Organisation and informational content of the Theileria parva genome
When compared with other Apicomplexan organisms. Theileria parva has an execptionally small, 10-12 Mbp. genome. There are only 4 chromosomes, each in the Mbp range, and a complete physical map, based on SfiI linking data, is available for each one. A number of genes and cDNAs have been mapped to spe...
| Main Authors: | , , |
|---|---|
| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Elsevier
1998
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/33061 |
| _version_ | 1855530022556663808 |
|---|---|
| author | Nene, Vishvanath M. Morzaria, S.P. Bishop, Richard P. |
| author_browse | Bishop, Richard P. Morzaria, S.P. Nene, Vishvanath M. |
| author_facet | Nene, Vishvanath M. Morzaria, S.P. Bishop, Richard P. |
| author_sort | Nene, Vishvanath M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | When compared with other Apicomplexan organisms. Theileria parva has an execptionally small, 10-12 Mbp. genome. There are only 4 chromosomes, each in the Mbp range, and a complete physical map, based on SfiI linking data, is available for each one. A number of genes and cDNAs have been mapped to specific SfiI fragments. Telomeres consist of the simple repeat sequence typical of chromosomal ends but sub-telomeric homologies do not extend beyond 5 kbp. The only dispersed repetitive sequences identified to data are minisatellites, but these are found on a subset of SfiI fragments. There are clusters of distinct multicopy sequences which contain ORFs. However, the majority of parasite protein coding genes are present in a single copy. They have a compact structure, exhibit a bias in codon usage and non-translated regions are small. Introns, if present, are unusually short. Overall, the genome contains remarkably little repetitive, non-coding DNA. The parasite mitochondrial DNA is linear in structure, has a limited protein coding capacity and fragmented rRNA genes and its telomeres contain inverted repeat sequences. |
| format | Journal Article |
| id | CGSpace33061 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1998 |
| publishDateRange | 1998 |
| publishDateSort | 1998 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace330612024-05-01T08:18:07Z Organisation and informational content of the Theileria parva genome Nene, Vishvanath M. Morzaria, S.P. Bishop, Richard P. theileria parva genomes east coast fever neoplasms sporozoa chromosomes dna genetic polymorphism When compared with other Apicomplexan organisms. Theileria parva has an execptionally small, 10-12 Mbp. genome. There are only 4 chromosomes, each in the Mbp range, and a complete physical map, based on SfiI linking data, is available for each one. A number of genes and cDNAs have been mapped to specific SfiI fragments. Telomeres consist of the simple repeat sequence typical of chromosomal ends but sub-telomeric homologies do not extend beyond 5 kbp. The only dispersed repetitive sequences identified to data are minisatellites, but these are found on a subset of SfiI fragments. There are clusters of distinct multicopy sequences which contain ORFs. However, the majority of parasite protein coding genes are present in a single copy. They have a compact structure, exhibit a bias in codon usage and non-translated regions are small. Introns, if present, are unusually short. Overall, the genome contains remarkably little repetitive, non-coding DNA. The parasite mitochondrial DNA is linear in structure, has a limited protein coding capacity and fragmented rRNA genes and its telomeres contain inverted repeat sequences. 1998-09-01 2013-07-03T05:26:00Z 2013-07-03T05:26:00Z Journal Article https://hdl.handle.net/10568/33061 en Limited Access Elsevier Molecular and Biochemical Parasitology;95: 1-8 |
| spellingShingle | theileria parva genomes east coast fever neoplasms sporozoa chromosomes dna genetic polymorphism Nene, Vishvanath M. Morzaria, S.P. Bishop, Richard P. Organisation and informational content of the Theileria parva genome |
| title | Organisation and informational content of the Theileria parva genome |
| title_full | Organisation and informational content of the Theileria parva genome |
| title_fullStr | Organisation and informational content of the Theileria parva genome |
| title_full_unstemmed | Organisation and informational content of the Theileria parva genome |
| title_short | Organisation and informational content of the Theileria parva genome |
| title_sort | organisation and informational content of the theileria parva genome |
| topic | theileria parva genomes east coast fever neoplasms sporozoa chromosomes dna genetic polymorphism |
| url | https://hdl.handle.net/10568/33061 |
| work_keys_str_mv | AT nenevishvanathm organisationandinformationalcontentofthetheileriaparvagenome AT morzariasp organisationandinformationalcontentofthetheileriaparvagenome AT bishoprichardp organisationandinformationalcontentofthetheileriaparvagenome |