Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment?
Murine models have suggested that CD8 T cells might play a major parasite-promoting role in African trypanosomiasis. To assess the role of these cells in a natural host environment, we have depleted CD8 cells from Boran cattle in vivo and subsequently infected these animals with Trypanosoma congolen...
| Main Authors: | , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Wiley
1995
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/35336 |
| _version_ | 1855521501913022464 |
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| author | Sileghem, M.R. Naessens, Jan |
| author_browse | Naessens, Jan Sileghem, M.R. |
| author_facet | Sileghem, M.R. Naessens, Jan |
| author_sort | Sileghem, M.R. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Murine models have suggested that CD8 T cells might play a major parasite-promoting role in African trypanosomiasis. To assess the role of these cells in a natural host environment, we have depleted CD8 cells from Boran cattle in vivo and subsequently infected these animals with Trypanosoma congolense by tsetse fly challenge. Following administration of a mouse monoclonal anti-bovine CD8 antibody, we have been able to achieve a depletion of more than 99.9% in peripheral blood, spleen, prescapular lymph nodes, prefemoral lymph nodes, mesenteric lymph nodes and Peyer's patches. Depletion could be maintained over a 4-5-week infection period. Despite the almost total absence of CD8 cells, no effect whatsoever was observed on parasitemia. In addition, anemia, which is the main factor determining the mean survival time in cattle was not affected by the CD8 depletion. |
| format | Journal Article |
| id | CGSpace35336 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1995 |
| publishDateRange | 1995 |
| publishDateSort | 1995 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace353362024-08-27T12:27:43Z Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment? Sileghem, M.R. Naessens, Jan disease control animal diseases trypanosomiasis Murine models have suggested that CD8 T cells might play a major parasite-promoting role in African trypanosomiasis. To assess the role of these cells in a natural host environment, we have depleted CD8 cells from Boran cattle in vivo and subsequently infected these animals with Trypanosoma congolense by tsetse fly challenge. Following administration of a mouse monoclonal anti-bovine CD8 antibody, we have been able to achieve a depletion of more than 99.9% in peripheral blood, spleen, prescapular lymph nodes, prefemoral lymph nodes, mesenteric lymph nodes and Peyer's patches. Depletion could be maintained over a 4-5-week infection period. Despite the almost total absence of CD8 cells, no effect whatsoever was observed on parasitemia. In addition, anemia, which is the main factor determining the mean survival time in cattle was not affected by the CD8 depletion. 1995-07 2014-04-14T10:56:02Z 2014-04-14T10:56:02Z Journal Article https://hdl.handle.net/10568/35336 en Limited Access Wiley Sileghem, M. and Naessens, J. 1995. Are CD8 T cells involved in control of african trypanosomiasis in a natural host environment? European Journal of Immunology 25(7): 1965-1971. |
| spellingShingle | disease control animal diseases trypanosomiasis Sileghem, M.R. Naessens, Jan Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment? |
| title | Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment? |
| title_full | Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment? |
| title_fullStr | Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment? |
| title_full_unstemmed | Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment? |
| title_short | Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment? |
| title_sort | are cd8 t cells involved in control of african trypanosomiasis in a natural host environment |
| topic | disease control animal diseases trypanosomiasis |
| url | https://hdl.handle.net/10568/35336 |
| work_keys_str_mv | AT sileghemmr arecd8tcellsinvolvedincontrolofafricantrypanosomiasisinanaturalhostenvironment AT naessensjan arecd8tcellsinvolvedincontrolofafricantrypanosomiasisinanaturalhostenvironment |