Cytokine mRNA profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite trypanosoma congolense: Protective role for interleukin-4
African trypanosomes are important pathogens of both humans and livestock. We investigated the association of cytokine responses with disease susceptibility in Trypanosoma congolense-infected cattle. Changes in interleukin (IL)-1 beta, IL-2, IL-4, IL-5, IL-6, IL-12 p40, tumor necrosis factor-alpha (...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Mary Ann Liebert Inc
1999
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/28927 |
| _version_ | 1855528533849276416 |
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| author | Mertens, B. Taylor, K. Muriuki, C. Rocchi, M. |
| author_browse | Mertens, B. Muriuki, C. Rocchi, M. Taylor, K. |
| author_facet | Mertens, B. Taylor, K. Muriuki, C. Rocchi, M. |
| author_sort | Mertens, B. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | African trypanosomes are important pathogens of both humans and livestock. We investigated the association of cytokine responses with disease susceptibility in Trypanosoma congolense-infected cattle. Changes in interleukin (IL)-1 beta, IL-2, IL-4, IL-5, IL-6, IL-12 p40, tumor necrosis factor-alpha (TFN-alpha) CD40L, and transforming growth factor-beta (TGF-beta) gene expression were compared in peripheral blood mononuclear cells of infected trypanotolerant N'Dama (Bos taurus) and trypanosusceptible Boran (Bos indicus) cattle. Results revealed that IL-2 transcription was decreased in both breeds of cattle at 21 days after infection. IL-12 p40 mRNA expression was increased in N'Dama cattle at 21 days after infection and at a later time in Boran cattle. The highest IL-4 mRNA expression was observed at 32 days after infection in N'Dama cattle. IL-6 mRNA expression increased in Boran cattle at 11 days after infection and was elevated at 21 and 32 days after infection in both breeds. Transcripts for IL-5 were barely detectable throughout the experimental period in both Boran and N'Dama cattle. Expression of TNF-alfa, IL-1 beta mRNA did not change notably during the course of infection. In summary, differences in the expression of IL-4 and IL-6 mRNA were identifed between the two breeds of cattle during infection with T. congolense, suggesting a possible protective role for IL-4 and a disease-promoting role for IL-6 in bovine trypanosomosis. |
| format | Journal Article |
| id | CGSpace28927 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1999 |
| publishDateRange | 1999 |
| publishDateSort | 1999 |
| publisher | Mary Ann Liebert Inc |
| publisherStr | Mary Ann Liebert Inc |
| record_format | dspace |
| spelling | CGSpace289272023-09-10T02:06:23Z Cytokine mRNA profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite trypanosoma congolense: Protective role for interleukin-4 Mertens, B. Taylor, K. Muriuki, C. Rocchi, M. cattle trypanosomiasis disease resistance protozoal infections trypanosoma congolense interleukins African trypanosomes are important pathogens of both humans and livestock. We investigated the association of cytokine responses with disease susceptibility in Trypanosoma congolense-infected cattle. Changes in interleukin (IL)-1 beta, IL-2, IL-4, IL-5, IL-6, IL-12 p40, tumor necrosis factor-alpha (TFN-alpha) CD40L, and transforming growth factor-beta (TGF-beta) gene expression were compared in peripheral blood mononuclear cells of infected trypanotolerant N'Dama (Bos taurus) and trypanosusceptible Boran (Bos indicus) cattle. Results revealed that IL-2 transcription was decreased in both breeds of cattle at 21 days after infection. IL-12 p40 mRNA expression was increased in N'Dama cattle at 21 days after infection and at a later time in Boran cattle. The highest IL-4 mRNA expression was observed at 32 days after infection in N'Dama cattle. IL-6 mRNA expression increased in Boran cattle at 11 days after infection and was elevated at 21 and 32 days after infection in both breeds. Transcripts for IL-5 were barely detectable throughout the experimental period in both Boran and N'Dama cattle. Expression of TNF-alfa, IL-1 beta mRNA did not change notably during the course of infection. In summary, differences in the expression of IL-4 and IL-6 mRNA were identifed between the two breeds of cattle during infection with T. congolense, suggesting a possible protective role for IL-4 and a disease-promoting role for IL-6 in bovine trypanosomosis. 1999-01 2013-05-06T07:01:46Z 2013-05-06T07:01:46Z Journal Article https://hdl.handle.net/10568/28927 en Limited Access Mary Ann Liebert Inc Journal of Interferon and Cytokine Research;19(1): 59-65 |
| spellingShingle | cattle trypanosomiasis disease resistance protozoal infections trypanosoma congolense interleukins Mertens, B. Taylor, K. Muriuki, C. Rocchi, M. Cytokine mRNA profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite trypanosoma congolense: Protective role for interleukin-4 |
| title | Cytokine mRNA profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite trypanosoma congolense: Protective role for interleukin-4 |
| title_full | Cytokine mRNA profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite trypanosoma congolense: Protective role for interleukin-4 |
| title_fullStr | Cytokine mRNA profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite trypanosoma congolense: Protective role for interleukin-4 |
| title_full_unstemmed | Cytokine mRNA profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite trypanosoma congolense: Protective role for interleukin-4 |
| title_short | Cytokine mRNA profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite trypanosoma congolense: Protective role for interleukin-4 |
| title_sort | cytokine mrna profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite trypanosoma congolense protective role for interleukin 4 |
| topic | cattle trypanosomiasis disease resistance protozoal infections trypanosoma congolense interleukins |
| url | https://hdl.handle.net/10568/28927 |
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