Controlling malaria and African trypanosomiasis: The role of the mouse
Malaria and trypanosomiasis are vector-borne protozoal diseases which disproportionately affect the poor. Both give rise to immense human suffering; malaria exerts its effect directly on human health, while trypanosomiasis causes damage largely though its effect on the health and productivity of the...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Oxford University Press
2005
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/35256 |
| _version_ | 1855519049529688064 |
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| author | Foote, S.J. Iraqi, F.A. Kemp, Stephen J. |
| author_browse | Foote, S.J. Iraqi, F.A. Kemp, Stephen J. |
| author_facet | Foote, S.J. Iraqi, F.A. Kemp, Stephen J. |
| author_sort | Foote, S.J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Malaria and trypanosomiasis are vector-borne protozoal diseases which disproportionately affect the poor. Both give rise to immense human suffering; malaria exerts its effect directly on human health, while trypanosomiasis causes damage largely though its effect on the health and productivity of the livestock on which so many poor people depend. These diseases both have multifaceted and poorly understood mechanisms of pathogenesis, combined with relatively complex life cycles characterised by multiple stages in both insect vector and mammalian host. In both cases, there is a dramatic effect of host genotype on disease progression. This effect is apparent in both the human and cattle hosts and among inbred mouse strains. This provides an opportunity to use the mouse to probe the mechanisms underlying resistance or susceptibility to pathology. The availability of high-density linkage maps, the genome sequence and transcriptomics tools has transformed the power of the mouse to illuminate such fundamental aspects of the host-parasite interaction. |
| format | Journal Article |
| id | CGSpace35256 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2005 |
| publishDateRange | 2005 |
| publishDateSort | 2005 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| record_format | dspace |
| spelling | CGSpace352562024-08-27T10:35:15Z Controlling malaria and African trypanosomiasis: The role of the mouse Foote, S.J. Iraqi, F.A. Kemp, Stephen J. animal diseases research genetics molecular biology biochemistry Malaria and trypanosomiasis are vector-borne protozoal diseases which disproportionately affect the poor. Both give rise to immense human suffering; malaria exerts its effect directly on human health, while trypanosomiasis causes damage largely though its effect on the health and productivity of the livestock on which so many poor people depend. These diseases both have multifaceted and poorly understood mechanisms of pathogenesis, combined with relatively complex life cycles characterised by multiple stages in both insect vector and mammalian host. In both cases, there is a dramatic effect of host genotype on disease progression. This effect is apparent in both the human and cattle hosts and among inbred mouse strains. This provides an opportunity to use the mouse to probe the mechanisms underlying resistance or susceptibility to pathology. The availability of high-density linkage maps, the genome sequence and transcriptomics tools has transformed the power of the mouse to illuminate such fundamental aspects of the host-parasite interaction. 2005-01-01 2014-04-14T10:55:40Z 2014-04-14T10:55:40Z Journal Article https://hdl.handle.net/10568/35256 en Open Access Oxford University Press Foote, S.J., Iraqi, F. and Kemp, S.J. 2005. Controlling malaria and African trypanosomiasis: The role of the mouse. Briefings in Functional Genomics and Proteomics 4(3): 214 - 224 |
| spellingShingle | animal diseases research genetics molecular biology biochemistry Foote, S.J. Iraqi, F.A. Kemp, Stephen J. Controlling malaria and African trypanosomiasis: The role of the mouse |
| title | Controlling malaria and African trypanosomiasis: The role of the mouse |
| title_full | Controlling malaria and African trypanosomiasis: The role of the mouse |
| title_fullStr | Controlling malaria and African trypanosomiasis: The role of the mouse |
| title_full_unstemmed | Controlling malaria and African trypanosomiasis: The role of the mouse |
| title_short | Controlling malaria and African trypanosomiasis: The role of the mouse |
| title_sort | controlling malaria and african trypanosomiasis the role of the mouse |
| topic | animal diseases research genetics molecular biology biochemistry |
| url | https://hdl.handle.net/10568/35256 |
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