Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei brucei by immunostimulants
Administration of the immunostimulantsCorynebacterium parvum, Bacillus Calmette-Guérin(BCG) orBordetella pertussisprior to, or at the same time as, challenge withTrypanosoma congolensesignificantly increased survival times in mice, both of trypano-susceptible (A/J) and trypano-resistant (C57Bl) stra...
| Autores principales: | , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Cambridge University Press
1979
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/29421 |
| _version_ | 1855535086809645056 |
|---|---|
| author | Murray, M. Morrison, W. Ivan |
| author_browse | Morrison, W. Ivan Murray, M. |
| author_facet | Murray, M. Morrison, W. Ivan |
| author_sort | Murray, M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Administration of the immunostimulantsCorynebacterium parvum, Bacillus Calmette-Guérin(BCG) orBordetella pertussisprior to, or at the same time as, challenge withTrypanosoma congolensesignificantly increased survival times in mice, both of trypano-susceptible (A/J) and trypano-resistant (C57Bl) strains. The increased survival time was associated with significant alterations in parasitaemia, which included lengthening of the pre-patent period, a delay in the time taken to reach the first peak of parasitaemia and a reduction in the level of parasitaemia. Similar results were obtained when these strains of mice were challenged withTrypanosoma bruceifollowing pre-treatment withC. parvum. Thus, by the use of immunostimulants it was possible to reduce the susceptibility of mice to trypanosomiasis and the hope is that this can also be achieved with domestic livestock. |
| format | Journal Article |
| id | CGSpace29421 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1979 |
| publishDateRange | 1979 |
| publishDateSort | 1979 |
| publisher | Cambridge University Press |
| publisherStr | Cambridge University Press |
| record_format | dspace |
| spelling | CGSpace294212024-11-15T08:52:55Z Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei brucei by immunostimulants Murray, M. Morrison, W. Ivan trypanosoma congolense mice trypanosoma brucei immunology Administration of the immunostimulantsCorynebacterium parvum, Bacillus Calmette-Guérin(BCG) orBordetella pertussisprior to, or at the same time as, challenge withTrypanosoma congolensesignificantly increased survival times in mice, both of trypano-susceptible (A/J) and trypano-resistant (C57Bl) strains. The increased survival time was associated with significant alterations in parasitaemia, which included lengthening of the pre-patent period, a delay in the time taken to reach the first peak of parasitaemia and a reduction in the level of parasitaemia. Similar results were obtained when these strains of mice were challenged withTrypanosoma bruceifollowing pre-treatment withC. parvum. Thus, by the use of immunostimulants it was possible to reduce the susceptibility of mice to trypanosomiasis and the hope is that this can also be achieved with domestic livestock. 1979-12 2013-06-11T09:23:30Z 2013-06-11T09:23:30Z Journal Article https://hdl.handle.net/10568/29421 en Limited Access Cambridge University Press Parasitology;79: 349-365 |
| spellingShingle | trypanosoma congolense mice trypanosoma brucei immunology Murray, M. Morrison, W. Ivan Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei brucei by immunostimulants |
| title | Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei brucei by immunostimulants |
| title_full | Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei brucei by immunostimulants |
| title_fullStr | Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei brucei by immunostimulants |
| title_full_unstemmed | Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei brucei by immunostimulants |
| title_short | Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei brucei by immunostimulants |
| title_sort | non specific induction of increased resistance in mice to trypanosoma congolense and trypanosoma brucei brucei by immunostimulants |
| topic | trypanosoma congolense mice trypanosoma brucei immunology |
| url | https://hdl.handle.net/10568/29421 |
| work_keys_str_mv | AT murraym nonspecificinductionofincreasedresistanceinmicetotrypanosomacongolenseandtrypanosomabruceibruceibyimmunostimulants AT morrisonwivan nonspecificinductionofincreasedresistanceinmicetotrypanosomacongolenseandtrypanosomabruceibruceibyimmunostimulants |