Polyamine oxidase-mediated killing of African trypanosomes
African trypanosomes, Trypanosoma brucei brucei, T. vivax and T. congolense, were killed when incubated in vitro with ruminant sera in the presence of exogeneous spermidine, and were non‐infective for mice. Purified polyamine oxidase in the presence of spermidine‐mediated similar killing of trypanos...
| Autores principales: | , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
1982
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/29344 |
| _version_ | 1855526134157934592 |
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| author | Ferrante, A. Allison, C. Hirumi, H. |
| author_browse | Allison, C. Ferrante, A. Hirumi, H. |
| author_facet | Ferrante, A. Allison, C. Hirumi, H. |
| author_sort | Ferrante, A. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | African trypanosomes, Trypanosoma brucei brucei, T. vivax and T. congolense, were killed when incubated in vitro with ruminant sera in the presence of exogeneous spermidine, and were non‐infective for mice. Purified polyamine oxidase in the presence of spermidine‐mediated similar killing of trypanosomes. The abundance of polyamine oxidase activity in ruminant sera which can react with polyamines to produce products with cytotoxic properties may explain the trypanosome killing. This system may contribute to non‐specific parasite killing in vivo. |
| format | Journal Article |
| id | CGSpace29344 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1982 |
| publishDateRange | 1982 |
| publishDateSort | 1982 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace293442024-05-01T08:17:32Z Polyamine oxidase-mediated killing of African trypanosomes Ferrante, A. Allison, C. Hirumi, H. trypanosomes (phytomonas) African trypanosomes, Trypanosoma brucei brucei, T. vivax and T. congolense, were killed when incubated in vitro with ruminant sera in the presence of exogeneous spermidine, and were non‐infective for mice. Purified polyamine oxidase in the presence of spermidine‐mediated similar killing of trypanosomes. The abundance of polyamine oxidase activity in ruminant sera which can react with polyamines to produce products with cytotoxic properties may explain the trypanosome killing. This system may contribute to non‐specific parasite killing in vivo. 1982-09 2013-06-11T09:23:15Z 2013-06-11T09:23:15Z Journal Article https://hdl.handle.net/10568/29344 en Limited Access Wiley Parasite Immunology;4: 349-354 |
| spellingShingle | trypanosomes (phytomonas) Ferrante, A. Allison, C. Hirumi, H. Polyamine oxidase-mediated killing of African trypanosomes |
| title | Polyamine oxidase-mediated killing of African trypanosomes |
| title_full | Polyamine oxidase-mediated killing of African trypanosomes |
| title_fullStr | Polyamine oxidase-mediated killing of African trypanosomes |
| title_full_unstemmed | Polyamine oxidase-mediated killing of African trypanosomes |
| title_short | Polyamine oxidase-mediated killing of African trypanosomes |
| title_sort | polyamine oxidase mediated killing of african trypanosomes |
| topic | trypanosomes (phytomonas) |
| url | https://hdl.handle.net/10568/29344 |
| work_keys_str_mv | AT ferrantea polyamineoxidasemediatedkillingofafricantrypanosomes AT allisonc polyamineoxidasemediatedkillingofafricantrypanosomes AT hirumih polyamineoxidasemediatedkillingofafricantrypanosomes |