Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva
Enhancement of the induction of cytotoxic T-cell responses by immunostimulatory CpG oligodeoxynucleotides has been described in humans and mouse models. The present study attempted to address whether CpG has a similar effect in cattle. Immunisation of cattle with a recombinant form of the polymorphi...
| Autores principales: | , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2007
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/33218 |
| _version_ | 1855539149474365440 |
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| author | Graham, S.P. Saya, R. Awino, Elias Ngugi, D. Nyanjui, J.K. Hecker, R. Taracha, E.L.N. Nene, Vishvanath M. |
| author_browse | Awino, Elias Graham, S.P. Hecker, R. Nene, Vishvanath M. Ngugi, D. Nyanjui, J.K. Saya, R. Taracha, E.L.N. |
| author_facet | Graham, S.P. Saya, R. Awino, Elias Ngugi, D. Nyanjui, J.K. Hecker, R. Taracha, E.L.N. Nene, Vishvanath M. |
| author_sort | Graham, S.P. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Enhancement of the induction of cytotoxic T-cell responses by immunostimulatory CpG oligodeoxynucleotides has been described in humans and mouse models. The present study attempted to address whether CpG has a similar effect in cattle. Immunisation of cattle with a recombinant form of the polymorphic immunodominant molecule from Theileria parva emulsified with immunostimulatory CpG oligodeoxynucleotides in adjuvant had no effect on the induction of antibody responses including the isotype profile, but significantly enhanced the induction of cytolytic responses that were mediated by CD4+CD3+ T cells utilizing the perforin-granzyme pathway. |
| format | Journal Article |
| id | CGSpace33218 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2007 |
| publishDateRange | 2007 |
| publishDateSort | 2007 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace332182024-05-01T08:19:33Z Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva Graham, S.P. Saya, R. Awino, Elias Ngugi, D. Nyanjui, J.K. Hecker, R. Taracha, E.L.N. Nene, Vishvanath M. theileria parva cattle vaccination toxicity lymphocytes immunostimulants immunology antigens Enhancement of the induction of cytotoxic T-cell responses by immunostimulatory CpG oligodeoxynucleotides has been described in humans and mouse models. The present study attempted to address whether CpG has a similar effect in cattle. Immunisation of cattle with a recombinant form of the polymorphic immunodominant molecule from Theileria parva emulsified with immunostimulatory CpG oligodeoxynucleotides in adjuvant had no effect on the induction of antibody responses including the isotype profile, but significantly enhanced the induction of cytolytic responses that were mediated by CD4+CD3+ T cells utilizing the perforin-granzyme pathway. 2007-02 2013-07-03T05:26:14Z 2013-07-03T05:26:14Z Journal Article https://hdl.handle.net/10568/33218 en Limited Access Elsevier Veterinary Immunology and Immunopathology;115(3-4): 383-389 |
| spellingShingle | theileria parva cattle vaccination toxicity lymphocytes immunostimulants immunology antigens Graham, S.P. Saya, R. Awino, Elias Ngugi, D. Nyanjui, J.K. Hecker, R. Taracha, E.L.N. Nene, Vishvanath M. Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva |
| title | Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva |
| title_full | Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva |
| title_fullStr | Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva |
| title_full_unstemmed | Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva |
| title_short | Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva |
| title_sort | immunostimulatory cpg oligodeoxynucleotides enhance the induction of bovine cd4 cytotoxic t lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite theileria parva |
| topic | theileria parva cattle vaccination toxicity lymphocytes immunostimulants immunology antigens |
| url | https://hdl.handle.net/10568/33218 |
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