Genetic resistance to malaria in mouse models
Murine models have proved to be excellent tools in the support of studies of the human genetic bases of malaria resistance and have enabled the mapping of 12 resistance loci, eight of them controlling parasitic levels and four controlling cerebral malaria. Further studies using this method have iden...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Elsevier
2005
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/33187 |
| _version_ | 1855527599796649984 |
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| author | Hernández Valladares, M. Naessens, Jan Iraqi, F.A. |
| author_browse | Hernández Valladares, M. Iraqi, F.A. Naessens, Jan |
| author_facet | Hernández Valladares, M. Naessens, Jan Iraqi, F.A. |
| author_sort | Hernández Valladares, M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Murine models have proved to be excellent tools in the support of studies of the human genetic bases of malaria resistance and have enabled the mapping of 12 resistance loci, eight of them controlling parasitic levels and four controlling cerebral malaria. Further studies using this method have identified a Pklr variant that confers resistance to murine malaria, a result that shows the potential of this approach to aid the understanding of mechanisms of disease resistance. In the future, the use of murine models for genetic resistance to malaria could lead to the identification of relevant genetic factors that control this devastating disease. |
| format | Journal Article |
| id | CGSpace33187 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2005 |
| publishDateRange | 2005 |
| publishDateSort | 2005 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace331872023-12-08T19:36:04Z Genetic resistance to malaria in mouse models Hernández Valladares, M. Naessens, Jan Iraqi, F.A. genetic resistance mice models brain disease resistance malaria Murine models have proved to be excellent tools in the support of studies of the human genetic bases of malaria resistance and have enabled the mapping of 12 resistance loci, eight of them controlling parasitic levels and four controlling cerebral malaria. Further studies using this method have identified a Pklr variant that confers resistance to murine malaria, a result that shows the potential of this approach to aid the understanding of mechanisms of disease resistance. In the future, the use of murine models for genetic resistance to malaria could lead to the identification of relevant genetic factors that control this devastating disease. 2005-08 2013-07-03T05:26:12Z 2013-07-03T05:26:12Z Journal Article https://hdl.handle.net/10568/33187 en Limited Access Elsevier Trends In Parasitology;21(8): 352-355 |
| spellingShingle | genetic resistance mice models brain disease resistance malaria Hernández Valladares, M. Naessens, Jan Iraqi, F.A. Genetic resistance to malaria in mouse models |
| title | Genetic resistance to malaria in mouse models |
| title_full | Genetic resistance to malaria in mouse models |
| title_fullStr | Genetic resistance to malaria in mouse models |
| title_full_unstemmed | Genetic resistance to malaria in mouse models |
| title_short | Genetic resistance to malaria in mouse models |
| title_sort | genetic resistance to malaria in mouse models |
| topic | genetic resistance mice models brain disease resistance malaria |
| url | https://hdl.handle.net/10568/33187 |
| work_keys_str_mv | AT hernandezvalladaresm geneticresistancetomalariainmousemodels AT naessensjan geneticresistancetomalariainmousemodels AT iraqifa geneticresistancetomalariainmousemodels |