Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies
Theileria parva is an intracellular sporozoan parasite that infects and transforms bovine lymphocytes, causing a severe lymphoproliferative disease known as East Coast fever in eastern, central and southern Africa. In this article, Declan McKeever and colleagues summarize the current understanding o...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Elsevier
1999
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/33104 |
| _version_ | 1855514129391943680 |
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| author | McKeever, Declan J. Taracha, E.L.N. Morrison, W. Ivan Musoke, A.J. Morzaria, S.P. |
| author_browse | McKeever, Declan J. Morrison, W. Ivan Morzaria, S.P. Musoke, A.J. Taracha, E.L.N. |
| author_facet | McKeever, Declan J. Taracha, E.L.N. Morrison, W. Ivan Musoke, A.J. Morzaria, S.P. |
| author_sort | McKeever, Declan J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Theileria parva is an intracellular sporozoan parasite that infects and transforms bovine lymphocytes, causing a severe lymphoproliferative disease known as East Coast fever in eastern, central and southern Africa. In this article, Declan McKeever and colleagues summarize the current understanding of immune mechanisms provoked by the parasite with regard to their role in both pathogenesis and protection. In particular, the influence of genomic polymorphism in parasite and host on the development of immunity is discussed, along with the evolution of current vaccine development strategies as a result of immunological research on the disease. |
| format | Journal Article |
| id | CGSpace33104 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1999 |
| publishDateRange | 1999 |
| publishDateSort | 1999 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace331042024-04-25T06:00:15Z Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies McKeever, Declan J. Taracha, E.L.N. Morrison, W. Ivan Musoke, A.J. Morzaria, S.P. theileria parva vaccines tickborne diseases immune response east coast fever immunological diseases parasitology Theileria parva is an intracellular sporozoan parasite that infects and transforms bovine lymphocytes, causing a severe lymphoproliferative disease known as East Coast fever in eastern, central and southern Africa. In this article, Declan McKeever and colleagues summarize the current understanding of immune mechanisms provoked by the parasite with regard to their role in both pathogenesis and protection. In particular, the influence of genomic polymorphism in parasite and host on the development of immunity is discussed, along with the evolution of current vaccine development strategies as a result of immunological research on the disease. 1999-07 2013-07-03T05:26:04Z 2013-07-03T05:26:04Z Journal Article https://hdl.handle.net/10568/33104 en Limited Access Elsevier Parasitology Today;15(7): 263-267 |
| spellingShingle | theileria parva vaccines tickborne diseases immune response east coast fever immunological diseases parasitology McKeever, Declan J. Taracha, E.L.N. Morrison, W. Ivan Musoke, A.J. Morzaria, S.P. Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies |
| title | Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies |
| title_full | Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies |
| title_fullStr | Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies |
| title_full_unstemmed | Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies |
| title_short | Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies |
| title_sort | protective immune mechanisms against theileria parva evolution of vaccine development strategies |
| topic | theileria parva vaccines tickborne diseases immune response east coast fever immunological diseases parasitology |
| url | https://hdl.handle.net/10568/33104 |
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