Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice
Genome-wide quantitative trait locus (QTL) mapping was used to evaluate the genetic basis of resistance to Helgmosomides polygyrus in an F2 cross of SWR and CBA mouse strains that are resistant and susceptible, respectively, to infection. 25 significant QTL affecting at least one of the resistance t...
| Autores principales: | , , , , , , , |
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| Formato: | Conference Paper |
| Lenguaje: | Inglés |
| Publicado: |
Institut National de la Recherche Agronomique
2002
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/51002 |
| _version_ | 1855528011646894080 |
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| author | Menge, D.M. Behnke, J.M. Iraqi, F.A. Lowe, A. Teale, A.J. Gibson, John P. Wakelin, D. Baker, R.L. |
| author_browse | Baker, R.L. Behnke, J.M. Gibson, John P. Iraqi, F.A. Lowe, A. Menge, D.M. Teale, A.J. Wakelin, D. |
| author_facet | Menge, D.M. Behnke, J.M. Iraqi, F.A. Lowe, A. Teale, A.J. Gibson, John P. Wakelin, D. Baker, R.L. |
| author_sort | Menge, D.M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Genome-wide quantitative trait locus (QTL) mapping was used to evaluate the genetic basis of resistance to Helgmosomides polygyrus in an F2 cross of SWR and CBA mouse strains that are resistant and susceptible, respectively, to infection. 25 significant QTL affecting at least one of the resistance traits i.e. faecal egg count at three measurement times, total worm count, granuloma score and immunoglobulin E and G1 titres. It was shown that 15 QTL were associated with more than one resistance trait, suggesting either pleiotropy or tight linkage as major mechanisms of the QTL for gastrointestinal resistance. The combined additive effects for the 5 QTL for total worm count accounted for about 60% of the difference between the parental lines. |
| format | Conference Paper |
| id | CGSpace51002 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2002 |
| publishDateRange | 2002 |
| publishDateSort | 2002 |
| publisher | Institut National de la Recherche Agronomique |
| publisherStr | Institut National de la Recherche Agronomique |
| record_format | dspace |
| spelling | CGSpace510022021-08-09T03:44:54Z Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice Menge, D.M. Behnke, J.M. Iraqi, F.A. Lowe, A. Teale, A.J. Gibson, John P. Wakelin, D. Baker, R.L. nematoda heligmosomoides polygyrus nematode infections animal diseases disease resistance biological differences digestive system diseases mice Genome-wide quantitative trait locus (QTL) mapping was used to evaluate the genetic basis of resistance to Helgmosomides polygyrus in an F2 cross of SWR and CBA mouse strains that are resistant and susceptible, respectively, to infection. 25 significant QTL affecting at least one of the resistance traits i.e. faecal egg count at three measurement times, total worm count, granuloma score and immunoglobulin E and G1 titres. It was shown that 15 QTL were associated with more than one resistance trait, suggesting either pleiotropy or tight linkage as major mechanisms of the QTL for gastrointestinal resistance. The combined additive effects for the 5 QTL for total worm count accounted for about 60% of the difference between the parental lines. 2002 2014-10-31T06:21:57Z 2014-10-31T06:21:57Z Conference Paper https://hdl.handle.net/10568/51002 en Limited Access Institut National de la Recherche Agronomique |
| spellingShingle | nematoda heligmosomoides polygyrus nematode infections animal diseases disease resistance biological differences digestive system diseases mice Menge, D.M. Behnke, J.M. Iraqi, F.A. Lowe, A. Teale, A.J. Gibson, John P. Wakelin, D. Baker, R.L. Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice |
| title | Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice |
| title_full | Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice |
| title_fullStr | Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice |
| title_full_unstemmed | Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice |
| title_short | Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice |
| title_sort | quantitative trait loci for resistance to gastro intestinal nematode infections in mice |
| topic | nematoda heligmosomoides polygyrus nematode infections animal diseases disease resistance biological differences digestive system diseases mice |
| url | https://hdl.handle.net/10568/51002 |
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