Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues
The BM86 antigen, originally identified in Rhipicephalus (Boophilus) microplus, is the basis of the only commercialized anti-tick vaccine. The long-term goal of our study is to improve BM86 based vaccines by induction of high levels of tick gut binding antibodies that are also cross-reactive with a...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2009
|
| Acceso en línea: | https://hdl.handle.net/10568/381 |
| _version_ | 1855520546171650048 |
|---|---|
| author | Kopp, N. Díaz, D. Amacker, M. Odongo, David O. Beier, K. Nitsch, C. Bishop, Richard P. Daubenberger, C.A. |
| author_browse | Amacker, M. Beier, K. Bishop, Richard P. Daubenberger, C.A. Díaz, D. Kopp, N. Nitsch, C. Odongo, David O. |
| author_facet | Kopp, N. Díaz, D. Amacker, M. Odongo, David O. Beier, K. Nitsch, C. Bishop, Richard P. Daubenberger, C.A. |
| author_sort | Kopp, N. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The BM86 antigen, originally identified in Rhipicephalus (Boophilus) microplus, is the basis of the only commercialized anti-tick vaccine. The long-term goal of our study is to improve BM86 based vaccines by induction of high levels of tick gut binding antibodies that are also cross-reactive with a range of BM86 homologues expressed in other important tick species. Here we have used a BD86 derived synthetic peptide, BD86-3, to raise a series of mouse monoclonal antibodies. One of these mAbs, named 12.1, recognized BM86 homologues in immuno-histochemical analyses in four out of five tick species including R. (B.) microplus, Rhipicephalus (Boophilus) decoloratus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus. Our results indicate that broadly cross-reactive tick gut binding antibodies can be induced after immunization with a synthetic peptide derived from the protein BD86. |
| format | Journal Article |
| id | CGSpace381 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2009 |
| publishDateRange | 2009 |
| publishDateSort | 2009 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace3812024-03-03T19:19:19Z Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues Kopp, N. Díaz, D. Amacker, M. Odongo, David O. Beier, K. Nitsch, C. Bishop, Richard P. Daubenberger, C.A. The BM86 antigen, originally identified in Rhipicephalus (Boophilus) microplus, is the basis of the only commercialized anti-tick vaccine. The long-term goal of our study is to improve BM86 based vaccines by induction of high levels of tick gut binding antibodies that are also cross-reactive with a range of BM86 homologues expressed in other important tick species. Here we have used a BD86 derived synthetic peptide, BD86-3, to raise a series of mouse monoclonal antibodies. One of these mAbs, named 12.1, recognized BM86 homologues in immuno-histochemical analyses in four out of five tick species including R. (B.) microplus, Rhipicephalus (Boophilus) decoloratus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus. Our results indicate that broadly cross-reactive tick gut binding antibodies can be induced after immunization with a synthetic peptide derived from the protein BD86. 2009-12 2010-01-12T05:47:34Z 2010-01-12T05:47:34Z Journal Article https://hdl.handle.net/10568/381 en Limited Access Elsevier Kopp, N.; Diaz, D.; Amacker, M.; Odongo, D.O.; Beier, K.; Nitsch, C.; Bishop, R.P.; Daubenberger, C.A. 2009. Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues Vaccine. v. 28(1). p. 261-269. |
| spellingShingle | Kopp, N. Díaz, D. Amacker, M. Odongo, David O. Beier, K. Nitsch, C. Bishop, Richard P. Daubenberger, C.A. Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues |
| title | Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues |
| title_full | Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues |
| title_fullStr | Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues |
| title_full_unstemmed | Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues |
| title_short | Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues |
| title_sort | identification of a synthetic peptide inducing cross reactive antibodies binding to rhipicephalus boophilus decoloratus rhipicephalus boophilus microplus hyalomma anatolicum anatolicum and rhipicephalus appendiculatus bm86 homologues |
| url | https://hdl.handle.net/10568/381 |
| work_keys_str_mv | AT koppn identificationofasyntheticpeptideinducingcrossreactiveantibodiesbindingtorhipicephalusboophilusdecoloratusrhipicephalusboophilusmicroplushyalommaanatolicumanatolicumandrhipicephalusappendiculatusbm86homologues AT diazd identificationofasyntheticpeptideinducingcrossreactiveantibodiesbindingtorhipicephalusboophilusdecoloratusrhipicephalusboophilusmicroplushyalommaanatolicumanatolicumandrhipicephalusappendiculatusbm86homologues AT amackerm identificationofasyntheticpeptideinducingcrossreactiveantibodiesbindingtorhipicephalusboophilusdecoloratusrhipicephalusboophilusmicroplushyalommaanatolicumanatolicumandrhipicephalusappendiculatusbm86homologues AT odongodavido identificationofasyntheticpeptideinducingcrossreactiveantibodiesbindingtorhipicephalusboophilusdecoloratusrhipicephalusboophilusmicroplushyalommaanatolicumanatolicumandrhipicephalusappendiculatusbm86homologues AT beierk identificationofasyntheticpeptideinducingcrossreactiveantibodiesbindingtorhipicephalusboophilusdecoloratusrhipicephalusboophilusmicroplushyalommaanatolicumanatolicumandrhipicephalusappendiculatusbm86homologues AT nitschc identificationofasyntheticpeptideinducingcrossreactiveantibodiesbindingtorhipicephalusboophilusdecoloratusrhipicephalusboophilusmicroplushyalommaanatolicumanatolicumandrhipicephalusappendiculatusbm86homologues AT bishoprichardp identificationofasyntheticpeptideinducingcrossreactiveantibodiesbindingtorhipicephalusboophilusdecoloratusrhipicephalusboophilusmicroplushyalommaanatolicumanatolicumandrhipicephalusappendiculatusbm86homologues AT daubenbergerca identificationofasyntheticpeptideinducingcrossreactiveantibodiesbindingtorhipicephalusboophilusdecoloratusrhipicephalusboophilusmicroplushyalommaanatolicumanatolicumandrhipicephalusappendiculatusbm86homologues |