Identification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution
We describe the characterization of two subsets of bovine gamma delta T cells having distinct cell surface phenotype and tissue distribution. One population expresses the previously described 215000 MW WC1 antigen and is negative for the cell-surface differentiation antigens CD2. CD4, and CD8. The s...
| Autores principales: | , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
1997
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/28704 |
| _version_ | 1855537347756556288 |
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| author | MacHugh, Niall D. Mburu, J.K. Carol, M.J. Wyatt, C.R. Orden, J.A. Davis, W.C. |
| author_browse | Carol, M.J. Davis, W.C. MacHugh, Niall D. Mburu, J.K. Orden, J.A. Wyatt, C.R. |
| author_facet | MacHugh, Niall D. Mburu, J.K. Carol, M.J. Wyatt, C.R. Orden, J.A. Davis, W.C. |
| author_sort | MacHugh, Niall D. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | We describe the characterization of two subsets of bovine gamma delta T cells having distinct cell surface phenotype and tissue distribution. One population expresses the previously described 215000 MW WC1 antigen and is negative for the cell-surface differentiation antigens CD2. CD4, and CD8. The second population expresses CD2 and CD8 but not WC1 and appears to have a T-cell receptor (TCR) rearrangement distinct from that of the WC1+ population. The WC1- population is found in large numbers in spleen and intestine. In addition. This subset is not recognized by a number of monoclonal antibodies (mAbs) specific for TCR families that are well represented in the WC1+_ population. The results indicate that the gamma delta T-cell population in cattle is considerably larger than previously described and that this population can be subdivided into two distinct subsets based on cell-surface phenotype and tissue distribution. |
| format | Journal Article |
| id | CGSpace28704 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1997 |
| publishDateRange | 1997 |
| publishDateSort | 1997 |
| record_format | dspace |
| spelling | CGSpace287042022-01-29T16:16:18Z Identification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution MacHugh, Niall D. Mburu, J.K. Carol, M.J. Wyatt, C.R. Orden, J.A. Davis, W.C. bovinae cells phenotypes genetic transformation We describe the characterization of two subsets of bovine gamma delta T cells having distinct cell surface phenotype and tissue distribution. One population expresses the previously described 215000 MW WC1 antigen and is negative for the cell-surface differentiation antigens CD2. CD4, and CD8. The second population expresses CD2 and CD8 but not WC1 and appears to have a T-cell receptor (TCR) rearrangement distinct from that of the WC1+ population. The WC1- population is found in large numbers in spleen and intestine. In addition. This subset is not recognized by a number of monoclonal antibodies (mAbs) specific for TCR families that are well represented in the WC1+_ population. The results indicate that the gamma delta T-cell population in cattle is considerably larger than previously described and that this population can be subdivided into two distinct subsets based on cell-surface phenotype and tissue distribution. 1997 2013-05-06T07:01:13Z 2013-05-06T07:01:13Z Journal Article https://hdl.handle.net/10568/28704 en Limited Access Immunology;92(2): 340-345 |
| spellingShingle | bovinae cells phenotypes genetic transformation MacHugh, Niall D. Mburu, J.K. Carol, M.J. Wyatt, C.R. Orden, J.A. Davis, W.C. Identification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution |
| title | Identification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution |
| title_full | Identification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution |
| title_fullStr | Identification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution |
| title_full_unstemmed | Identification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution |
| title_short | Identification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution |
| title_sort | identification of two distinct subsets of gamma delta t cells with unique cell surface phenotype and tissue distribution |
| topic | bovinae cells phenotypes genetic transformation |
| url | https://hdl.handle.net/10568/28704 |
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