Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity
Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized against the parasite by infection and treatment, but immunity is partially strain specific. Available data indicate that CD8+ T lymphocyte respon...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/3780 |
| _version_ | 1855522659894296576 |
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| author | Pelle, Roger Graham, S.P. Njahira, Moses N. Osaso, J. Saya, Rosemary M. Odongo, David O. Toye, Philip G. Spooner, P.R. Musoke, A.J. Mwangi, David Miano Taracha, E.L.N. Morrison, W. Ivan Weir, W. Silva, J. Bishop, Richard P. |
| author_browse | Bishop, Richard P. Graham, S.P. Morrison, W. Ivan Musoke, A.J. Mwangi, David Miano Njahira, Moses N. Odongo, David O. Osaso, J. Pelle, Roger Saya, Rosemary M. Silva, J. Spooner, P.R. Taracha, E.L.N. Toye, Philip G. Weir, W. |
| author_facet | Pelle, Roger Graham, S.P. Njahira, Moses N. Osaso, J. Saya, Rosemary M. Odongo, David O. Toye, Philip G. Spooner, P.R. Musoke, A.J. Mwangi, David Miano Taracha, E.L.N. Morrison, W. Ivan Weir, W. Silva, J. Bishop, Richard P. |
| author_sort | Pelle, Roger |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized against the parasite by infection and treatment, but immunity is partially strain specific. Available data indicate that CD8+ T lymphocyte responses mediate protection and, recently, several parasite antigens recognised by CD8+ T cells have been identified. This study set out to determine the nature and extent of polymorphism in two of these antigens, Tp1 and Tp2, which contain defined CD8+ T-cell epitopes, and to analyse the sequences for evidence of selection. |
| format | Journal Article |
| id | CGSpace3780 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2011 |
| publishDateRange | 2011 |
| publishDateSort | 2011 |
| publisher | Public Library of Science |
| publisherStr | Public Library of Science |
| record_format | dspace |
| spelling | CGSpace37802024-03-06T10:16:43Z Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity Pelle, Roger Graham, S.P. Njahira, Moses N. Osaso, J. Saya, Rosemary M. Odongo, David O. Toye, Philip G. Spooner, P.R. Musoke, A.J. Mwangi, David Miano Taracha, E.L.N. Morrison, W. Ivan Weir, W. Silva, J. Bishop, Richard P. animal diseases cattle Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized against the parasite by infection and treatment, but immunity is partially strain specific. Available data indicate that CD8+ T lymphocyte responses mediate protection and, recently, several parasite antigens recognised by CD8+ T cells have been identified. This study set out to determine the nature and extent of polymorphism in two of these antigens, Tp1 and Tp2, which contain defined CD8+ T-cell epitopes, and to analyse the sequences for evidence of selection. 2011-04-29 2011-05-30T06:53:39Z 2011-05-30T06:53:39Z Journal Article https://hdl.handle.net/10568/3780 en Open Access Public Library of Science Pelle, R., Graham, S.P., Njahira, M.N., Osaso, J., Saya, R.M., Odongo, D.O., Toye, P.G., Spooner, P.R., Musoke, A.J., Mwangi, D.M., Taracha, E.L.N., Morrison, W. Ivan, Weir, W., Silva, J.C., Bishop, R.P. 2011. Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity. PLoS ONE 6(4):e19015. |
| spellingShingle | animal diseases cattle Pelle, Roger Graham, S.P. Njahira, Moses N. Osaso, J. Saya, Rosemary M. Odongo, David O. Toye, Philip G. Spooner, P.R. Musoke, A.J. Mwangi, David Miano Taracha, E.L.N. Morrison, W. Ivan Weir, W. Silva, J. Bishop, Richard P. Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity |
| title | Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity |
| title_full | Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity |
| title_fullStr | Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity |
| title_full_unstemmed | Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity |
| title_short | Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity |
| title_sort | two theileria parva cd8 t cell antigen genes are more variable in buffalo than cattle parasites but differ in pattern of sequence diversity |
| topic | animal diseases cattle |
| url | https://hdl.handle.net/10568/3780 |
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