Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva
The relationship of strain specificity of class I major histocompatibility complex-restricted parasite-specific cytotoxic T lymphocytes (CTL) responses and cross-protection was investigated in an effort to verify the role of CTL in protection. The parasite strain specificity of the CTL responses gen...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
1995
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| Online Access: | https://hdl.handle.net/10568/28751 |
| _version_ | 1855543228986556416 |
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| author | Taracha, E.L.N. Goddeeris, Bruno M. Morzaria, S.P. Morrison, W. Ivan |
| author_browse | Goddeeris, Bruno M. Morrison, W. Ivan Morzaria, S.P. Taracha, E.L.N. |
| author_facet | Taracha, E.L.N. Goddeeris, Bruno M. Morzaria, S.P. Morrison, W. Ivan |
| author_sort | Taracha, E.L.N. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The relationship of strain specificity of class I major histocompatibility complex-restricted parasite-specific cytotoxic T lymphocytes (CTL) responses and cross-protection was investigated in an effort to verify the role of CTL in protection. The parasite strain specificity of the CTL responses generated in 23 cattle immunized with either of 2 immunologically distinct parasite populations was examined, and the susceptibility of individual cattle to challenge with the heterologous parasite population was determined. The frequency of stock-specific or cross-reactive CTL precursor cells (CTLp) in individual animals was measured by a limiting-dilution microassay. A proportion of animals immunized with either parasite exhibited cross-reactive. CTLp, whereas CTLp detected in the remaining animals were specific for the homologous parasite. On challenge with the heterologous stock, those animals with cross-reactive CTLp were solidly protected while those with strain-specific CTLp showed moderate to severe reactions, although many of them recovered. The finding of a close association between strain specificity of the CTL response and protection against challenge provides strong evidence that CTL are important in mediating immunity. |
| format | Journal Article |
| id | CGSpace28751 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1995 |
| publishDateRange | 1995 |
| publishDateSort | 1995 |
| record_format | dspace |
| spelling | CGSpace287512024-01-17T12:58:34Z Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva Taracha, E.L.N. Goddeeris, Bruno M. Morzaria, S.P. Morrison, W. Ivan parasites cattle theileria parva lymphocytes animal diseases The relationship of strain specificity of class I major histocompatibility complex-restricted parasite-specific cytotoxic T lymphocytes (CTL) responses and cross-protection was investigated in an effort to verify the role of CTL in protection. The parasite strain specificity of the CTL responses generated in 23 cattle immunized with either of 2 immunologically distinct parasite populations was examined, and the susceptibility of individual cattle to challenge with the heterologous parasite population was determined. The frequency of stock-specific or cross-reactive CTL precursor cells (CTLp) in individual animals was measured by a limiting-dilution microassay. A proportion of animals immunized with either parasite exhibited cross-reactive. CTLp, whereas CTLp detected in the remaining animals were specific for the homologous parasite. On challenge with the heterologous stock, those animals with cross-reactive CTLp were solidly protected while those with strain-specific CTLp showed moderate to severe reactions, although many of them recovered. The finding of a close association between strain specificity of the CTL response and protection against challenge provides strong evidence that CTL are important in mediating immunity. 1995 2013-05-06T07:01:20Z 2013-05-06T07:01:20Z Journal Article https://hdl.handle.net/10568/28751 en Limited Access Infection and Immunity;63(4): 1258-1262 |
| spellingShingle | parasites cattle theileria parva lymphocytes animal diseases Taracha, E.L.N. Goddeeris, Bruno M. Morzaria, S.P. Morrison, W. Ivan Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva |
| title | Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva |
| title_full | Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva |
| title_fullStr | Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva |
| title_full_unstemmed | Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva |
| title_short | Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva |
| title_sort | parasite strain specificity of precursor cytotoxic t cells in individual animals correlates with cross protection in cattle challenged with theileria parva |
| topic | parasites cattle theileria parva lymphocytes animal diseases |
| url | https://hdl.handle.net/10568/28751 |
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