Cytokine regulation by virus infection: Bovine viral diarrhea virus, a flavivirus, downregulates production of tumor necrosis factor alpha in macrophages in vitro
Bovine bone marrow-derived macrophages were infected in vitro with non-cytopathic or cytopathic strains of bovine viral diarrhoea virus. Infection with both biotypes resulted in a decreased production of tumour necrosis factor alpha upon stimulation with heat-inactivated Salmonella dublin or lipopol...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
1996
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/33023 |
| _version_ | 1855516974478524416 |
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| author | Adler, H. Jungi, T.W. Pfister, H. Strasser, M. Sileghem, M.R. Peterhans, E. |
| author_browse | Adler, H. Jungi, T.W. Peterhans, E. Pfister, H. Sileghem, M.R. Strasser, M. |
| author_facet | Adler, H. Jungi, T.W. Pfister, H. Strasser, M. Sileghem, M.R. Peterhans, E. |
| author_sort | Adler, H. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Bovine bone marrow-derived macrophages were infected in vitro with non-cytopathic or cytopathic strains of bovine viral diarrhoea virus. Infection with both biotypes resulted in a decreased production of tumour necrosis factor alpha upon stimulation with heat-inactivated Salmonella dublin or lipopolysaccharide. Other macrophage functions were not downregulated, indicating that the observed effect was not due to a loss in macrophage viability. The downregulated production of tumour necrosis factor alpha in infected macrophages may contribute to the well-documented immunosuppression in animals infected with bovine viral diarrhoea virus. |
| format | Journal Article |
| id | CGSpace33023 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1996 |
| publishDateRange | 1996 |
| publishDateSort | 1996 |
| record_format | dspace |
| spelling | CGSpace330232022-01-29T17:20:28Z Cytokine regulation by virus infection: Bovine viral diarrhea virus, a flavivirus, downregulates production of tumor necrosis factor alpha in macrophages in vitro Adler, H. Jungi, T.W. Pfister, H. Strasser, M. Sileghem, M.R. Peterhans, E. cytokines immunosuppression biological differences macrophages viroses bovine diarrhoea pestivirus viruses Bovine bone marrow-derived macrophages were infected in vitro with non-cytopathic or cytopathic strains of bovine viral diarrhoea virus. Infection with both biotypes resulted in a decreased production of tumour necrosis factor alpha upon stimulation with heat-inactivated Salmonella dublin or lipopolysaccharide. Other macrophage functions were not downregulated, indicating that the observed effect was not due to a loss in macrophage viability. The downregulated production of tumour necrosis factor alpha in infected macrophages may contribute to the well-documented immunosuppression in animals infected with bovine viral diarrhoea virus. 1996 2013-07-03T05:25:56Z 2013-07-03T05:25:56Z Journal Article https://hdl.handle.net/10568/33023 en Limited Access Journal of Virology;70(4): 2650-2653 |
| spellingShingle | cytokines immunosuppression biological differences macrophages viroses bovine diarrhoea pestivirus viruses Adler, H. Jungi, T.W. Pfister, H. Strasser, M. Sileghem, M.R. Peterhans, E. Cytokine regulation by virus infection: Bovine viral diarrhea virus, a flavivirus, downregulates production of tumor necrosis factor alpha in macrophages in vitro |
| title | Cytokine regulation by virus infection: Bovine viral diarrhea virus, a flavivirus, downregulates production of tumor necrosis factor alpha in macrophages in vitro |
| title_full | Cytokine regulation by virus infection: Bovine viral diarrhea virus, a flavivirus, downregulates production of tumor necrosis factor alpha in macrophages in vitro |
| title_fullStr | Cytokine regulation by virus infection: Bovine viral diarrhea virus, a flavivirus, downregulates production of tumor necrosis factor alpha in macrophages in vitro |
| title_full_unstemmed | Cytokine regulation by virus infection: Bovine viral diarrhea virus, a flavivirus, downregulates production of tumor necrosis factor alpha in macrophages in vitro |
| title_short | Cytokine regulation by virus infection: Bovine viral diarrhea virus, a flavivirus, downregulates production of tumor necrosis factor alpha in macrophages in vitro |
| title_sort | cytokine regulation by virus infection bovine viral diarrhea virus a flavivirus downregulates production of tumor necrosis factor alpha in macrophages in vitro |
| topic | cytokines immunosuppression biological differences macrophages viroses bovine diarrhoea pestivirus viruses |
| url | https://hdl.handle.net/10568/33023 |
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