Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice
A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens in...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Cambridge University Press
2010
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/358 |
| _version_ | 1855517453441826816 |
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| author | Behnke, J.M. Menge, D.M. Nagda, S.M. Noyes, H. Iraqi, F.A. Kemp, Stephen J. Mugambi, R.J.M. Baker, R.L. Wakelin, D. Gibson, John P. |
| author_browse | Baker, R.L. Behnke, J.M. Gibson, John P. Iraqi, F.A. Kemp, Stephen J. Menge, D.M. Mugambi, R.J.M. Nagda, S.M. Noyes, H. Wakelin, D. |
| author_facet | Behnke, J.M. Menge, D.M. Nagda, S.M. Noyes, H. Iraqi, F.A. Kemp, Stephen J. Mugambi, R.J.M. Baker, R.L. Wakelin, D. Gibson, John P. |
| author_sort | Behnke, J.M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found on both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease 1 (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and 11 (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and 11 (Hbnr15). Our data emphasize that the control of resistance to H. bakeri is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships. |
| format | Journal Article |
| id | CGSpace358 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2010 |
| publishDateRange | 2010 |
| publishDateSort | 2010 |
| publisher | Cambridge University Press |
| publisherStr | Cambridge University Press |
| record_format | dspace |
| spelling | CGSpace3582024-11-15T08:52:11Z Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice Behnke, J.M. Menge, D.M. Nagda, S.M. Noyes, H. Iraqi, F.A. Kemp, Stephen J. Mugambi, R.J.M. Baker, R.L. Wakelin, D. Gibson, John P. disease resistance infectious diseases parasitology A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found on both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease 1 (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and 11 (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and 11 (Hbnr15). Our data emphasize that the control of resistance to H. bakeri is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships. 2010-02 2010-01-05T18:20:16Z 2010-01-05T18:20:16Z Journal Article https://hdl.handle.net/10568/358 en Limited Access Cambridge University Press Behnke, J.M.; Menge, D.M.; Nagda, S.; Noyes, H.; Iraqi, F.A.; Kemp, S.J.; Mugambi, R.J.M.; Baker, R.L.; Wakelin, D.; Gibson, J.P. 2010. Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice. Parasitology. 137(2): 311-320 |
| spellingShingle | disease resistance infectious diseases parasitology Behnke, J.M. Menge, D.M. Nagda, S.M. Noyes, H. Iraqi, F.A. Kemp, Stephen J. Mugambi, R.J.M. Baker, R.L. Wakelin, D. Gibson, John P. Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice |
| title | Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice |
| title_full | Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice |
| title_fullStr | Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice |
| title_full_unstemmed | Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice |
| title_short | Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice |
| title_sort | quantitative trait loci for resistance to heligmosomoides bakeri and associated immunological and pathological traits in mice comparison of loci on chromosomes 5 8 and 11 in f2 and f6 7 inter cross lines of mice |
| topic | disease resistance infectious diseases parasitology |
| url | https://hdl.handle.net/10568/358 |
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