Studies on Trypanosoma (nannomonas) congolense. III. Antigenic variation in three cyclically transmitted stocks
Cyclical transmission of different variable antigen types of Trypanosoma congolense STIB 228 resulted in the development of metacyclic trypanosome populations which were similar in their variable antigen composition as judged by immunofluorescence and neutralization assays. The variable antigen type...
| Autores principales: | , , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Cambridge University Press
1980
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/29424 |
| _version_ | 1855514544108994560 |
|---|---|
| author | Nantulya, V.M. Doyle, J.J. Jenni, L. |
| author_browse | Doyle, J.J. Jenni, L. Nantulya, V.M. |
| author_facet | Nantulya, V.M. Doyle, J.J. Jenni, L. |
| author_sort | Nantulya, V.M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Cyclical transmission of different variable antigen types of Trypanosoma congolense STIB 228 resulted in the development of metacyclic trypanosome populations which were similar in their variable antigen composition as judged by immunofluorescence and neutralization assays. The variable antigen types present in the ingested bloodstream populations were not found in the metacyclic populations. The bloodstream populations which were obtained from cyclically infected, irradiated (900 rad.) mice contained variable antigen types which were not present in the corresponding metacyclic populations. When derivatives of 2 other stocks of T. congolense, isolated in a different area of Tanzania, underwent cyclical development in the tsetse fly, the metacyclic populations of each stock also had a characteristic variable antigen composition. The metacyclic populations of the 3 stocks were, however, completely dissimilar in variable antigen composition. Simultaneous infection of tsetse flies with a mixture of different stocks resulted in the concurrent production of metacyclic trypanosomes which contained the characteristic variable antigen types of each stock. The effect of cyclical transmission on the process of antigenic variation in T. congolense infections is therefore similar to that in T. brucei infections. |
| format | Journal Article |
| id | CGSpace29424 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1980 |
| publishDateRange | 1980 |
| publishDateSort | 1980 |
| publisher | Cambridge University Press |
| publisherStr | Cambridge University Press |
| record_format | dspace |
| spelling | CGSpace294242024-11-15T08:52:05Z Studies on Trypanosoma (nannomonas) congolense. III. Antigenic variation in three cyclically transmitted stocks Nantulya, V.M. Doyle, J.J. Jenni, L. trypanosoma congolense antigens variants immunization mice disease control disease transmission infectious diseases parasitology Cyclical transmission of different variable antigen types of Trypanosoma congolense STIB 228 resulted in the development of metacyclic trypanosome populations which were similar in their variable antigen composition as judged by immunofluorescence and neutralization assays. The variable antigen types present in the ingested bloodstream populations were not found in the metacyclic populations. The bloodstream populations which were obtained from cyclically infected, irradiated (900 rad.) mice contained variable antigen types which were not present in the corresponding metacyclic populations. When derivatives of 2 other stocks of T. congolense, isolated in a different area of Tanzania, underwent cyclical development in the tsetse fly, the metacyclic populations of each stock also had a characteristic variable antigen composition. The metacyclic populations of the 3 stocks were, however, completely dissimilar in variable antigen composition. Simultaneous infection of tsetse flies with a mixture of different stocks resulted in the concurrent production of metacyclic trypanosomes which contained the characteristic variable antigen types of each stock. The effect of cyclical transmission on the process of antigenic variation in T. congolense infections is therefore similar to that in T. brucei infections. 1980-02 2013-06-11T09:23:31Z 2013-06-11T09:23:31Z Journal Article https://hdl.handle.net/10568/29424 en Limited Access Cambridge University Press Parasitology;80: 123-132 |
| spellingShingle | trypanosoma congolense antigens variants immunization mice disease control disease transmission infectious diseases parasitology Nantulya, V.M. Doyle, J.J. Jenni, L. Studies on Trypanosoma (nannomonas) congolense. III. Antigenic variation in three cyclically transmitted stocks |
| title | Studies on Trypanosoma (nannomonas) congolense. III. Antigenic variation in three cyclically transmitted stocks |
| title_full | Studies on Trypanosoma (nannomonas) congolense. III. Antigenic variation in three cyclically transmitted stocks |
| title_fullStr | Studies on Trypanosoma (nannomonas) congolense. III. Antigenic variation in three cyclically transmitted stocks |
| title_full_unstemmed | Studies on Trypanosoma (nannomonas) congolense. III. Antigenic variation in three cyclically transmitted stocks |
| title_short | Studies on Trypanosoma (nannomonas) congolense. III. Antigenic variation in three cyclically transmitted stocks |
| title_sort | studies on trypanosoma nannomonas congolense iii antigenic variation in three cyclically transmitted stocks |
| topic | trypanosoma congolense antigens variants immunization mice disease control disease transmission infectious diseases parasitology |
| url | https://hdl.handle.net/10568/29424 |
| work_keys_str_mv | AT nantulyavm studiesontrypanosomanannomonascongolenseiiiantigenicvariationinthreecyclicallytransmittedstocks AT doylejj studiesontrypanosomanannomonascongolenseiiiantigenicvariationinthreecyclicallytransmittedstocks AT jennil studiesontrypanosomanannomonascongolenseiiiantigenicvariationinthreecyclicallytransmittedstocks |