The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera
In the present study the methanolic extract of Albizia gummifera was fractionated into various fractions. These fractions were tested against choroquine sensitive (NF54) and resistant (ENT30) strains of Plasmodium falciparum. All other fractions apart from the alkaloidal fraction showed low activity...
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2007
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/28644 |
| _version_ | 1855536107051024384 |
|---|---|
| author | Rukunga, G.M. Muregi, F.W. Tolo, F.M. Omar, S.A. Mwitari, P. Muthaura, C.N. Omlin, F. Lwande, W. Hassanali, A. Githure, J. Iraqi, F.W. Mungai, G.M. Kraus, W. Kofi-Tsekpo, W.M. |
| author_browse | Githure, J. Hassanali, A. Iraqi, F.W. Kofi-Tsekpo, W.M. Kraus, W. Lwande, W. Mungai, G.M. Muregi, F.W. Muthaura, C.N. Mwitari, P. Omar, S.A. Omlin, F. Rukunga, G.M. Tolo, F.M. |
| author_facet | Rukunga, G.M. Muregi, F.W. Tolo, F.M. Omar, S.A. Mwitari, P. Muthaura, C.N. Omlin, F. Lwande, W. Hassanali, A. Githure, J. Iraqi, F.W. Mungai, G.M. Kraus, W. Kofi-Tsekpo, W.M. |
| author_sort | Rukunga, G.M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | In the present study the methanolic extract of Albizia gummifera was fractionated into various fractions. These fractions were tested against choroquine sensitive (NF54) and resistant (ENT30) strains of Plasmodium falciparum. All other fractions apart from the alkaloidal fraction showed low activity with IC 50 above 3 ug/ml. The alkaloidal fraction exhibited strong activity against NF54 and ENT30 with IC 50 of 0.16 ± 0.05 and 0.99 ± 0.06 ug/ml, respectively. Five known spermine alkaloids were isolated from the alkaloidal fraction. These alkaloids exhibited activities against NF54 and ENT30 with IC 50 ranging from 0.09 ± 0.02 to 0.91 ± 0.10 ug/ml. Four of the alkaloids were further evaluated for in vivo activity against rodent malaria parasite Plasmodium berghei. The alkaloids showed percentage chemosuppression of parasitaemia in mice ranging from 43 to 72%. The use of the extracts A. gummifera for treatment of malaria in traditional medicine seems to have a scientific basis. |
| format | Journal Article |
| id | CGSpace28644 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2007 |
| publishDateRange | 2007 |
| publishDateSort | 2007 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace286442024-05-01T08:19:05Z The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera Rukunga, G.M. Muregi, F.W. Tolo, F.M. Omar, S.A. Mwitari, P. Muthaura, C.N. Omlin, F. Lwande, W. Hassanali, A. Githure, J. Iraqi, F.W. Mungai, G.M. Kraus, W. Kofi-Tsekpo, W.M. albizia plasmodium drug plants alkaloids In the present study the methanolic extract of Albizia gummifera was fractionated into various fractions. These fractions were tested against choroquine sensitive (NF54) and resistant (ENT30) strains of Plasmodium falciparum. All other fractions apart from the alkaloidal fraction showed low activity with IC 50 above 3 ug/ml. The alkaloidal fraction exhibited strong activity against NF54 and ENT30 with IC 50 of 0.16 ± 0.05 and 0.99 ± 0.06 ug/ml, respectively. Five known spermine alkaloids were isolated from the alkaloidal fraction. These alkaloids exhibited activities against NF54 and ENT30 with IC 50 ranging from 0.09 ± 0.02 to 0.91 ± 0.10 ug/ml. Four of the alkaloids were further evaluated for in vivo activity against rodent malaria parasite Plasmodium berghei. The alkaloids showed percentage chemosuppression of parasitaemia in mice ranging from 43 to 72%. The use of the extracts A. gummifera for treatment of malaria in traditional medicine seems to have a scientific basis. 2007-12 2013-05-06T07:01:04Z 2013-05-06T07:01:04Z Journal Article https://hdl.handle.net/10568/28644 en Limited Access Elsevier Fitoterapia;78(7-8): 455-459 |
| spellingShingle | albizia plasmodium drug plants alkaloids Rukunga, G.M. Muregi, F.W. Tolo, F.M. Omar, S.A. Mwitari, P. Muthaura, C.N. Omlin, F. Lwande, W. Hassanali, A. Githure, J. Iraqi, F.W. Mungai, G.M. Kraus, W. Kofi-Tsekpo, W.M. The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera |
| title | The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera |
| title_full | The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera |
| title_fullStr | The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera |
| title_full_unstemmed | The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera |
| title_short | The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera |
| title_sort | antiplasmodial activity of spermine alkaloids isolated from albizia gummifera |
| topic | albizia plasmodium drug plants alkaloids |
| url | https://hdl.handle.net/10568/28644 |
| work_keys_str_mv | AT rukungagm theantiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT muregifw theantiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT tolofm theantiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT omarsa theantiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT mwitarip theantiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT muthauracn theantiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT omlinf theantiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT lwandew theantiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT hassanalia theantiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT githurej theantiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT iraqifw theantiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT mungaigm theantiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT krausw theantiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT kofitsekpowm theantiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT rukungagm antiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT muregifw antiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT tolofm antiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT omarsa antiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT mwitarip antiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT muthauracn antiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT omlinf antiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT lwandew antiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT hassanalia antiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT githurej antiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT iraqifw antiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT mungaigm antiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT krausw antiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera AT kofitsekpowm antiplasmodialactivityofsperminealkaloidsisolatedfromalbiziagummifera |