Immunosuppression in trypanotolerant N'Dama cattle following Trypanosoma congolense infection
Tsetse‐transmitted Trypanosoma congolense infection causes an impairment of in vitro T cell proliferative responses in Boran (Bos indicus) cattle. To assess the importance of this phenomenon as it may relate to the ability of trypanotolerant cattle to control infection with trypanosomes, T cell prol...
| Autores principales: | , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
1993
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/29381 |
| _version_ | 1855526719445794816 |
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| author | Flynn, J.N. Sileghem, M.R. |
| author_browse | Flynn, J.N. Sileghem, M.R. |
| author_facet | Flynn, J.N. Sileghem, M.R. |
| author_sort | Flynn, J.N. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Tsetse‐transmitted Trypanosoma congolense infection causes an impairment of in vitro T cell proliferative responses in Boran (Bos indicus) cattle. To assess the importance of this phenomenon as it may relate to the ability of trypanotolerant cattle to control infection with trypanosomes, T cell proliferative responses to mitogenic stimulus with Concanavalin A were measured in N'Dama (Bos taurus,) cattle throughout infection. The responses of peripheral blood mononuclear cells from Boran and N'Dama cattle were similar. Depressed proliferative responses were observed with cells of both breeds at 12 days post infection, after which the responses returned to levels similar to those recorded pre‐infection. Immunosuppression was also studied in the lymph nodes of a major histocompa‐tibility complex (MHC)‐matched pair of N'Dama cattle. Lymph node cells from the infected animal failed to respond to mitogenic stimulus. Co‐culture experiments in which the cells from this node were mixed with either lymph node cells or peripheral blood mononuclear cells from the non‐infected MHC‐compatible animal revealed the presence of suppressor cells, acting in a prostaglandin‐independent manner, capable of arresting mitogen‐induced T cell proliferation. |
| format | Journal Article |
| id | CGSpace29381 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1993 |
| publishDateRange | 1993 |
| publishDateSort | 1993 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace293812024-05-01T08:17:35Z Immunosuppression in trypanotolerant N'Dama cattle following Trypanosoma congolense infection Flynn, J.N. Sileghem, M.R. trypanosoma congolense infection immunosupression ndama cattle trypanotolerance animal diseases Tsetse‐transmitted Trypanosoma congolense infection causes an impairment of in vitro T cell proliferative responses in Boran (Bos indicus) cattle. To assess the importance of this phenomenon as it may relate to the ability of trypanotolerant cattle to control infection with trypanosomes, T cell proliferative responses to mitogenic stimulus with Concanavalin A were measured in N'Dama (Bos taurus,) cattle throughout infection. The responses of peripheral blood mononuclear cells from Boran and N'Dama cattle were similar. Depressed proliferative responses were observed with cells of both breeds at 12 days post infection, after which the responses returned to levels similar to those recorded pre‐infection. Immunosuppression was also studied in the lymph nodes of a major histocompa‐tibility complex (MHC)‐matched pair of N'Dama cattle. Lymph node cells from the infected animal failed to respond to mitogenic stimulus. Co‐culture experiments in which the cells from this node were mixed with either lymph node cells or peripheral blood mononuclear cells from the non‐infected MHC‐compatible animal revealed the presence of suppressor cells, acting in a prostaglandin‐independent manner, capable of arresting mitogen‐induced T cell proliferation. 1993-09 2013-06-11T09:23:22Z 2013-06-11T09:23:22Z Journal Article https://hdl.handle.net/10568/29381 en Limited Access Wiley Parasite Immunology;15: 547-552 |
| spellingShingle | trypanosoma congolense infection immunosupression ndama cattle trypanotolerance animal diseases Flynn, J.N. Sileghem, M.R. Immunosuppression in trypanotolerant N'Dama cattle following Trypanosoma congolense infection |
| title | Immunosuppression in trypanotolerant N'Dama cattle following Trypanosoma congolense infection |
| title_full | Immunosuppression in trypanotolerant N'Dama cattle following Trypanosoma congolense infection |
| title_fullStr | Immunosuppression in trypanotolerant N'Dama cattle following Trypanosoma congolense infection |
| title_full_unstemmed | Immunosuppression in trypanotolerant N'Dama cattle following Trypanosoma congolense infection |
| title_short | Immunosuppression in trypanotolerant N'Dama cattle following Trypanosoma congolense infection |
| title_sort | immunosuppression in trypanotolerant n dama cattle following trypanosoma congolense infection |
| topic | trypanosoma congolense infection immunosupression ndama cattle trypanotolerance animal diseases |
| url | https://hdl.handle.net/10568/29381 |
| work_keys_str_mv | AT flynnjn immunosuppressionintrypanotolerantndamacattlefollowingtrypanosomacongolenseinfection AT sileghemmr immunosuppressionintrypanotolerantndamacattlefollowingtrypanosomacongolenseinfection |