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Endogenous retrovirus EAV-HP linked to blue egg phenotype in Mapuche fowl

Oocyan or blue/green eggshell colour is an autosomal dominant trait found in native chickens (Mapuche fowl) of Chile and in some of their descendants in European and North American modern breeds. We report here the identification of an endogenous avian retroviral (EAV-HP) insertion in oocyan Mapuche...

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Main Authors: Wragg, D., Mwacharo, Joram M., Alcalde, J.A., Wang, C., Han Jianlin, Gongora, J., Gourichon, D., Tixier-Boichard, M., Hanotte, Olivier H.
Format: Journal Article
Language:Inglés
Published: Public Library of Science 2013
Subjects:
animal diseases
poultry
Online Access:https://hdl.handle.net/10568/33909
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author Wragg, D.
Mwacharo, Joram M.
Alcalde, J.A.
Wang, C.
Han Jianlin
Gongora, J.
Gourichon, D.
Tixier-Boichard, M.
Hanotte, Olivier H.
author_browse Alcalde, J.A.
Gongora, J.
Gourichon, D.
Han Jianlin
Hanotte, Olivier H.
Mwacharo, Joram M.
Tixier-Boichard, M.
Wang, C.
Wragg, D.
author_facet Wragg, D.
Mwacharo, Joram M.
Alcalde, J.A.
Wang, C.
Han Jianlin
Gongora, J.
Gourichon, D.
Tixier-Boichard, M.
Hanotte, Olivier H.
author_sort Wragg, D.
collection Repository of Agricultural Research Outputs (CGSpace)
description Oocyan or blue/green eggshell colour is an autosomal dominant trait found in native chickens (Mapuche fowl) of Chile and in some of their descendants in European and North American modern breeds. We report here the identification of an endogenous avian retroviral (EAV-HP) insertion in oocyan Mapuche fowl and European breeds. Sequencing data reveals 100% retroviral identity between the Mapuche and European insertions. Quantitative real-time PCR analysis of European oocyan chicken indicates over-expression of the SLCO1B3 gene (P<0.05) in the shell gland and oviduct. Predicted transcription factor binding sites in the long terminal repeats (LTR) indicate AhR/Ar, a modulator of oestrogen, as a possible promoter/enhancer leading to reproductive tissue-specific over-expression of the SLCO1B3 gene. Analysis of all jungle fowl species Gallus sp. supports the retroviral insertion to be a post-domestication event, while identical LTR sequences within domestic chickens are in agreement with a recent de novo mutation.
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id CGSpace33909
institution CGIAR Consortium
language Inglés
publishDate 2013
publishDateRange 2013
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publisher Public Library of Science
publisherStr Public Library of Science
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spelling CGSpace339092024-01-09T09:50:16Z Endogenous retrovirus EAV-HP linked to blue egg phenotype in Mapuche fowl Wragg, D. Mwacharo, Joram M. Alcalde, J.A. Wang, C. Han Jianlin Gongora, J. Gourichon, D. Tixier-Boichard, M. Hanotte, Olivier H. animal diseases poultry Oocyan or blue/green eggshell colour is an autosomal dominant trait found in native chickens (Mapuche fowl) of Chile and in some of their descendants in European and North American modern breeds. We report here the identification of an endogenous avian retroviral (EAV-HP) insertion in oocyan Mapuche fowl and European breeds. Sequencing data reveals 100% retroviral identity between the Mapuche and European insertions. Quantitative real-time PCR analysis of European oocyan chicken indicates over-expression of the SLCO1B3 gene (P<0.05) in the shell gland and oviduct. Predicted transcription factor binding sites in the long terminal repeats (LTR) indicate AhR/Ar, a modulator of oestrogen, as a possible promoter/enhancer leading to reproductive tissue-specific over-expression of the SLCO1B3 gene. Analysis of all jungle fowl species Gallus sp. supports the retroviral insertion to be a post-domestication event, while identical LTR sequences within domestic chickens are in agreement with a recent de novo mutation. 2013-08-19 2013-11-03T14:07:33Z 2013-11-03T14:07:33Z Journal Article https://hdl.handle.net/10568/33909 en Open Access Public Library of Science Wragg, D., Mwacharo, J.M., Alcalde, J.A., Wang, C., Han Jianlin, Gongora, J., Gourichon, D., Tixier-Boichard, M. and Hanotte, O. 2013. Endogenous retrovirus EAV-HP linked to blue egg phenotype in Mapuche fowl. PLoS ONE 8(8): e71393.
spellingShingle animal diseases
poultry
Wragg, D.
Mwacharo, Joram M.
Alcalde, J.A.
Wang, C.
Han Jianlin
Gongora, J.
Gourichon, D.
Tixier-Boichard, M.
Hanotte, Olivier H.
Endogenous retrovirus EAV-HP linked to blue egg phenotype in Mapuche fowl
title Endogenous retrovirus EAV-HP linked to blue egg phenotype in Mapuche fowl
title_full Endogenous retrovirus EAV-HP linked to blue egg phenotype in Mapuche fowl
title_fullStr Endogenous retrovirus EAV-HP linked to blue egg phenotype in Mapuche fowl
title_full_unstemmed Endogenous retrovirus EAV-HP linked to blue egg phenotype in Mapuche fowl
title_short Endogenous retrovirus EAV-HP linked to blue egg phenotype in Mapuche fowl
title_sort endogenous retrovirus eav hp linked to blue egg phenotype in mapuche fowl
topic animal diseases
poultry
url https://hdl.handle.net/10568/33909
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AT mwacharojoramm endogenousretroviruseavhplinkedtoblueeggphenotypeinmapuchefowl
AT alcaldeja endogenousretroviruseavhplinkedtoblueeggphenotypeinmapuchefowl
AT wangc endogenousretroviruseavhplinkedtoblueeggphenotypeinmapuchefowl
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AT tixierboichardm endogenousretroviruseavhplinkedtoblueeggphenotypeinmapuchefowl
AT hanotteolivierh endogenousretroviruseavhplinkedtoblueeggphenotypeinmapuchefowl

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