Immune depresssion in trypanosome-infected mice. 2. Characterization of the spleen cell types involved
Spleen cells from Trypanosoma congolense‐infected mice showed a drastic depression in their capacity to respond to B and T lymphocyte mitogens and to allogeneic spleen cells in mixed lymphocyte cultures. Spleen cells from infected mice were also poor stimulators in mixed lymphocyte cultures. The poo...
| Autores principales: | , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
1979
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/28549 |
| _version_ | 1855527365349736448 |
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| author | Roelants, G.E. Pearson, T.W. Tyrer, H.W. Mayor-Withey, K.S. Lundin, L.B. |
| author_browse | Lundin, L.B. Mayor-Withey, K.S. Pearson, T.W. Roelants, G.E. Tyrer, H.W. |
| author_facet | Roelants, G.E. Pearson, T.W. Tyrer, H.W. Mayor-Withey, K.S. Lundin, L.B. |
| author_sort | Roelants, G.E. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Spleen cells from Trypanosoma congolense‐infected mice showed a drastic depression in their capacity to respond to B and T lymphocyte mitogens and to allogeneic spleen cells in mixed lymphocyte cultures. Spleen cells from infected mice were also poor stimulators in mixed lymphocyte cultures. The poor responsiveness or stimulation capacity was not due simply to dilution of relevant B or T lymphocytes by the large number of null cells found in the spleens of infected animals. These null cells expressed approximately eight times more H‐2 antigen than spleen cells from normal (uninfected) mice and were devoid of Ia antigens. |
| format | Journal Article |
| id | CGSpace28549 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1979 |
| publishDateRange | 1979 |
| publishDateSort | 1979 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace285492024-05-01T08:17:42Z Immune depresssion in trypanosome-infected mice. 2. Characterization of the spleen cell types involved Roelants, G.E. Pearson, T.W. Tyrer, H.W. Mayor-Withey, K.S. Lundin, L.B. immune response mice trypanosoma lymphocytes animal diseases disease control Spleen cells from Trypanosoma congolense‐infected mice showed a drastic depression in their capacity to respond to B and T lymphocyte mitogens and to allogeneic spleen cells in mixed lymphocyte cultures. Spleen cells from infected mice were also poor stimulators in mixed lymphocyte cultures. The poor responsiveness or stimulation capacity was not due simply to dilution of relevant B or T lymphocytes by the large number of null cells found in the spleens of infected animals. These null cells expressed approximately eight times more H‐2 antigen than spleen cells from normal (uninfected) mice and were devoid of Ia antigens. 1979-03 2013-05-06T07:00:51Z 2013-05-06T07:00:51Z Journal Article https://hdl.handle.net/10568/28549 en Limited Access Wiley European Journal of Immunology;9: 195-199 |
| spellingShingle | immune response mice trypanosoma lymphocytes animal diseases disease control Roelants, G.E. Pearson, T.W. Tyrer, H.W. Mayor-Withey, K.S. Lundin, L.B. Immune depresssion in trypanosome-infected mice. 2. Characterization of the spleen cell types involved |
| title | Immune depresssion in trypanosome-infected mice. 2. Characterization of the spleen cell types involved |
| title_full | Immune depresssion in trypanosome-infected mice. 2. Characterization of the spleen cell types involved |
| title_fullStr | Immune depresssion in trypanosome-infected mice. 2. Characterization of the spleen cell types involved |
| title_full_unstemmed | Immune depresssion in trypanosome-infected mice. 2. Characterization of the spleen cell types involved |
| title_short | Immune depresssion in trypanosome-infected mice. 2. Characterization of the spleen cell types involved |
| title_sort | immune depresssion in trypanosome infected mice 2 characterization of the spleen cell types involved |
| topic | immune response mice trypanosoma lymphocytes animal diseases disease control |
| url | https://hdl.handle.net/10568/28549 |
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