Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi
Susceptible A/J and more resistant C57BL/6J mice were infected with Plasmodium chabaudi chabaudi 54X, P.c. chabaudi AS and Plasmodium chabaudi adami 408XZ. As expected, most C57BL/6J mice survived the infections with the different isolates. But in contrast to previous observations, not all A/J mice...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Elsevier
2004
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/32918 |
| _version_ | 1855539741248716800 |
|---|---|
| author | Hernández Valladares, M. Naessens, Jan Nagda, S.M. Musoke, A.J. Rihet, P. Ole-MoiYoi, O.K. Iraqi, F.A. |
| author_browse | Hernández Valladares, M. Iraqi, F.A. Musoke, A.J. Naessens, Jan Nagda, S.M. Ole-MoiYoi, O.K. Rihet, P. |
| author_facet | Hernández Valladares, M. Naessens, Jan Nagda, S.M. Musoke, A.J. Rihet, P. Ole-MoiYoi, O.K. Iraqi, F.A. |
| author_sort | Hernández Valladares, M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Susceptible A/J and more resistant C57BL/6J mice were infected with Plasmodium chabaudi chabaudi 54X, P.c. chabaudi AS and Plasmodium chabaudi adami 408XZ. As expected, most C57BL/6J mice survived the infections with the different isolates. But in contrast to previous observations, not all A/J mice succumbed to infection: just over 50% of A/J mice survived infections with P.c. chabaudi 54X, while 80% survived P.c. chabaudi AS. The more virulent parasite, P.c. adami 408XZ, was able to kill all A/J mice and 20% of C57BL/6J mice after an intravenous infection with 105 pRBC. A detailed study of four parameters of pathology (body weight, body temperature, blood glucose and RBC counts) in both mouse strains after a P.c. adami 408XZ infection showed similar patterns to those previously reported after infection with P.c. chabaudi AS. These data suggest that environmental factors as well as parasite polymorphisms might influence the severity of malaria between susceptible and resistant mice. |
| format | Journal Article |
| id | CGSpace32918 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2004 |
| publishDateRange | 2004 |
| publishDateSort | 2004 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace329182024-05-01T08:19:36Z Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi Hernández Valladares, M. Naessens, Jan Nagda, S.M. Musoke, A.J. Rihet, P. Ole-MoiYoi, O.K. Iraqi, F.A. plasmodium pathology genetic resistance mice erythrocytes malaria Susceptible A/J and more resistant C57BL/6J mice were infected with Plasmodium chabaudi chabaudi 54X, P.c. chabaudi AS and Plasmodium chabaudi adami 408XZ. As expected, most C57BL/6J mice survived the infections with the different isolates. But in contrast to previous observations, not all A/J mice succumbed to infection: just over 50% of A/J mice survived infections with P.c. chabaudi 54X, while 80% survived P.c. chabaudi AS. The more virulent parasite, P.c. adami 408XZ, was able to kill all A/J mice and 20% of C57BL/6J mice after an intravenous infection with 105 pRBC. A detailed study of four parameters of pathology (body weight, body temperature, blood glucose and RBC counts) in both mouse strains after a P.c. adami 408XZ infection showed similar patterns to those previously reported after infection with P.c. chabaudi AS. These data suggest that environmental factors as well as parasite polymorphisms might influence the severity of malaria between susceptible and resistant mice. 2004-11 2013-07-03T05:25:45Z 2013-07-03T05:25:45Z Journal Article https://hdl.handle.net/10568/32918 en Limited Access Elsevier Experimental Parasitology;108(3-4): 134-141 |
| spellingShingle | plasmodium pathology genetic resistance mice erythrocytes malaria Hernández Valladares, M. Naessens, Jan Nagda, S.M. Musoke, A.J. Rihet, P. Ole-MoiYoi, O.K. Iraqi, F.A. Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi |
| title | Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi |
| title_full | Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi |
| title_fullStr | Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi |
| title_full_unstemmed | Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi |
| title_short | Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi |
| title_sort | comparison of pathology in susceptible a j and resistant c57bl 6j mice after infection with different sub strains of plasmodium chabaudi |
| topic | plasmodium pathology genetic resistance mice erythrocytes malaria |
| url | https://hdl.handle.net/10568/32918 |
| work_keys_str_mv | AT hernandezvalladaresm comparisonofpathologyinsusceptibleajandresistantc57bl6jmiceafterinfectionwithdifferentsubstrainsofplasmodiumchabaudi AT naessensjan comparisonofpathologyinsusceptibleajandresistantc57bl6jmiceafterinfectionwithdifferentsubstrainsofplasmodiumchabaudi AT nagdasm comparisonofpathologyinsusceptibleajandresistantc57bl6jmiceafterinfectionwithdifferentsubstrainsofplasmodiumchabaudi AT musokeaj comparisonofpathologyinsusceptibleajandresistantc57bl6jmiceafterinfectionwithdifferentsubstrainsofplasmodiumchabaudi AT rihetp comparisonofpathologyinsusceptibleajandresistantc57bl6jmiceafterinfectionwithdifferentsubstrainsofplasmodiumchabaudi AT olemoiyoiok comparisonofpathologyinsusceptibleajandresistantc57bl6jmiceafterinfectionwithdifferentsubstrainsofplasmodiumchabaudi AT iraqifa comparisonofpathologyinsusceptibleajandresistantc57bl6jmiceafterinfectionwithdifferentsubstrainsofplasmodiumchabaudi |