Trypanosoma congolense: Proliferative responses and interleukin production in lymph node cells of infected cattle
T-cell-mediated immune responses to defined antigens of Trypanosoma congolense were measured in cattle undergoing primary infection. The antigens used were the variable surface glycoprotein and two invariant antigens, a 33-kDa cysteine protease (congopain) and a recombinant form of a 69-kDa heat-sho...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Elsevier
1995
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/28607 |
| _version_ | 1855518791014809600 |
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| author | Lutje, V. Mertens, B. Boulange, A.F. Williams, D.J.L. Authié, Edith |
| author_browse | Authié, Edith Boulange, A.F. Lutje, V. Mertens, B. Williams, D.J.L. |
| author_facet | Lutje, V. Mertens, B. Boulange, A.F. Williams, D.J.L. Authié, Edith |
| author_sort | Lutje, V. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | T-cell-mediated immune responses to defined antigens of Trypanosoma congolense were measured in cattle undergoing primary infection. The antigens used were the variable surface glycoprotein and two invariant antigens, a 33-kDa cysteine protease (congopain) and a recombinant form of a 69-kDa heat-shock protein. Proliferative responses were highest during the second week postinfection and were detected in cells obtained from the lymph node draining the site of infection but not in peripheral blood mononuclear cells. Production of IL-2 and IFN- was measured in supernatants from antigen-stimulated lymph node cell cultures. Expression of IL-2, IL-4, and IFN- mRNA was detected in antigen-stimulated lymph node cells by reverse transcription-polymerase chain amplification. |
| format | Journal Article |
| id | CGSpace28607 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1995 |
| publishDateRange | 1995 |
| publishDateSort | 1995 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace286072024-03-06T10:16:43Z Trypanosoma congolense: Proliferative responses and interleukin production in lymph node cells of infected cattle Lutje, V. Mertens, B. Boulange, A.F. Williams, D.J.L. Authié, Edith trypanosoma congolense interleukin infection cattle animal diseases immunology parasitology infectious diseases T-cell-mediated immune responses to defined antigens of Trypanosoma congolense were measured in cattle undergoing primary infection. The antigens used were the variable surface glycoprotein and two invariant antigens, a 33-kDa cysteine protease (congopain) and a recombinant form of a 69-kDa heat-shock protein. Proliferative responses were highest during the second week postinfection and were detected in cells obtained from the lymph node draining the site of infection but not in peripheral blood mononuclear cells. Production of IL-2 and IFN- was measured in supernatants from antigen-stimulated lymph node cell cultures. Expression of IL-2, IL-4, and IFN- mRNA was detected in antigen-stimulated lymph node cells by reverse transcription-polymerase chain amplification. 1995-09 2013-05-06T07:00:58Z 2013-05-06T07:00:58Z Journal Article https://hdl.handle.net/10568/28607 en Limited Access Elsevier Experimental Parasitology;81(2): 154-164 |
| spellingShingle | trypanosoma congolense interleukin infection cattle animal diseases immunology parasitology infectious diseases Lutje, V. Mertens, B. Boulange, A.F. Williams, D.J.L. Authié, Edith Trypanosoma congolense: Proliferative responses and interleukin production in lymph node cells of infected cattle |
| title | Trypanosoma congolense: Proliferative responses and interleukin production in lymph node cells of infected cattle |
| title_full | Trypanosoma congolense: Proliferative responses and interleukin production in lymph node cells of infected cattle |
| title_fullStr | Trypanosoma congolense: Proliferative responses and interleukin production in lymph node cells of infected cattle |
| title_full_unstemmed | Trypanosoma congolense: Proliferative responses and interleukin production in lymph node cells of infected cattle |
| title_short | Trypanosoma congolense: Proliferative responses and interleukin production in lymph node cells of infected cattle |
| title_sort | trypanosoma congolense proliferative responses and interleukin production in lymph node cells of infected cattle |
| topic | trypanosoma congolense interleukin infection cattle animal diseases immunology parasitology infectious diseases |
| url | https://hdl.handle.net/10568/28607 |
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