The role of duplication in the expression of a variable surface glycoprotein of Trypanosoma brucei
The variable surface glycoprotein (VSG) genes of Trypanosoma brucei have been classified into two groups depending upon whether or not duplication of the genes is observed when they are expressed. We report here the observation of duplication apparently linked to espression of the ILTaT 1.3 gene in...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Wiley
1984
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/28884 |
| _version_ | 1855527089147478016 |
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| author | Young, J.R. Turner, M.J. Williams, R.O. |
| author_browse | Turner, M.J. Williams, R.O. Young, J.R. |
| author_facet | Young, J.R. Turner, M.J. Williams, R.O. |
| author_sort | Young, J.R. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The variable surface glycoprotein (VSG) genes of Trypanosoma brucei have been classified into two groups depending upon whether or not duplication of the genes is observed when they are expressed. We report here the observation of duplication apparently linked to espression of the ILTaT 1.3 gene in the ETaR 1 trypanosome stock. In the ILTaR 1 stock, expression of the ILTaT 1.3 VSG did not involve a new duplication, but instead activation of a preexisting gene copy that had been apparently generated earlier by a duplication event analogous to that directly observed in the ETaR 1 trypanosomes. The results suggest that the well‐characterised gene duplications found with other VSG genes are common to all VSG genes but are not directly responsible for controlling expression. All currently available data can be accomodated by a model that assumes that gene duplication and replacement occurs independently of antigenic switching. |
| format | Journal Article |
| id | CGSpace28884 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1984 |
| publishDateRange | 1984 |
| publishDateSort | 1984 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace288842024-05-01T08:17:42Z The role of duplication in the expression of a variable surface glycoprotein of Trypanosoma brucei Young, J.R. Turner, M.J. Williams, R.O. trypanosoma brucei glycoproteins The variable surface glycoprotein (VSG) genes of Trypanosoma brucei have been classified into two groups depending upon whether or not duplication of the genes is observed when they are expressed. We report here the observation of duplication apparently linked to espression of the ILTaT 1.3 gene in the ETaR 1 trypanosome stock. In the ILTaR 1 stock, expression of the ILTaT 1.3 VSG did not involve a new duplication, but instead activation of a preexisting gene copy that had been apparently generated earlier by a duplication event analogous to that directly observed in the ETaR 1 trypanosomes. The results suggest that the well‐characterised gene duplications found with other VSG genes are common to all VSG genes but are not directly responsible for controlling expression. All currently available data can be accomodated by a model that assumes that gene duplication and replacement occurs independently of antigenic switching. 1984 2013-05-06T07:01:39Z 2013-05-06T07:01:39Z Journal Article https://hdl.handle.net/10568/28884 en Limited Access Wiley Journal of Cellular Biochemistry;24: 287-295 |
| spellingShingle | trypanosoma brucei glycoproteins Young, J.R. Turner, M.J. Williams, R.O. The role of duplication in the expression of a variable surface glycoprotein of Trypanosoma brucei |
| title | The role of duplication in the expression of a variable surface glycoprotein of Trypanosoma brucei |
| title_full | The role of duplication in the expression of a variable surface glycoprotein of Trypanosoma brucei |
| title_fullStr | The role of duplication in the expression of a variable surface glycoprotein of Trypanosoma brucei |
| title_full_unstemmed | The role of duplication in the expression of a variable surface glycoprotein of Trypanosoma brucei |
| title_short | The role of duplication in the expression of a variable surface glycoprotein of Trypanosoma brucei |
| title_sort | role of duplication in the expression of a variable surface glycoprotein of trypanosoma brucei |
| topic | trypanosoma brucei glycoproteins |
| url | https://hdl.handle.net/10568/28884 |
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