Local skin reaction (chancre) induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on CD4 T lymphocytes
The first visible response in livestock to the bite of a trypanosome-infected tsetse fly is the formation of a localized skin reaction, also known as a chancre. This is an inflammatory response in the skin associated with swelling and an influx of cells. It is thought to be associated with an acquir...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Wiley
2003
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/33088 |
| _version_ | 1855515342747467776 |
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| author | Naessens, Jan Mwangi, David Miano Buza, J. Moloo, S.K. |
| author_browse | Buza, J. Moloo, S.K. Mwangi, David Miano Naessens, Jan |
| author_facet | Naessens, Jan Mwangi, David Miano Buza, J. Moloo, S.K. |
| author_sort | Naessens, Jan |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The first visible response in livestock to the bite of a trypanosome-infected tsetse fly is the formation of a localized skin reaction, also known as a chancre. This is an inflammatory response in the skin associated with swelling and an influx of cells. It is thought to be associated with an acquired immune response to the injected metacyclic trypanosomes. In this study, we examined the role of T lymphocytes in the development of the inflammatory response, by depleting cattle of T cell subpopulations and monitoring the development of chancres. Depletion of CD4 cells, but not CD8 cells, resulted in a significant reduction in chancre formation, confirming that an acquired response mediates the inflammatory response. In addition, it was established that the CD4 T cells mediate the generation of memory for immunity to a homologueous re-challenge. The inflammatory response in the skin did not affect further progress of the infection. [Journal Article; In English; England] |
| format | Journal Article |
| id | CGSpace33088 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2003 |
| publishDateRange | 2003 |
| publishDateSort | 2003 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace330882024-03-06T10:16:43Z Local skin reaction (chancre) induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on CD4 T lymphocytes Naessens, Jan Mwangi, David Miano Buza, J. Moloo, S.K. cattle phytomonas skin diseases inoculation glossinidae lymphocytes immunology trypanosoma congolense trypanosomiasis parasitology The first visible response in livestock to the bite of a trypanosome-infected tsetse fly is the formation of a localized skin reaction, also known as a chancre. This is an inflammatory response in the skin associated with swelling and an influx of cells. It is thought to be associated with an acquired immune response to the injected metacyclic trypanosomes. In this study, we examined the role of T lymphocytes in the development of the inflammatory response, by depleting cattle of T cell subpopulations and monitoring the development of chancres. Depletion of CD4 cells, but not CD8 cells, resulted in a significant reduction in chancre formation, confirming that an acquired response mediates the inflammatory response. In addition, it was established that the CD4 T cells mediate the generation of memory for immunity to a homologueous re-challenge. The inflammatory response in the skin did not affect further progress of the infection. [Journal Article; In English; England] 2003-08 2013-07-03T05:26:02Z 2013-07-03T05:26:02Z Journal Article https://hdl.handle.net/10568/33088 en Limited Access Wiley Parasite Immunology;25(8-9): 413-419 |
| spellingShingle | cattle phytomonas skin diseases inoculation glossinidae lymphocytes immunology trypanosoma congolense trypanosomiasis parasitology Naessens, Jan Mwangi, David Miano Buza, J. Moloo, S.K. Local skin reaction (chancre) induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on CD4 T lymphocytes |
| title | Local skin reaction (chancre) induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on CD4 T lymphocytes |
| title_full | Local skin reaction (chancre) induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on CD4 T lymphocytes |
| title_fullStr | Local skin reaction (chancre) induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on CD4 T lymphocytes |
| title_full_unstemmed | Local skin reaction (chancre) induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on CD4 T lymphocytes |
| title_short | Local skin reaction (chancre) induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on CD4 T lymphocytes |
| title_sort | local skin reaction chancre induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on cd4 t lymphocytes |
| topic | cattle phytomonas skin diseases inoculation glossinidae lymphocytes immunology trypanosoma congolense trypanosomiasis parasitology |
| url | https://hdl.handle.net/10568/33088 |
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