Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: Targetting the disease rather than the parasite
In order to test the hypothesis that trypanosome cysteine proteinases (CPs) contribute to pathology of trypanosomosis. cattle were immunised with CPl and/or CP2, the major Cps of Trypanosoma congolense, and subsequently challenged with T. congolense. Immunisation had no effect on the establishment o...
| Autores principales: | , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2001
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/32952 |
| _version_ | 1855541168379527168 |
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| author | Authié, Edith Boulange, A.F. Muteti, D. Lalmanach, G. Gauthier, F. Musoke, A.J. |
| author_browse | Authié, Edith Boulange, A.F. Gauthier, F. Lalmanach, G. Musoke, A.J. Muteti, D. |
| author_facet | Authié, Edith Boulange, A.F. Muteti, D. Lalmanach, G. Gauthier, F. Musoke, A.J. |
| author_sort | Authié, Edith |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | In order to test the hypothesis that trypanosome cysteine proteinases (CPs) contribute to pathology of trypanosomosis. cattle were immunised with CPl and/or CP2, the major Cps of Trypanosoma congolense, and subsequently challenged with T. congolense. Immunisation had no effect on the establishment of infection and the development of acute anaemia. However, immunised cattle, unlike control cattle, maintained or gained weight during infection. Their haematocrit and leukocyte counts showed a tendency to recovery after 2-3 months of infection. Cattle immunised with CP2 mounted early and prominent IgG responses to CPs and to the variable surface glycoprotein following challenge. Thus trypanosome CPs may play a role in anaemia and immunosuppression; conversely, anti-CP antibody may modulate the trypanosome-induced pathology. |
| format | Journal Article |
| id | CGSpace32952 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2001 |
| publishDateRange | 2001 |
| publishDateSort | 2001 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace329522024-04-25T06:01:52Z Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: Targetting the disease rather than the parasite Authié, Edith Boulange, A.F. Muteti, D. Lalmanach, G. Gauthier, F. Musoke, A.J. cattle trypanosoma congolense immunisation cysteine peptidases In order to test the hypothesis that trypanosome cysteine proteinases (CPs) contribute to pathology of trypanosomosis. cattle were immunised with CPl and/or CP2, the major Cps of Trypanosoma congolense, and subsequently challenged with T. congolense. Immunisation had no effect on the establishment of infection and the development of acute anaemia. However, immunised cattle, unlike control cattle, maintained or gained weight during infection. Their haematocrit and leukocyte counts showed a tendency to recovery after 2-3 months of infection. Cattle immunised with CP2 mounted early and prominent IgG responses to CPs and to the variable surface glycoprotein following challenge. Thus trypanosome CPs may play a role in anaemia and immunosuppression; conversely, anti-CP antibody may modulate the trypanosome-induced pathology. 2001-11 2013-07-03T05:25:49Z 2013-07-03T05:25:49Z Journal Article https://hdl.handle.net/10568/32952 en Limited Access Elsevier International Journal for Parasitology;31(13): 1429-1433 |
| spellingShingle | cattle trypanosoma congolense immunisation cysteine peptidases Authié, Edith Boulange, A.F. Muteti, D. Lalmanach, G. Gauthier, F. Musoke, A.J. Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: Targetting the disease rather than the parasite |
| title | Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: Targetting the disease rather than the parasite |
| title_full | Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: Targetting the disease rather than the parasite |
| title_fullStr | Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: Targetting the disease rather than the parasite |
| title_full_unstemmed | Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: Targetting the disease rather than the parasite |
| title_short | Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: Targetting the disease rather than the parasite |
| title_sort | immunisation of cattle with cysteine proteinases of trypanosoma congolense targetting the disease rather than the parasite |
| topic | cattle trypanosoma congolense immunisation cysteine peptidases |
| url | https://hdl.handle.net/10568/32952 |
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