Comparison of vaccination strategies for the control of dog rabies in Machakos District, Kenya
Demographic and epidemiological field data were used in a determinstic model to describe dog rabies transmission in Machakos District, Kenya and to predict the impact of potential vaccination strategies for its control. The basic reproduction number (R0) was estimated to be 2.44 (1.52-3.36, 95% conf...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Cambridge University Press
2002
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/35329 |
| _version_ | 1855540495969681408 |
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| author | Kitala, P.M. McDermott, John J. Coleman, P.G. Dye, C. |
| author_browse | Coleman, P.G. Dye, C. Kitala, P.M. McDermott, John J. |
| author_facet | Kitala, P.M. McDermott, John J. Coleman, P.G. Dye, C. |
| author_sort | Kitala, P.M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Demographic and epidemiological field data were used in a determinstic model to describe dog rabies transmission in Machakos District, Kenya and to predict the impact of potential vaccination strategies for its control. The basic reproduction number (R0) was estimated to be 2.44 (1.52-3.36, 95% confidence limits). There were three key model predictions. The first was that a threshold dog density (KT) of 4.5 dogs km-2 (3.8-5.2 dogs km-2, 95% confidence limits) was required to maintain transmission. The second was that the estimated annual vaccination rate of 24% failed to decrease incidence and actually increased the stability of transmission and may be counter-productive. Thirdly, to control rabies, it was predicted that 59% (34%-70%, 95% confidence limits) of dogs should be vaccinated at any one time. This requires approximately 70% coverage for annual but only 60% coverage for semi-annual vaccination campaigns. Community-level vaccination trials are needed to test these predictions. |
| format | Journal Article |
| id | CGSpace35329 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2002 |
| publishDateRange | 2002 |
| publishDateSort | 2002 |
| publisher | Cambridge University Press |
| publisherStr | Cambridge University Press |
| record_format | dspace |
| spelling | CGSpace353292024-11-15T08:53:06Z Comparison of vaccination strategies for the control of dog rabies in Machakos District, Kenya Kitala, P.M. McDermott, John J. Coleman, P.G. Dye, C. vaccination disease control Demographic and epidemiological field data were used in a determinstic model to describe dog rabies transmission in Machakos District, Kenya and to predict the impact of potential vaccination strategies for its control. The basic reproduction number (R0) was estimated to be 2.44 (1.52-3.36, 95% confidence limits). There were three key model predictions. The first was that a threshold dog density (KT) of 4.5 dogs km-2 (3.8-5.2 dogs km-2, 95% confidence limits) was required to maintain transmission. The second was that the estimated annual vaccination rate of 24% failed to decrease incidence and actually increased the stability of transmission and may be counter-productive. Thirdly, to control rabies, it was predicted that 59% (34%-70%, 95% confidence limits) of dogs should be vaccinated at any one time. This requires approximately 70% coverage for annual but only 60% coverage for semi-annual vaccination campaigns. Community-level vaccination trials are needed to test these predictions. 2002-08 2014-04-14T10:56:00Z 2014-04-14T10:56:00Z Journal Article https://hdl.handle.net/10568/35329 en Open Access Cambridge University Press Kitala, P.M., McDermott, J.J., Coleman, P.G. and Dye, C. 2002. Comparison of vaccination strategies for the control of dog rabies in Machakos District, Kenya. Epidemiology and Infection 129(1): 215-222. |
| spellingShingle | vaccination disease control Kitala, P.M. McDermott, John J. Coleman, P.G. Dye, C. Comparison of vaccination strategies for the control of dog rabies in Machakos District, Kenya |
| title | Comparison of vaccination strategies for the control of dog rabies in Machakos District, Kenya |
| title_full | Comparison of vaccination strategies for the control of dog rabies in Machakos District, Kenya |
| title_fullStr | Comparison of vaccination strategies for the control of dog rabies in Machakos District, Kenya |
| title_full_unstemmed | Comparison of vaccination strategies for the control of dog rabies in Machakos District, Kenya |
| title_short | Comparison of vaccination strategies for the control of dog rabies in Machakos District, Kenya |
| title_sort | comparison of vaccination strategies for the control of dog rabies in machakos district kenya |
| topic | vaccination disease control |
| url | https://hdl.handle.net/10568/35329 |
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