Immune depression in trypanosome-infected mice. 3. Suppressor cell
Spleen cells from trypanosome‐infected mice strongly suppressed lymphocyte stimulation induced in normal spleen cell populations by lipopolysaccharide, concanavalin A or allogeneic (H‐2‐different) stimulator cells. This suppression was not H‐2‐restricted, as responses of spleen lymphocytes both allo...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Wiley
1979
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/28547 |
| _version_ | 1855514486388031488 |
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| author | Pearson, T.W. Roelants, G.E. Pinder, M. Lundin, L.B. Mayor-Withey, K.S. |
| author_browse | Lundin, L.B. Mayor-Withey, K.S. Pearson, T.W. Pinder, M. Roelants, G.E. |
| author_facet | Pearson, T.W. Roelants, G.E. Pinder, M. Lundin, L.B. Mayor-Withey, K.S. |
| author_sort | Pearson, T.W. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Spleen cells from trypanosome‐infected mice strongly suppressed lymphocyte stimulation induced in normal spleen cell populations by lipopolysaccharide, concanavalin A or allogeneic (H‐2‐different) stimulator cells. This suppression was not H‐2‐restricted, as responses of spleen lymphocytes both allogeneic and syngeneic to the suppressors were inhibited. Irradiation or mitomycin C treatment of suppressor populations markedly reduced but did not eliminate suppressor activity. Suppressor populations were effective when present in very low numbers. Addition of suppressor cells to mixed lymphocyte cultures at various intervals after initiation of the cultures showed that the suppressors require 48 h to manifest their activity. Cell depletion or enrichment experiments indicate that the mechanism of suppression is complex and involves more than one cell type. |
| format | Journal Article |
| id | CGSpace28547 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1979 |
| publishDateRange | 1979 |
| publishDateSort | 1979 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace285472024-05-01T08:15:18Z Immune depression in trypanosome-infected mice. 3. Suppressor cell Pearson, T.W. Roelants, G.E. Pinder, M. Lundin, L.B. Mayor-Withey, K.S. immune response trypanosoma mice lymphocytes disease control animal diseases immunology Spleen cells from trypanosome‐infected mice strongly suppressed lymphocyte stimulation induced in normal spleen cell populations by lipopolysaccharide, concanavalin A or allogeneic (H‐2‐different) stimulator cells. This suppression was not H‐2‐restricted, as responses of spleen lymphocytes both allogeneic and syngeneic to the suppressors were inhibited. Irradiation or mitomycin C treatment of suppressor populations markedly reduced but did not eliminate suppressor activity. Suppressor populations were effective when present in very low numbers. Addition of suppressor cells to mixed lymphocyte cultures at various intervals after initiation of the cultures showed that the suppressors require 48 h to manifest their activity. Cell depletion or enrichment experiments indicate that the mechanism of suppression is complex and involves more than one cell type. 1979-03 2013-05-06T07:00:50Z 2013-05-06T07:00:50Z Journal Article https://hdl.handle.net/10568/28547 en Limited Access Wiley European Journal of Immunology;9: 200-204 |
| spellingShingle | immune response trypanosoma mice lymphocytes disease control animal diseases immunology Pearson, T.W. Roelants, G.E. Pinder, M. Lundin, L.B. Mayor-Withey, K.S. Immune depression in trypanosome-infected mice. 3. Suppressor cell |
| title | Immune depression in trypanosome-infected mice. 3. Suppressor cell |
| title_full | Immune depression in trypanosome-infected mice. 3. Suppressor cell |
| title_fullStr | Immune depression in trypanosome-infected mice. 3. Suppressor cell |
| title_full_unstemmed | Immune depression in trypanosome-infected mice. 3. Suppressor cell |
| title_short | Immune depression in trypanosome-infected mice. 3. Suppressor cell |
| title_sort | immune depression in trypanosome infected mice 3 suppressor cell |
| topic | immune response trypanosoma mice lymphocytes disease control animal diseases immunology |
| url | https://hdl.handle.net/10568/28547 |
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