Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we?
Theileria parva, a tick-borne api-complexan protozoan parasite, causes East Coast fever (ECF) in cattle. Control of the disease by improved vaccination is believed to provide a sustainable solution. Class I MHC-restricted CD8+ cytotoxic T lymphocytes (CTL) directed at schizontinfected cells constitu...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Conference Paper |
| Lenguaje: | Inglés |
| Publicado: |
Tanzania Society for Animal Production
2006
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/50513 |
| _version_ | 1855531808929611776 |
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| author | Mwangi, David Miano Graham, S.P. Pelle, Roger Honda, Y. Tonukari, N.J. Yamage, I.M. Glew, E.J. Villiers, Etienne P. de Shah, Tushaar Bishop, Richard P. Abuya, E. Awino, Elias Gachanja, J. Luyai, A.E. Mbwika, F. Muthiani, A.M. Ndegwa, D.M. Njahira, Moses N. Nyanjui, J.K. Onono, F.O. Osaso, J. Saya, Rosemary M. Wildmann, C. Fraser, C.M. Maudlin, I. Gardner, M.J. Morzaria, S.P. Loosmore, S. Gilbert, S.C. Audonnet, J.C. Bruggen, P. van der Nene, Vishvanath M. Taracha, E.L.N. |
| author_browse | Abuya, E. Audonnet, J.C. Awino, Elias Bishop, Richard P. Bruggen, P. van der Fraser, C.M. Gachanja, J. Gardner, M.J. Gilbert, S.C. Glew, E.J. Graham, S.P. Honda, Y. Loosmore, S. Luyai, A.E. Maudlin, I. Mbwika, F. Morzaria, S.P. Muthiani, A.M. Mwangi, David Miano Ndegwa, D.M. Nene, Vishvanath M. Njahira, Moses N. Nyanjui, J.K. Onono, F.O. Osaso, J. Pelle, Roger Saya, Rosemary M. Shah, Tushaar Taracha, E.L.N. Tonukari, N.J. Villiers, Etienne P. de Wildmann, C. Yamage, I.M. |
| author_facet | Mwangi, David Miano Graham, S.P. Pelle, Roger Honda, Y. Tonukari, N.J. Yamage, I.M. Glew, E.J. Villiers, Etienne P. de Shah, Tushaar Bishop, Richard P. Abuya, E. Awino, Elias Gachanja, J. Luyai, A.E. Mbwika, F. Muthiani, A.M. Ndegwa, D.M. Njahira, Moses N. Nyanjui, J.K. Onono, F.O. Osaso, J. Saya, Rosemary M. Wildmann, C. Fraser, C.M. Maudlin, I. Gardner, M.J. Morzaria, S.P. Loosmore, S. Gilbert, S.C. Audonnet, J.C. Bruggen, P. van der Nene, Vishvanath M. Taracha, E.L.N. |
| author_sort | Mwangi, David Miano |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Theileria parva, a tick-borne api-complexan protozoan parasite, causes East Coast fever (ECF) in cattle. Control of the disease by improved vaccination is believed to provide a sustainable solution. Class I MHC-restricted CD8+ cytotoxic T lymphocytes (CTL) directed at schizontinfected cells constitute the effector immune mechanism against ECF in cattle recovering from a single or multiple infection(s). Schizont antigens recognised by CTL are therefore prime vaccine candidates. We describe a rational approach used to identify 8 CTL target antigens as vaccine candidates. The genes encoding the target antigens have been engineered in plasmid DNA and viral vectors for evaluating their immunogenicity and efficacy in cattle. In a preliminary trial, five of the candidate vaccines demonstrated the capacity to induce CTL responses that correlated with survival and reduced disease severity following a lethal parasite challenge. |
| format | Conference Paper |
| id | CGSpace50513 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2006 |
| publishDateRange | 2006 |
| publishDateSort | 2006 |
| publisher | Tanzania Society for Animal Production |
| publisherStr | Tanzania Society for Animal Production |
| record_format | dspace |
| spelling | CGSpace505132024-03-06T10:16:43Z Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we? Mwangi, David Miano Graham, S.P. Pelle, Roger Honda, Y. Tonukari, N.J. Yamage, I.M. Glew, E.J. Villiers, Etienne P. de Shah, Tushaar Bishop, Richard P. Abuya, E. Awino, Elias Gachanja, J. Luyai, A.E. Mbwika, F. Muthiani, A.M. Ndegwa, D.M. Njahira, Moses N. Nyanjui, J.K. Onono, F.O. Osaso, J. Saya, Rosemary M. Wildmann, C. Fraser, C.M. Maudlin, I. Gardner, M.J. Morzaria, S.P. Loosmore, S. Gilbert, S.C. Audonnet, J.C. Bruggen, P. van der Nene, Vishvanath M. Taracha, E.L.N. cattle east coast fever genomes immunity disease resistance hosts theileria parva vaccines parasites antigens technology immunogenetics Theileria parva, a tick-borne api-complexan protozoan parasite, causes East Coast fever (ECF) in cattle. Control of the disease by improved vaccination is believed to provide a sustainable solution. Class I MHC-restricted CD8+ cytotoxic T lymphocytes (CTL) directed at schizontinfected cells constitute the effector immune mechanism against ECF in cattle recovering from a single or multiple infection(s). Schizont antigens recognised by CTL are therefore prime vaccine candidates. We describe a rational approach used to identify 8 CTL target antigens as vaccine candidates. The genes encoding the target antigens have been engineered in plasmid DNA and viral vectors for evaluating their immunogenicity and efficacy in cattle. In a preliminary trial, five of the candidate vaccines demonstrated the capacity to induce CTL responses that correlated with survival and reduced disease severity following a lethal parasite challenge. 2006 2014-10-31T06:09:19Z 2014-10-31T06:09:19Z Conference Paper https://hdl.handle.net/10568/50513 en Limited Access Tanzania Society for Animal Production |
| spellingShingle | cattle east coast fever genomes immunity disease resistance hosts theileria parva vaccines parasites antigens technology immunogenetics Mwangi, David Miano Graham, S.P. Pelle, Roger Honda, Y. Tonukari, N.J. Yamage, I.M. Glew, E.J. Villiers, Etienne P. de Shah, Tushaar Bishop, Richard P. Abuya, E. Awino, Elias Gachanja, J. Luyai, A.E. Mbwika, F. Muthiani, A.M. Ndegwa, D.M. Njahira, Moses N. Nyanjui, J.K. Onono, F.O. Osaso, J. Saya, Rosemary M. Wildmann, C. Fraser, C.M. Maudlin, I. Gardner, M.J. Morzaria, S.P. Loosmore, S. Gilbert, S.C. Audonnet, J.C. Bruggen, P. van der Nene, Vishvanath M. Taracha, E.L.N. Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we? |
| title | Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we? |
| title_full | Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we? |
| title_fullStr | Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we? |
| title_full_unstemmed | Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we? |
| title_short | Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we? |
| title_sort | exploiting host immunity and parasite genomics to develop a robust sub unit vaccine against east coast fever in cattle where are we |
| topic | cattle east coast fever genomes immunity disease resistance hosts theileria parva vaccines parasites antigens technology immunogenetics |
| url | https://hdl.handle.net/10568/50513 |
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