Evaluation of cytotoxic lymphocytes and their parasite strain specificity from African buffalo infected with Theileria parva
Summary Theileria parva‐reactive cytotoxic lymphocytes and their precursors were examined in the blood of African buffalo infected with T. parva and uninfected African buffalo. Peripheral blood mononuclear cells (PBM) from eight of 11 infected buffalo were found to have potent cytotoxic activity aft...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Wiley
1988
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/29377 |
| _version_ | 1855523396754866176 |
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| author | Baldwin, Cynthia L. Malu, M.N. Grootenhuis, J.G. |
| author_browse | Baldwin, Cynthia L. Grootenhuis, J.G. Malu, M.N. |
| author_facet | Baldwin, Cynthia L. Malu, M.N. Grootenhuis, J.G. |
| author_sort | Baldwin, Cynthia L. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Summary Theileria parva‐reactive cytotoxic lymphocytes and their precursors were examined in the blood of African buffalo infected with T. parva and uninfected African buffalo. Peripheral blood mononuclear cells (PBM) from eight of 11 infected buffalo were found to have potent cytotoxic activity after stimulation with autologous parasitized cells for 6 days in vitro, while PBM from uninfected buffalo or PBM from infected buffalo not stimulated in vitro had no cytotoxic activity. The cytotoxic activity was specific for parasitized cells and genetically restricted since there was no killing on uninfected autologous lymphoblasts and a lower percentage of killing on parasitized allogeneic lymphocytes than on targets of autologous parasitized cells. The cytotoxic cells tested for parasite strain specificity were shown to kill autologous cells transformed with different stocks of both cattle‐derived (T. parva parva) and buffalo‐derived (T. parva lawrencei) parasites. |
| format | Journal Article |
| id | CGSpace29377 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1988 |
| publishDateRange | 1988 |
| publishDateSort | 1988 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace293772024-05-01T08:16:57Z Evaluation of cytotoxic lymphocytes and their parasite strain specificity from African buffalo infected with Theileria parva Baldwin, Cynthia L. Malu, M.N. Grootenhuis, J.G. lymphocytes parasites buffaloes infection theileria parva animal diseases Summary Theileria parva‐reactive cytotoxic lymphocytes and their precursors were examined in the blood of African buffalo infected with T. parva and uninfected African buffalo. Peripheral blood mononuclear cells (PBM) from eight of 11 infected buffalo were found to have potent cytotoxic activity after stimulation with autologous parasitized cells for 6 days in vitro, while PBM from uninfected buffalo or PBM from infected buffalo not stimulated in vitro had no cytotoxic activity. The cytotoxic activity was specific for parasitized cells and genetically restricted since there was no killing on uninfected autologous lymphoblasts and a lower percentage of killing on parasitized allogeneic lymphocytes than on targets of autologous parasitized cells. The cytotoxic cells tested for parasite strain specificity were shown to kill autologous cells transformed with different stocks of both cattle‐derived (T. parva parva) and buffalo‐derived (T. parva lawrencei) parasites. 1988-07 2013-06-11T09:23:21Z 2013-06-11T09:23:21Z Journal Article https://hdl.handle.net/10568/29377 en Limited Access Wiley Parasite Immunology;10: 393-403 |
| spellingShingle | lymphocytes parasites buffaloes infection theileria parva animal diseases Baldwin, Cynthia L. Malu, M.N. Grootenhuis, J.G. Evaluation of cytotoxic lymphocytes and their parasite strain specificity from African buffalo infected with Theileria parva |
| title | Evaluation of cytotoxic lymphocytes and their parasite strain specificity from African buffalo infected with Theileria parva |
| title_full | Evaluation of cytotoxic lymphocytes and their parasite strain specificity from African buffalo infected with Theileria parva |
| title_fullStr | Evaluation of cytotoxic lymphocytes and their parasite strain specificity from African buffalo infected with Theileria parva |
| title_full_unstemmed | Evaluation of cytotoxic lymphocytes and their parasite strain specificity from African buffalo infected with Theileria parva |
| title_short | Evaluation of cytotoxic lymphocytes and their parasite strain specificity from African buffalo infected with Theileria parva |
| title_sort | evaluation of cytotoxic lymphocytes and their parasite strain specificity from african buffalo infected with theileria parva |
| topic | lymphocytes parasites buffaloes infection theileria parva animal diseases |
| url | https://hdl.handle.net/10568/29377 |
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