Alloreactive T-cell clones transformed by Theileria parva retain cytolytic activity and antigen specificity
Theileria parva is a protozoan parasite which infects and transforms bovine lymphocytes. This study examined the effects of Theileria‐induced transformation on phenotype and function, in terms of cytolytic potency and specificity, of class I and class II‐specific alloreactive T cell clones. Alloreac...
| Autores principales: | , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
1987
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/28553 |
| _version_ | 1855526434916794368 |
|---|---|
| author | Baldwin, Cynthia L. Teale, A.J. |
| author_browse | Baldwin, Cynthia L. Teale, A.J. |
| author_facet | Baldwin, Cynthia L. Teale, A.J. |
| author_sort | Baldwin, Cynthia L. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Theileria parva is a protozoan parasite which infects and transforms bovine lymphocytes. This study examined the effects of Theileria‐induced transformation on phenotype and function, in terms of cytolytic potency and specificity, of class I and class II‐specific alloreactive T cell clones. Alloreactive T cell clones infected with T. parva (Muguga) retained expression of the T cell differentiation antigens BoT2, BoT4, BoT8 and the mature T cell antigen recognized by monoclonal antibody ILA27, as well as cytolytic function and antigen specificity, over a period of 3–4 months in continuous culture. These features were identical to those expressed by the uninfected parent clones. During this period, neither antigenic stimulation nor exogenous growth factors were required for the maintenance of proliferation, function or antigen specificity. Thereafter, cytolytic activity declined and was eventually lost, which may reflect degenerative changes normally associated with T cell senescence rather than result from parasitization per se. |
| format | Journal Article |
| id | CGSpace28553 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1987 |
| publishDateRange | 1987 |
| publishDateSort | 1987 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace285532024-05-01T08:17:35Z Alloreactive T-cell clones transformed by Theileria parva retain cytolytic activity and antigen specificity Baldwin, Cynthia L. Teale, A.J. theileria parva clones lymphocytes antigens animal diseases Theileria parva is a protozoan parasite which infects and transforms bovine lymphocytes. This study examined the effects of Theileria‐induced transformation on phenotype and function, in terms of cytolytic potency and specificity, of class I and class II‐specific alloreactive T cell clones. Alloreactive T cell clones infected with T. parva (Muguga) retained expression of the T cell differentiation antigens BoT2, BoT4, BoT8 and the mature T cell antigen recognized by monoclonal antibody ILA27, as well as cytolytic function and antigen specificity, over a period of 3–4 months in continuous culture. These features were identical to those expressed by the uninfected parent clones. During this period, neither antigenic stimulation nor exogenous growth factors were required for the maintenance of proliferation, function or antigen specificity. Thereafter, cytolytic activity declined and was eventually lost, which may reflect degenerative changes normally associated with T cell senescence rather than result from parasitization per se. 1987 2013-05-06T07:00:52Z 2013-05-06T07:00:52Z Journal Article https://hdl.handle.net/10568/28553 en Limited Access Wiley European Journal of Immunology;17: 1859-1862 |
| spellingShingle | theileria parva clones lymphocytes antigens animal diseases Baldwin, Cynthia L. Teale, A.J. Alloreactive T-cell clones transformed by Theileria parva retain cytolytic activity and antigen specificity |
| title | Alloreactive T-cell clones transformed by Theileria parva retain cytolytic activity and antigen specificity |
| title_full | Alloreactive T-cell clones transformed by Theileria parva retain cytolytic activity and antigen specificity |
| title_fullStr | Alloreactive T-cell clones transformed by Theileria parva retain cytolytic activity and antigen specificity |
| title_full_unstemmed | Alloreactive T-cell clones transformed by Theileria parva retain cytolytic activity and antigen specificity |
| title_short | Alloreactive T-cell clones transformed by Theileria parva retain cytolytic activity and antigen specificity |
| title_sort | alloreactive t cell clones transformed by theileria parva retain cytolytic activity and antigen specificity |
| topic | theileria parva clones lymphocytes antigens animal diseases |
| url | https://hdl.handle.net/10568/28553 |
| work_keys_str_mv | AT baldwincynthial alloreactivetcellclonestransformedbytheileriaparvaretaincytolyticactivityandantigenspecificity AT tealeaj alloreactivetcellclonestransformedbytheileriaparvaretaincytolyticactivityandantigenspecificity |