , , , |
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| Format: | Conference Paper |
| Language: | Inglés |
| Published: |
ARC
1998
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/51046 |
| _version_ | 1855515764795113472 |
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| author | Mahan, S.M. Sileghem, M.R. Smith, G. Byrom, B. |
| author_browse | Byrom, B. Mahan, S.M. Sileghem, M.R. Smith, G. |
| author_facet | Mahan, S.M. Sileghem, M.R. Smith, G. Byrom, B. |
| author_sort | Mahan, S.M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Immune mechanisms against Cowdria ruminantium infection in livestock hosts are being investigated. This knowledge will be important for identification of protective antigens of C. ruminantium which will have application in the Development of vaccines against heartwater. T-cell Con-A supernatants inhibited the growth of C. ruminantium in-vitro. This effect was neither C. ruminantium strain or bovine endothelial cell type specific. As a follow up to these studies the cytokines responsible for this inhibition were investigated. Antibodies against bovine interferon (IFN) and tissue necrosis factor (TNF) were added to the infected cultures containing the T cell Con-A supernatants. Antibodies to IFN alone were able to block the inhibitory effect of these T cell supernatants. This data demonstrates the possible regulatory role of T cell in control of C. ruminantium infection. |
| format | Conference Paper |
| id | CGSpace51046 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1998 |
| publishDateRange | 1998 |
| publishDateSort | 1998 |
| publisher | ARC |
| publisherStr | ARC |
| record_format | dspace |
| spelling | CGSpace510462016-05-30T17:53:20Z Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract Mahan, S.M. Sileghem, M.R. Smith, G. Byrom, B. cowdria ruminantium growth disease control livestock vaccines antibodies Immune mechanisms against Cowdria ruminantium infection in livestock hosts are being investigated. This knowledge will be important for identification of protective antigens of C. ruminantium which will have application in the Development of vaccines against heartwater. T-cell Con-A supernatants inhibited the growth of C. ruminantium in-vitro. This effect was neither C. ruminantium strain or bovine endothelial cell type specific. As a follow up to these studies the cytokines responsible for this inhibition were investigated. Antibodies against bovine interferon (IFN) and tissue necrosis factor (TNF) were added to the infected cultures containing the T cell Con-A supernatants. Antibodies to IFN alone were able to block the inhibitory effect of these T cell supernatants. This data demonstrates the possible regulatory role of T cell in control of C. ruminantium infection. 1998 2014-10-31T06:22:01Z 2014-10-31T06:22:01Z Conference Paper https://hdl.handle.net/10568/51046 en Limited Access ARC |
| spellingShingle | cowdria ruminantium growth disease control livestock vaccines antibodies Mahan, S.M. Sileghem, M.R. Smith, G. Byrom, B. Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract |
| title | Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract |
| title_full | Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract |
| title_fullStr | Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract |
| title_full_unstemmed | Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract |
| title_short | Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract |
| title_sort | role of interferon gamma in control of cowdria ruminantium growth in vitro abstract |
| topic | cowdria ruminantium growth disease control livestock vaccines antibodies |
| url | https://hdl.handle.net/10568/51046 |
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