Regulation of the growth and differentiation of Trypanosoma (Trypanozoon) brucei brucei in resistant (C57B1/6) and susceptible (C3H/He) mice
Summary While Trypanosoma brucei brucei GUTat 3 were equally infective for C3H/Heand for C57B1/6 mice at doses ranging from 5 to 5 × 103 organisms and had similar prepatent periods in both strains of mice, infected C57B1/6 mice displayed lower parasitaemia, shorter times to parasite wave remission a...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Wiley
1983
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/29363 |
| _version_ | 1855517113823789056 |
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| author | Black, Samuel J. Sendashoga, Cyrie N. Lalor, P.A. Whitelaw, D.D. Jack, R.M. Morrison, W. Ivan Murray, M. |
| author_browse | Black, Samuel J. Jack, R.M. Lalor, P.A. Morrison, W. Ivan Murray, M. Sendashoga, Cyrie N. Whitelaw, D.D. |
| author_facet | Black, Samuel J. Sendashoga, Cyrie N. Lalor, P.A. Whitelaw, D.D. Jack, R.M. Morrison, W. Ivan Murray, M. |
| author_sort | Black, Samuel J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Summary While Trypanosoma brucei brucei GUTat 3 were equally infective for C3H/Heand for C57B1/6 mice at doses ranging from 5 to 5 × 103 organisms and had similar prepatent periods in both strains of mice, infected C57B1/6 mice displayed lower parasitaemia, shorter times to parasite wave remission and survived for a longer time than infected C3H/He mice. Parasite growth and differentiation rates and host immune responses were similar for the first 5 days in both strains of mice after infection with 103 T.b.brucei GUTat 3 but, thereafter, parasite differentiation proceeded more rapidly and specific antibodies reached higher titres in C57B1/6 than in C3H/He mice. In contrast, parasite growth and differentiation rates were similar in irradiated mice of both strains. Furthermore, following inoculation of intact mice with irradiated T.b.brucei GUTat 3, C3H/Hemice actually mounted higher titred antibody responses than C57B1/6 mice showing that they were not intrinsically defective in their capacity to respond to GUTat 3 antigens. Parasite differentiation occurred at the same rate in irradiated (650r) C57B1/6 mice and in irradiated C57B1/6 mice reconstituted with syngeneic spleen cells although T.b.brucei GUTat 3 specific antibody was detected in the latter mice prior to peak parasitaemia. Furthermore, it was shown directly in C57B1/6 mice that there was no selective destruction of slender form T.b.brucei GUTat 3 parasites during the phase of accumulation of stumpy form parasites. These studies indicate that the more rapid differentiation of T.b.brucei GUTat 3 parasites in infected C57B1/6 mice as compared to infected C3H/Hemice was unlikely to be directly related to the more efficient antibody response in the infected C57B1/6 mice. The observations suggest that there might be an association between host mechanisms which regulate differentiation of T.b.brucei parasites and those which regulate antibody responses. |
| format | Journal Article |
| id | CGSpace29363 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1983 |
| publishDateRange | 1983 |
| publishDateSort | 1983 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace293632024-05-01T08:15:28Z Regulation of the growth and differentiation of Trypanosoma (Trypanozoon) brucei brucei in resistant (C57B1/6) and susceptible (C3H/He) mice Black, Samuel J. Sendashoga, Cyrie N. Lalor, P.A. Whitelaw, D.D. Jack, R.M. Morrison, W. Ivan Murray, M. trypanosoma brucei disease resistance mice animal diseases immunology parasitology Summary While Trypanosoma brucei brucei GUTat 3 were equally infective for C3H/Heand for C57B1/6 mice at doses ranging from 5 to 5 × 103 organisms and had similar prepatent periods in both strains of mice, infected C57B1/6 mice displayed lower parasitaemia, shorter times to parasite wave remission and survived for a longer time than infected C3H/He mice. Parasite growth and differentiation rates and host immune responses were similar for the first 5 days in both strains of mice after infection with 103 T.b.brucei GUTat 3 but, thereafter, parasite differentiation proceeded more rapidly and specific antibodies reached higher titres in C57B1/6 than in C3H/He mice. In contrast, parasite growth and differentiation rates were similar in irradiated mice of both strains. Furthermore, following inoculation of intact mice with irradiated T.b.brucei GUTat 3, C3H/Hemice actually mounted higher titred antibody responses than C57B1/6 mice showing that they were not intrinsically defective in their capacity to respond to GUTat 3 antigens. Parasite differentiation occurred at the same rate in irradiated (650r) C57B1/6 mice and in irradiated C57B1/6 mice reconstituted with syngeneic spleen cells although T.b.brucei GUTat 3 specific antibody was detected in the latter mice prior to peak parasitaemia. Furthermore, it was shown directly in C57B1/6 mice that there was no selective destruction of slender form T.b.brucei GUTat 3 parasites during the phase of accumulation of stumpy form parasites. These studies indicate that the more rapid differentiation of T.b.brucei GUTat 3 parasites in infected C57B1/6 mice as compared to infected C3H/Hemice was unlikely to be directly related to the more efficient antibody response in the infected C57B1/6 mice. The observations suggest that there might be an association between host mechanisms which regulate differentiation of T.b.brucei parasites and those which regulate antibody responses. 1983-09 2013-06-11T09:23:18Z 2013-06-11T09:23:18Z Journal Article https://hdl.handle.net/10568/29363 en Limited Access Wiley Parasite Immunology;5: 465-478 |
| spellingShingle | trypanosoma brucei disease resistance mice animal diseases immunology parasitology Black, Samuel J. Sendashoga, Cyrie N. Lalor, P.A. Whitelaw, D.D. Jack, R.M. Morrison, W. Ivan Murray, M. Regulation of the growth and differentiation of Trypanosoma (Trypanozoon) brucei brucei in resistant (C57B1/6) and susceptible (C3H/He) mice |
| title | Regulation of the growth and differentiation of Trypanosoma (Trypanozoon) brucei brucei in resistant (C57B1/6) and susceptible (C3H/He) mice |
| title_full | Regulation of the growth and differentiation of Trypanosoma (Trypanozoon) brucei brucei in resistant (C57B1/6) and susceptible (C3H/He) mice |
| title_fullStr | Regulation of the growth and differentiation of Trypanosoma (Trypanozoon) brucei brucei in resistant (C57B1/6) and susceptible (C3H/He) mice |
| title_full_unstemmed | Regulation of the growth and differentiation of Trypanosoma (Trypanozoon) brucei brucei in resistant (C57B1/6) and susceptible (C3H/He) mice |
| title_short | Regulation of the growth and differentiation of Trypanosoma (Trypanozoon) brucei brucei in resistant (C57B1/6) and susceptible (C3H/He) mice |
| title_sort | regulation of the growth and differentiation of trypanosoma trypanozoon brucei brucei in resistant c57b1 6 and susceptible c3h he mice |
| topic | trypanosoma brucei disease resistance mice animal diseases immunology parasitology |
| url | https://hdl.handle.net/10568/29363 |
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