Bovine alloreactive cytotoxic T cells
The target antigens recognized by bovine alloreactive cytotoxic T cells are discussed and compared with serologically defined bovine major histocompatibility complex (MHC) products which make up the bovine lymphocyte antigen (BoLA) system. The role of MHC products in T-cell function in other specie...
| Main Authors: | , , , , , |
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| Format: | Conference Paper |
| Language: | Inglés |
| Published: |
Cambridge University Press
1986
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/50237 |
| _version_ | 1855537186892414976 |
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| author | Teale, A.J. Morrison, W. Ivan Spooner, R.L. Goddeeris, Bruno M. Groocock, C.M. Stagg, D.A. |
| author_browse | Goddeeris, Bruno M. Groocock, C.M. Morrison, W. Ivan Spooner, R.L. Stagg, D.A. Teale, A.J. |
| author_facet | Teale, A.J. Morrison, W. Ivan Spooner, R.L. Goddeeris, Bruno M. Groocock, C.M. Stagg, D.A. |
| author_sort | Teale, A.J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The target antigens recognized by bovine alloreactive cytotoxic T cells are discussed and compared with serologically defined bovine major histocompatibility complex (MHC) products which make up the bovine lymphocyte antigen (BoLA) system. The role of MHC products in T-cell function in other species is reviewed with particular emphasis on the use of cytotoxic T cells in the characterization of human and murine MHC products and in the Development of cytotoxic T-cell technology in general. In the bovine system, serologically defined BoLA-A-locus products w8 and w11 are closely associated with, or identical to, the target determinants for cytotoxic T cells generated in vitro in peripheral blood mononuclear cells (PMB) of unprimed w8- and w11-negative cattle cocultured with w8/w11 PMB. There was little evidence of cytotoxicity directed against other products of the MHC. In similar studies of the specificity of cytotoxic T cells generated against PMB carrying the serologically defined specificity w6 and its subgroups, cytotoxicity could be detected with correlated with distribution of the subgroups of w6 on target cells, but not with w6 itself. The generation and specificity of cytotoxic T cells in cocultures of w8/w11 responder PMB and w8/w11 stimulator PMB were also examined. In some cases, cytotoxic T cells were generated and their target specificity suggested that products of a second cell-mediated lympholysis-controlling locus in cattle were being detected. The nature of these products is not known. |
| format | Conference Paper |
| id | CGSpace50237 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1986 |
| publishDateRange | 1986 |
| publishDateSort | 1986 |
| publisher | Cambridge University Press |
| publisherStr | Cambridge University Press |
| record_format | dspace |
| spelling | CGSpace502372024-01-17T12:58:34Z Bovine alloreactive cytotoxic T cells Teale, A.J. Morrison, W. Ivan Spooner, R.L. Goddeeris, Bruno M. Groocock, C.M. Stagg, D.A. cattle lymphocytes The target antigens recognized by bovine alloreactive cytotoxic T cells are discussed and compared with serologically defined bovine major histocompatibility complex (MHC) products which make up the bovine lymphocyte antigen (BoLA) system. The role of MHC products in T-cell function in other species is reviewed with particular emphasis on the use of cytotoxic T cells in the characterization of human and murine MHC products and in the Development of cytotoxic T-cell technology in general. In the bovine system, serologically defined BoLA-A-locus products w8 and w11 are closely associated with, or identical to, the target determinants for cytotoxic T cells generated in vitro in peripheral blood mononuclear cells (PMB) of unprimed w8- and w11-negative cattle cocultured with w8/w11 PMB. There was little evidence of cytotoxicity directed against other products of the MHC. In similar studies of the specificity of cytotoxic T cells generated against PMB carrying the serologically defined specificity w6 and its subgroups, cytotoxicity could be detected with correlated with distribution of the subgroups of w6 on target cells, but not with w6 itself. The generation and specificity of cytotoxic T cells in cocultures of w8/w11 responder PMB and w8/w11 stimulator PMB were also examined. In some cases, cytotoxic T cells were generated and their target specificity suggested that products of a second cell-mediated lympholysis-controlling locus in cattle were being detected. The nature of these products is not known. 1986 2014-10-31T06:08:58Z 2014-10-31T06:08:58Z Conference Paper https://hdl.handle.net/10568/50237 en Limited Access Cambridge University Press |
| spellingShingle | cattle lymphocytes Teale, A.J. Morrison, W. Ivan Spooner, R.L. Goddeeris, Bruno M. Groocock, C.M. Stagg, D.A. Bovine alloreactive cytotoxic T cells |
| title | Bovine alloreactive cytotoxic T cells |
| title_full | Bovine alloreactive cytotoxic T cells |
| title_fullStr | Bovine alloreactive cytotoxic T cells |
| title_full_unstemmed | Bovine alloreactive cytotoxic T cells |
| title_short | Bovine alloreactive cytotoxic T cells |
| title_sort | bovine alloreactive cytotoxic t cells |
| topic | cattle lymphocytes |
| url | https://hdl.handle.net/10568/50237 |
| work_keys_str_mv | AT tealeaj bovinealloreactivecytotoxictcells AT morrisonwivan bovinealloreactivecytotoxictcells AT spoonerrl bovinealloreactivecytotoxictcells AT goddeerisbrunom bovinealloreactivecytotoxictcells AT groocockcm bovinealloreactivecytotoxictcells AT staggda bovinealloreactivecytotoxictcells |