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Molecular characterisation of a Theileria lestoquardi gene encoding a candidate sporozoite vaccine antigen

Theileria are tick-transmitted, haemoprotozoan parasites infecting wild and domestic ungulates throughout many areas of the world. The most economically important species are T. parva and T. annulata which are pathogenic to cattle, and T. lestoquardi (syn hirci) which is pathogenic to sheep and goat...

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Main Authors: Skilton, Robert A., Musoke, A.J., Nene, Vishvanath M., Wasawo, D.P.S., Wells, C.W., Spooner, P.R., Bishop, Richard P., Osaso, J., Nkonge, C., Latif, A., Morzaria, S.P.
Format: Journal Article
Language:Inglés
Published: Elsevier 2000
Subjects:
theileria lestoquardi
vaccines
sporozoa
antigens
antibodies
molecular biology
parasitology
Online Access:https://hdl.handle.net/10568/33064
Summary:Theileria are tick-transmitted, haemoprotozoan parasites infecting wild and domestic ungulates throughout many areas of the world. The most economically important species are T. parva and T. annulata which are pathogenic to cattle, and T. lestoquardi (syn hirci) which is pathogenic to sheep and goats. This report describes the cloning and analysis of the gene encoding the p67/SPAG-1 homologue of T. lestoquardi. This protein which is called SLAG-1 (sporozoite lestoquardi antigen 1), is predicted to have potential as a sporozoite - neutralisation antigen for inclusion in a sub-unit vaccine against T. lestoquardi infection of sheep and goats.

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