Characterisation of a monoclonal antibody recognising the CD3 epsilon chain of the bovine T cell receptor complex
The characterisation of a monoclonal antibody (mAb), designated MM1A, which reacts with an antigen molecule on the surface of bovine alfa beta and gama delta TcR+ T cells is described. The mAb immunoprecipitated a series of polypeptides of 21 kDa, 22 kDa, 36 kDa and 44 kDa which is consistent with i...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Elsevier
1998
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/29861 |
| _version_ | 1855514883238395904 |
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| author | MacHugh, Niall D. Mburu, J.K. Hamilton, M.J. Davis, W.C. |
| author_browse | Davis, W.C. Hamilton, M.J. MacHugh, Niall D. Mburu, J.K. |
| author_facet | MacHugh, Niall D. Mburu, J.K. Hamilton, M.J. Davis, W.C. |
| author_sort | MacHugh, Niall D. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The characterisation of a monoclonal antibody (mAb), designated MM1A, which reacts with an antigen molecule on the surface of bovine alfa beta and gama delta TcR+ T cells is described. The mAb immunoprecipitated a series of polypeptides of 21 kDa, 22 kDa, 36 kDa and 44 kDa which is consistent with it recognising the TcR/CD3 complex. COS cells, transfected with a cDNA encoding the bovine CD3e chain, reacted with mAb MM1A indicating that the epitope recognised is on the chain of the complex and confirming the mAb recognised bovine CD3. |
| format | Journal Article |
| id | CGSpace29861 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1998 |
| publishDateRange | 1998 |
| publishDateSort | 1998 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace298612024-04-25T06:00:18Z Characterisation of a monoclonal antibody recognising the CD3 epsilon chain of the bovine T cell receptor complex MacHugh, Niall D. Mburu, J.K. Hamilton, M.J. Davis, W.C. bovinae monoclonal antibodies genetic transformation immunology The characterisation of a monoclonal antibody (mAb), designated MM1A, which reacts with an antigen molecule on the surface of bovine alfa beta and gama delta TcR+ T cells is described. The mAb immunoprecipitated a series of polypeptides of 21 kDa, 22 kDa, 36 kDa and 44 kDa which is consistent with it recognising the TcR/CD3 complex. COS cells, transfected with a cDNA encoding the bovine CD3e chain, reacted with mAb MM1A indicating that the epitope recognised is on the chain of the complex and confirming the mAb recognised bovine CD3. 1998-02 2013-06-11T09:25:11Z 2013-06-11T09:25:11Z Journal Article https://hdl.handle.net/10568/29861 en Limited Access Elsevier Veterinary Immunology and Immunopathology;61(1): 25-35 |
| spellingShingle | bovinae monoclonal antibodies genetic transformation immunology MacHugh, Niall D. Mburu, J.K. Hamilton, M.J. Davis, W.C. Characterisation of a monoclonal antibody recognising the CD3 epsilon chain of the bovine T cell receptor complex |
| title | Characterisation of a monoclonal antibody recognising the CD3 epsilon chain of the bovine T cell receptor complex |
| title_full | Characterisation of a monoclonal antibody recognising the CD3 epsilon chain of the bovine T cell receptor complex |
| title_fullStr | Characterisation of a monoclonal antibody recognising the CD3 epsilon chain of the bovine T cell receptor complex |
| title_full_unstemmed | Characterisation of a monoclonal antibody recognising the CD3 epsilon chain of the bovine T cell receptor complex |
| title_short | Characterisation of a monoclonal antibody recognising the CD3 epsilon chain of the bovine T cell receptor complex |
| title_sort | characterisation of a monoclonal antibody recognising the cd3 epsilon chain of the bovine t cell receptor complex |
| topic | bovinae monoclonal antibodies genetic transformation immunology |
| url | https://hdl.handle.net/10568/29861 |
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