Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen
Initial laboratory trials of an experimental subunit vaccine against Theileria parva based on the 67-kDa major sporozoite surface antigen revealed a range of responses to challenge. We have analyzed convergence in seven sets of monozygotic twins which suggests that genetic factors may have an influe...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
American Society for Microbiology
2004
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/28758 |
| _version_ | 1855536791602331648 |
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| author | Ballingall, Keith T. Luyai, A. Rowlands, G.J. Sales, J. Musoke, A.J. Morzaria, S.P. McKeever, Declan J. |
| author_browse | Ballingall, Keith T. Luyai, A. McKeever, Declan J. Morzaria, S.P. Musoke, A.J. Rowlands, G.J. Sales, J. |
| author_facet | Ballingall, Keith T. Luyai, A. Rowlands, G.J. Sales, J. Musoke, A.J. Morzaria, S.P. McKeever, Declan J. |
| author_sort | Ballingall, Keith T. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Initial laboratory trials of an experimental subunit vaccine against Theileria parva based on the 67-kDa major sporozoite surface antigen revealed a range of responses to challenge. We have analyzed convergence in seven sets of monozygotic twins which suggests that genetic factors may have an influence in determining the degree of protection provided by p67 immunization. In addition, we have examined whether allelic diversity at major histocompatibility complex class II loci influences protection. Analysis of bovine leukocyte antigen DRB3 diversity in 201 animals identified significant associations with vaccine success (DRB3*2703; P = 0.027) and vaccine failure (DRB3*1501; P = 0.013). Furthermore, DRB3*2703 was associated with the likelihood of immunized animals showing little to no clinical signs of disease following challenge. We discuss the acquired and innate immune mechanisms that may be behind the associations described here. |
| format | Journal Article |
| id | CGSpace28758 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2004 |
| publishDateRange | 2004 |
| publishDateSort | 2004 |
| publisher | American Society for Microbiology |
| publisherStr | American Society for Microbiology |
| record_format | dspace |
| spelling | CGSpace287582024-04-25T06:01:36Z Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen Ballingall, Keith T. Luyai, A. Rowlands, G.J. Sales, J. Musoke, A.J. Morzaria, S.P. McKeever, Declan J. major histocompatibility complex bovinae leukocytes antigens genes theileria parva immunization cattle protozoa proteins disease control east coast fever Initial laboratory trials of an experimental subunit vaccine against Theileria parva based on the 67-kDa major sporozoite surface antigen revealed a range of responses to challenge. We have analyzed convergence in seven sets of monozygotic twins which suggests that genetic factors may have an influence in determining the degree of protection provided by p67 immunization. In addition, we have examined whether allelic diversity at major histocompatibility complex class II loci influences protection. Analysis of bovine leukocyte antigen DRB3 diversity in 201 animals identified significant associations with vaccine success (DRB3*2703; P = 0.027) and vaccine failure (DRB3*1501; P = 0.013). Furthermore, DRB3*2703 was associated with the likelihood of immunized animals showing little to no clinical signs of disease following challenge. We discuss the acquired and innate immune mechanisms that may be behind the associations described here. 2004-05 2013-05-06T07:01:21Z 2013-05-06T07:01:21Z Journal Article https://hdl.handle.net/10568/28758 en Limited Access American Society for Microbiology Infection and Immunity;72(5): 2738-2741 |
| spellingShingle | major histocompatibility complex bovinae leukocytes antigens genes theileria parva immunization cattle protozoa proteins disease control east coast fever Ballingall, Keith T. Luyai, A. Rowlands, G.J. Sales, J. Musoke, A.J. Morzaria, S.P. McKeever, Declan J. Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen |
| title | Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen |
| title_full | Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen |
| title_fullStr | Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen |
| title_full_unstemmed | Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen |
| title_short | Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen |
| title_sort | bovine leukocyte antigen major histocompatibility complex class ii drb3 2703 and drb3 1501 alleles are associated with variation in levels of protection against theileria parva challenge following immunization with the sporozoite p67 antigen |
| topic | major histocompatibility complex bovinae leukocytes antigens genes theileria parva immunization cattle protozoa proteins disease control east coast fever |
| url | https://hdl.handle.net/10568/28758 |
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