Confirmation and dissection of QTL controlling resistance to malaria in mice
We developed an F(11) AIL population from an F(1) cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F(11) mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatellite...
| Autores principales: | , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Springer
2004
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/29204 |
| _version_ | 1855525593543606272 |
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| author | Hernández Valladares, M. Naessens, Jan Gibson, John P. Musoke, A.J. Nagda, S.M. Rihet, P. Ole-MoiYoi, O.K. Iraqi, F.A. |
| author_browse | Gibson, John P. Hernández Valladares, M. Iraqi, F.A. Musoke, A.J. Naessens, Jan Nagda, S.M. Ole-MoiYoi, O.K. Rihet, P. |
| author_facet | Hernández Valladares, M. Naessens, Jan Gibson, John P. Musoke, A.J. Nagda, S.M. Rihet, P. Ole-MoiYoi, O.K. Iraqi, F.A. |
| author_sort | Hernández Valladares, M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | We developed an F(11) AIL population from an F(1) cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F(11) mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatellite markers on Chromosomes (Chrs) 5, 8, and 17. QTL originally detected in backcross and F(2) populations were confirmed on the three chromosomes within narrower genomic regions, by maximum likelihood and regression analyses. Each of the previously mapped QTL on Chrs 5 and 17 resolved into two linked QTLs. The distal and proximal QTLs on Chrs 5 and 17, respectively, map to the previously reported QTL. |
| format | Journal Article |
| id | CGSpace29204 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2004 |
| publishDateRange | 2004 |
| publishDateSort | 2004 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace292042023-12-08T19:36:04Z Confirmation and dissection of QTL controlling resistance to malaria in mice Hernández Valladares, M. Naessens, Jan Gibson, John P. Musoke, A.J. Nagda, S.M. Rihet, P. Ole-MoiYoi, O.K. Iraqi, F.A. malaria mice genetic resistance phenotypes microsatellites genetic markers chromosomes genomes We developed an F(11) AIL population from an F(1) cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F(11) mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatellite markers on Chromosomes (Chrs) 5, 8, and 17. QTL originally detected in backcross and F(2) populations were confirmed on the three chromosomes within narrower genomic regions, by maximum likelihood and regression analyses. Each of the previously mapped QTL on Chrs 5 and 17 resolved into two linked QTLs. The distal and proximal QTLs on Chrs 5 and 17, respectively, map to the previously reported QTL. 2004-05-01 2013-06-11T09:22:46Z 2013-06-11T09:22:46Z Journal Article https://hdl.handle.net/10568/29204 en Limited Access Springer Mammalian Genome;15(5): 390-398 |
| spellingShingle | malaria mice genetic resistance phenotypes microsatellites genetic markers chromosomes genomes Hernández Valladares, M. Naessens, Jan Gibson, John P. Musoke, A.J. Nagda, S.M. Rihet, P. Ole-MoiYoi, O.K. Iraqi, F.A. Confirmation and dissection of QTL controlling resistance to malaria in mice |
| title | Confirmation and dissection of QTL controlling resistance to malaria in mice |
| title_full | Confirmation and dissection of QTL controlling resistance to malaria in mice |
| title_fullStr | Confirmation and dissection of QTL controlling resistance to malaria in mice |
| title_full_unstemmed | Confirmation and dissection of QTL controlling resistance to malaria in mice |
| title_short | Confirmation and dissection of QTL controlling resistance to malaria in mice |
| title_sort | confirmation and dissection of qtl controlling resistance to malaria in mice |
| topic | malaria mice genetic resistance phenotypes microsatellites genetic markers chromosomes genomes |
| url | https://hdl.handle.net/10568/29204 |
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