TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso
We have previously obtained strong evidence for linkage of mild malaria attack to the MHC region, with a peak close to the tumor necrosis factor (TNF) gene. We screened, for polymorphisms, the entire TNF gene in the same sample of 34 families comprising 197 individuals living in a Plasmodium falcipa...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Springer
2005
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/28659 |
| _version_ | 1855542659187212288 |
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| author | Flori, L. Delahaye, N.F. Iraqi, F.A. Hernández Valladares, M. Fumoux, F. Rihet, P. |
| author_browse | Delahaye, N.F. Flori, L. Fumoux, F. Hernández Valladares, M. Iraqi, F.A. Rihet, P. |
| author_facet | Flori, L. Delahaye, N.F. Iraqi, F.A. Hernández Valladares, M. Fumoux, F. Rihet, P. |
| author_sort | Flori, L. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | We have previously obtained strong evidence for linkage of mild malaria attack to the MHC region, with a peak close to the tumor necrosis factor (TNF) gene. We screened, for polymorphisms, the entire TNF gene in the same sample of 34 families comprising 197 individuals living in a Plasmodium falciparum endemic area and we found 17 polymorphisms. In a longitudinal study, we investigated whether the 11 most frequent and informative polymorphisms were associated with mild malaria attack and maximum parasitemia, which was the highest parasitemia in each individual over 2 years. Mild malaria attack and maximum parasitemia were positively correlated. Transmission disequilibrium tests showed nominal evidence for association between TNF-1031, TNF-308, TNF851 and TNF1304 polymorphisms, and mild malaria attack on the one hand, and between TNF-238, TNF851 and TNF1304 polymorphisms, and maximum parasitemia on the other hand. After accounting for multiple tests, we confirmed the association of TNF-238 with maximum parasitemia and the association of TNF1304 and TNF851 with maximum parasitemia and mild malaria attack. The association tests with mild malaria attack suggest a moderate effect of TNF-308 polymorphism. In conclusion, our study suggests that several TNF variants may be part of the genetic determinants for maximum parasitemia and/or mild malaria attack. |
| format | Journal Article |
| id | CGSpace28659 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2005 |
| publishDateRange | 2005 |
| publishDateSort | 2005 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace286592023-12-08T19:36:04Z TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso Flori, L. Delahaye, N.F. Iraqi, F.A. Hernández Valladares, M. Fumoux, F. Rihet, P. malaria cytokines genes genetic polymorphism [polymorphism] population genetics parasites plasmodium falciparum We have previously obtained strong evidence for linkage of mild malaria attack to the MHC region, with a peak close to the tumor necrosis factor (TNF) gene. We screened, for polymorphisms, the entire TNF gene in the same sample of 34 families comprising 197 individuals living in a Plasmodium falciparum endemic area and we found 17 polymorphisms. In a longitudinal study, we investigated whether the 11 most frequent and informative polymorphisms were associated with mild malaria attack and maximum parasitemia, which was the highest parasitemia in each individual over 2 years. Mild malaria attack and maximum parasitemia were positively correlated. Transmission disequilibrium tests showed nominal evidence for association between TNF-1031, TNF-308, TNF851 and TNF1304 polymorphisms, and mild malaria attack on the one hand, and between TNF-238, TNF851 and TNF1304 polymorphisms, and maximum parasitemia on the other hand. After accounting for multiple tests, we confirmed the association of TNF-238 with maximum parasitemia and the association of TNF1304 and TNF851 with maximum parasitemia and mild malaria attack. The association tests with mild malaria attack suggest a moderate effect of TNF-308 polymorphism. In conclusion, our study suggests that several TNF variants may be part of the genetic determinants for maximum parasitemia and/or mild malaria attack. 2005-09-01 2013-05-06T07:01:06Z 2013-05-06T07:01:06Z Journal Article https://hdl.handle.net/10568/28659 en Open Access Springer Genes And Immunity;6(6): 472-480 |
| spellingShingle | malaria cytokines genes genetic polymorphism [polymorphism] population genetics parasites plasmodium falciparum Flori, L. Delahaye, N.F. Iraqi, F.A. Hernández Valladares, M. Fumoux, F. Rihet, P. TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso |
| title | TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso |
| title_full | TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso |
| title_fullStr | TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso |
| title_full_unstemmed | TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso |
| title_short | TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso |
| title_sort | tnf as a malaria candidate gene polymorphism screening and family based association analysis of mild malaria attack and parasitemia in burkina faso |
| topic | malaria cytokines genes genetic polymorphism [polymorphism] population genetics parasites plasmodium falciparum |
| url | https://hdl.handle.net/10568/28659 |
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