Cross-resistance associated with development resistance to isometamidium in a clone of Trypanosoma congolense
Resistance to isometamidium was increased 94-fold in a clone of Trypanosoma congolense (clone IL 1180) by repeated subcurative treatment of infected mice for 11 months. This was associated with 3.4-, 33-, and 4.2-fold increases in resistance to diminazene, homidium, and quinapyramine, respectively....
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
1997
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/30084 |
| _version_ | 1855540251692367872 |
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| author | Peregrine, A.S. Gray, M.A. Moloo, S.K. |
| author_browse | Gray, M.A. Moloo, S.K. Peregrine, A.S. |
| author_facet | Peregrine, A.S. Gray, M.A. Moloo, S.K. |
| author_sort | Peregrine, A.S. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Resistance to isometamidium was increased 94-fold in a clone of Trypanosoma congolense (clone IL 1180) by repeated subcurative treatment of infected mice for 11 months. This was associated with 3.4-, 33-, and 4.2-fold increases in resistance to diminazene, homidium, and quinapyramine, respectively. Both T. congolense IL 1180 and the resistant derivative were able to undergo cyclical development in Glossina morsitans centralis tsetse flies, producing hypopharyngeal infection rates of 40.0 and 39.8 percent, respectively. |
| format | Journal Article |
| id | CGSpace30084 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1997 |
| publishDateRange | 1997 |
| publishDateSort | 1997 |
| record_format | dspace |
| spelling | CGSpace300842022-01-29T16:17:57Z Cross-resistance associated with development resistance to isometamidium in a clone of Trypanosoma congolense Peregrine, A.S. Gray, M.A. Moloo, S.K. trypanosoma congolense drugs resistance to chemicals Resistance to isometamidium was increased 94-fold in a clone of Trypanosoma congolense (clone IL 1180) by repeated subcurative treatment of infected mice for 11 months. This was associated with 3.4-, 33-, and 4.2-fold increases in resistance to diminazene, homidium, and quinapyramine, respectively. Both T. congolense IL 1180 and the resistant derivative were able to undergo cyclical development in Glossina morsitans centralis tsetse flies, producing hypopharyngeal infection rates of 40.0 and 39.8 percent, respectively. 1997 2013-06-11T09:26:09Z 2013-06-11T09:26:09Z Journal Article https://hdl.handle.net/10568/30084 en Open Access Antimicrobial Agents and Chemotherapy;41(7): 1604-1606 |
| spellingShingle | trypanosoma congolense drugs resistance to chemicals Peregrine, A.S. Gray, M.A. Moloo, S.K. Cross-resistance associated with development resistance to isometamidium in a clone of Trypanosoma congolense |
| title | Cross-resistance associated with development resistance to isometamidium in a clone of Trypanosoma congolense |
| title_full | Cross-resistance associated with development resistance to isometamidium in a clone of Trypanosoma congolense |
| title_fullStr | Cross-resistance associated with development resistance to isometamidium in a clone of Trypanosoma congolense |
| title_full_unstemmed | Cross-resistance associated with development resistance to isometamidium in a clone of Trypanosoma congolense |
| title_short | Cross-resistance associated with development resistance to isometamidium in a clone of Trypanosoma congolense |
| title_sort | cross resistance associated with development resistance to isometamidium in a clone of trypanosoma congolense |
| topic | trypanosoma congolense drugs resistance to chemicals |
| url | https://hdl.handle.net/10568/30084 |
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