Microsatellite typing reveals strong genetic structure of Schistosoma mansoni from localities in Kenya
Genetic diversity and population structure of seven populations of Schistosoma mansoni sampled in Kenya were assessed using five microsatellite markers. The mean number of alleles per locus, expected heterozygosity in Hardy-Weinberg equilibrium and pairwise FST values ranged from 5.2 to 10.7, 0.5-0....
| Autores principales: | , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2006
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/28770 |
| _version_ | 1855530337324498944 |
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| author | Agola, L.E. Mburu, D.N. DeJong, R.J. Mungai, B.N. Muluvi, G.M. Njagi, E.N.M. Loker, E.S. Mkoji, G.M. |
| author_browse | Agola, L.E. DeJong, R.J. Loker, E.S. Mburu, D.N. Mkoji, G.M. Muluvi, G.M. Mungai, B.N. Njagi, E.N.M. |
| author_facet | Agola, L.E. Mburu, D.N. DeJong, R.J. Mungai, B.N. Muluvi, G.M. Njagi, E.N.M. Loker, E.S. Mkoji, G.M. |
| author_sort | Agola, L.E. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Genetic diversity and population structure of seven populations of Schistosoma mansoni sampled in Kenya were assessed using five microsatellite markers. The mean number of alleles per locus, expected heterozygosity in Hardy-Weinberg equilibrium and pairwise FST values ranged from 5.2 to 10.7, 0.5-0.8 and 3.6-27.3%, respectively. These data reveal that S. mansoni populations in Kenyan have relatively high levels of genetic diversity and is significantly differentiated. Our data combined with information on biogeography support the hypothesis that the strong genetic structure in Kenyan schistosomes is as a result of limited gene flow and large population sizes. Resistance to anthelminthics has not been reported among the Kenyan schistosomes, we hypothesize that this is probably due to the very little gene flow among populations, thereby limiting opportunities for the spread of rare alleles that might confer resistance to the drugs. |
| format | Journal Article |
| id | CGSpace28770 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2006 |
| publishDateRange | 2006 |
| publishDateSort | 2006 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace287702023-12-08T19:36:04Z Microsatellite typing reveals strong genetic structure of Schistosoma mansoni from localities in Kenya Agola, L.E. Mburu, D.N. DeJong, R.J. Mungai, B.N. Muluvi, G.M. Njagi, E.N.M. Loker, E.S. Mkoji, G.M. schistosoma mansoni microsatellites biodiversity population structure schistosomiasis Genetic diversity and population structure of seven populations of Schistosoma mansoni sampled in Kenya were assessed using five microsatellite markers. The mean number of alleles per locus, expected heterozygosity in Hardy-Weinberg equilibrium and pairwise FST values ranged from 5.2 to 10.7, 0.5-0.8 and 3.6-27.3%, respectively. These data reveal that S. mansoni populations in Kenyan have relatively high levels of genetic diversity and is significantly differentiated. Our data combined with information on biogeography support the hypothesis that the strong genetic structure in Kenyan schistosomes is as a result of limited gene flow and large population sizes. Resistance to anthelminthics has not been reported among the Kenyan schistosomes, we hypothesize that this is probably due to the very little gene flow among populations, thereby limiting opportunities for the spread of rare alleles that might confer resistance to the drugs. 2006-11 2013-05-06T07:01:22Z 2013-05-06T07:01:22Z Journal Article https://hdl.handle.net/10568/28770 en Limited Access Elsevier Infection, Genetics and Evolution;6(6): 484-490 |
| spellingShingle | schistosoma mansoni microsatellites biodiversity population structure schistosomiasis Agola, L.E. Mburu, D.N. DeJong, R.J. Mungai, B.N. Muluvi, G.M. Njagi, E.N.M. Loker, E.S. Mkoji, G.M. Microsatellite typing reveals strong genetic structure of Schistosoma mansoni from localities in Kenya |
| title | Microsatellite typing reveals strong genetic structure of Schistosoma mansoni from localities in Kenya |
| title_full | Microsatellite typing reveals strong genetic structure of Schistosoma mansoni from localities in Kenya |
| title_fullStr | Microsatellite typing reveals strong genetic structure of Schistosoma mansoni from localities in Kenya |
| title_full_unstemmed | Microsatellite typing reveals strong genetic structure of Schistosoma mansoni from localities in Kenya |
| title_short | Microsatellite typing reveals strong genetic structure of Schistosoma mansoni from localities in Kenya |
| title_sort | microsatellite typing reveals strong genetic structure of schistosoma mansoni from localities in kenya |
| topic | schistosoma mansoni microsatellites biodiversity population structure schistosomiasis |
| url | https://hdl.handle.net/10568/28770 |
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