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Molecular characterization of bovine CD26 upregulated by a staphylococcal superantigen

In this report, we describe the cloning, sequencing, and expression of the bovine orthologue of CD26 (BoCD26). Several monoclonal antibodies specific for a molecule, activation molecule 3 (ACT3), aberrantly expressed on superantigen-stimulated bovine CD8+ lymphocytes, reacted with recombinant BoCD26...

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Main Authors: Sang-Un Lee, Young-Ho Park, Davis, W.C., Hamilton, M. Jo, Naessens, Jan, Bohach, G.A.
Format: Journal Article
Language:Inglés
Published: Springer 2002
Subjects:
bovidae
mankind
antigens
staphylococcus
Online Access:https://hdl.handle.net/10568/32945
Summary:In this report, we describe the cloning, sequencing, and expression of the bovine orthologue of CD26 (BoCD26). Several monoclonal antibodies specific for a molecule, activation molecule 3 (ACT3), aberrantly expressed on superantigen-stimulated bovine CD8+ lymphocytes, reacted with recombinant BoCD26 expressed in COS-7 and CHO cells. We also showed that human CD8+ T cells stimulated by a superantigen expressed CD26 at high levels. These results demonstrate that ACT3 is identical to BoCD26 and suggest that CD26 upregulation on CD8+ T cells is a general phenomenon of superantigens and not limited to their effects on bovine cells.

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