A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice
African trypanosomes are protozoan parasites that cause “sleeping sickness” in humans and a similar disease in livestock. Trypanosomes also infect laboratory mice and three major quantitative trait loci (QTL) that regulate survival time after infection with T. congolense have been identified in two...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Public Library of Science
2010
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/3500 |
| _version_ | 1855515265076297728 |
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| author | Goodhead, I. Archibald, A.L. Amwayi, P. Brass, A. Gibson, John P. Hall, N. Hughes, Monica A. Limo, M.K.H. Iraqi, F.A. Kemp, Stephen J. Noyes, H.A. |
| author_browse | Amwayi, P. Archibald, A.L. Brass, A. Gibson, John P. Goodhead, I. Hall, N. Hughes, Monica A. Iraqi, F.A. Kemp, Stephen J. Limo, M.K.H. Noyes, H.A. |
| author_facet | Goodhead, I. Archibald, A.L. Amwayi, P. Brass, A. Gibson, John P. Hall, N. Hughes, Monica A. Limo, M.K.H. Iraqi, F.A. Kemp, Stephen J. Noyes, H.A. |
| author_sort | Goodhead, I. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | African trypanosomes are protozoan parasites that cause “sleeping sickness” in humans and a similar disease in livestock. Trypanosomes also infect laboratory mice and three major quantitative trait loci (QTL) that regulate survival time after infection with T. congolense have been identified in two independent crosses between susceptible A/J and BALB/c mice, and the resistant C57BL/6. These were designated Tir1, Tir2 and Tir3 for Trypanosoma infection response, and range in size from 0.9–12 cM. |
| format | Journal Article |
| id | CGSpace3500 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2010 |
| publishDateRange | 2010 |
| publishDateSort | 2010 |
| publisher | Public Library of Science |
| publisherStr | Public Library of Science |
| record_format | dspace |
| spelling | CGSpace35002023-12-08T19:36:04Z A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice Goodhead, I. Archibald, A.L. Amwayi, P. Brass, A. Gibson, John P. Hall, N. Hughes, Monica A. Limo, M.K.H. Iraqi, F.A. Kemp, Stephen J. Noyes, H.A. trypanosomiasis infectious diseases African trypanosomes are protozoan parasites that cause “sleeping sickness” in humans and a similar disease in livestock. Trypanosomes also infect laboratory mice and three major quantitative trait loci (QTL) that regulate survival time after infection with T. congolense have been identified in two independent crosses between susceptible A/J and BALB/c mice, and the resistant C57BL/6. These were designated Tir1, Tir2 and Tir3 for Trypanosoma infection response, and range in size from 0.9–12 cM. 2010-11-09 2011-04-17T11:33:58Z 2011-04-17T11:33:58Z Journal Article https://hdl.handle.net/10568/3500 en Open Access Public Library of Science Goodhead, I., Archibald, A., Amwayi, P., Brass, A., Gibson, J., Hall, N., Hughes, M.A., Limo, M., Iraqi, F., Kemp, S.J. and Noyes, H.A. 2010. A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice. PLoS Neglected Tropical Diseases 4(11):e880. |
| spellingShingle | trypanosomiasis infectious diseases Goodhead, I. Archibald, A.L. Amwayi, P. Brass, A. Gibson, John P. Hall, N. Hughes, Monica A. Limo, M.K.H. Iraqi, F.A. Kemp, Stephen J. Noyes, H.A. A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice |
| title | A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice |
| title_full | A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice |
| title_fullStr | A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice |
| title_full_unstemmed | A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice |
| title_short | A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice |
| title_sort | comprehensive genetic analysis of candidate genes regulating response to trypanosoma congolense infection in mice |
| topic | trypanosomiasis infectious diseases |
| url | https://hdl.handle.net/10568/3500 |
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