Gene-knockout mice in malaria research: Useful or misleading?
Gene-knockout mice have been extensively used in the study of several malaria-induced pathologies. Some investigators believe that the deficient, infected mice mimic disease aspects produced in the absence of the target gene, but others believe that the deficient mice models mainly explain the effec...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Elsevier
2007
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/33188 |
| _version_ | 1855527229186899968 |
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| author | Hernández Valladares, M. Naessens, Jan Iraqi, F.A. |
| author_browse | Hernández Valladares, M. Iraqi, F.A. Naessens, Jan |
| author_facet | Hernández Valladares, M. Naessens, Jan Iraqi, F.A. |
| author_sort | Hernández Valladares, M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Gene-knockout mice have been extensively used in the study of several malaria-induced pathologies. Some investigators believe that the deficient, infected mice mimic disease aspects produced in the absence of the target gene, but others believe that the deficient mice models mainly explain the effects of compensatory, related molecules. Comparison of some of the most relevant knockout mouse studies for understanding cerebral malaria and parasitemia and their related human reports shows that gene-knockout mice are useful tools that support conclusions from human genetic studies. These mice have helped to indicate new resistance genes against human malaria and have provided valuable information about mechanisms of malaria resistance in mice. |
| format | Journal Article |
| id | CGSpace33188 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2007 |
| publishDateRange | 2007 |
| publishDateSort | 2007 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace331882023-12-08T19:36:04Z Gene-knockout mice in malaria research: Useful or misleading? Hernández Valladares, M. Naessens, Jan Iraqi, F.A. genetic resistance mice disease resistance malaria research brain parasites human diseases pathology Gene-knockout mice have been extensively used in the study of several malaria-induced pathologies. Some investigators believe that the deficient, infected mice mimic disease aspects produced in the absence of the target gene, but others believe that the deficient mice models mainly explain the effects of compensatory, related molecules. Comparison of some of the most relevant knockout mouse studies for understanding cerebral malaria and parasitemia and their related human reports shows that gene-knockout mice are useful tools that support conclusions from human genetic studies. These mice have helped to indicate new resistance genes against human malaria and have provided valuable information about mechanisms of malaria resistance in mice. 2007-11 2013-07-03T05:26:12Z 2013-07-03T05:26:12Z Journal Article https://hdl.handle.net/10568/33188 en Limited Access Elsevier Trends In Parasitology;23(11): 522-526 |
| spellingShingle | genetic resistance mice disease resistance malaria research brain parasites human diseases pathology Hernández Valladares, M. Naessens, Jan Iraqi, F.A. Gene-knockout mice in malaria research: Useful or misleading? |
| title | Gene-knockout mice in malaria research: Useful or misleading? |
| title_full | Gene-knockout mice in malaria research: Useful or misleading? |
| title_fullStr | Gene-knockout mice in malaria research: Useful or misleading? |
| title_full_unstemmed | Gene-knockout mice in malaria research: Useful or misleading? |
| title_short | Gene-knockout mice in malaria research: Useful or misleading? |
| title_sort | gene knockout mice in malaria research useful or misleading |
| topic | genetic resistance mice disease resistance malaria research brain parasites human diseases pathology |
| url | https://hdl.handle.net/10568/33188 |
| work_keys_str_mv | AT hernandezvalladaresm geneknockoutmiceinmalariaresearchusefulormisleading AT naessensjan geneknockoutmiceinmalariaresearchusefulormisleading AT iraqifa geneknockoutmiceinmalariaresearchusefulormisleading |