Characterisation of a heparan sulfate proteoglycan homologue OVPG-1 from Onchocerca volvulus
Objective: To determine the role of an immunodominant antigen OvPG-1 in human onchocerciasis. Design: Cross-sectional study of subjects living in three onchocerciasis endemic areas. Setting: Mbonge and Tubah divisions of Western Cameroon and in Esmeralda Province of Ecuador. Subjects: There were 94...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
2005
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| Online Access: | https://hdl.handle.net/10568/28474 |
| _version_ | 1855536007885094912 |
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| author | Amambua, A.N. Tachu, J.B. Ghogomu, S.M. Pelle, Roger Titanji, V.P.K. |
| author_browse | Amambua, A.N. Ghogomu, S.M. Pelle, Roger Tachu, J.B. Titanji, V.P.K. |
| author_facet | Amambua, A.N. Tachu, J.B. Ghogomu, S.M. Pelle, Roger Titanji, V.P.K. |
| author_sort | Amambua, A.N. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Objective: To determine the role of an immunodominant antigen OvPG-1 in human onchocerciasis. Design: Cross-sectional study of subjects living in three onchocerciasis endemic areas. Setting: Mbonge and Tubah divisions of Western Cameroon and in Esmeralda Province of Ecuador. Subjects: There were 94 and 99 subjects from the Cameroon rain forest and savannah respectively, and 83 endemic residents from Ecuador. Results: The IgG2 anti-OvPG-1 responses of visually impaired and microfiladermic patients were significantly higher than for their age and sex matched counterparts with normal vision and no microfiladermia (p=0.024). Furthermore, the isotype specificity of anti-OvPG-I responses varied for the various onchocerciasis endemic zones. IgGl, IgG2, IgG3 and IgE levels correlated with the presence of microfilariae in Cameroon, but not in Ecuador. Conclusion: Increased IgG and IgE levels to the antigen OvPG-1 seem to correlate with the development of onchocercal eye pathology. The present results suggest that the OvPG1 is a dominant antigen of Onchocerca volvulus with a significant role in the pathogenesis of onchocerciasis. |
| format | Journal Article |
| id | CGSpace28474 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2005 |
| publishDateRange | 2005 |
| publishDateSort | 2005 |
| record_format | dspace |
| spelling | CGSpace284742023-02-15T10:08:52Z Characterisation of a heparan sulfate proteoglycan homologue OVPG-1 from Onchocerca volvulus Amambua, A.N. Tachu, J.B. Ghogomu, S.M. Pelle, Roger Titanji, V.P.K. onchocerca volvulus sulphates proteoglycans [glycoproteins] antigens pathology mankind endemics pathogenesis Objective: To determine the role of an immunodominant antigen OvPG-1 in human onchocerciasis. Design: Cross-sectional study of subjects living in three onchocerciasis endemic areas. Setting: Mbonge and Tubah divisions of Western Cameroon and in Esmeralda Province of Ecuador. Subjects: There were 94 and 99 subjects from the Cameroon rain forest and savannah respectively, and 83 endemic residents from Ecuador. Results: The IgG2 anti-OvPG-1 responses of visually impaired and microfiladermic patients were significantly higher than for their age and sex matched counterparts with normal vision and no microfiladermia (p=0.024). Furthermore, the isotype specificity of anti-OvPG-I responses varied for the various onchocerciasis endemic zones. IgGl, IgG2, IgG3 and IgE levels correlated with the presence of microfilariae in Cameroon, but not in Ecuador. Conclusion: Increased IgG and IgE levels to the antigen OvPG-1 seem to correlate with the development of onchocercal eye pathology. The present results suggest that the OvPG1 is a dominant antigen of Onchocerca volvulus with a significant role in the pathogenesis of onchocerciasis. 2005 2013-05-06T07:00:40Z 2013-05-06T07:00:40Z Journal Article https://hdl.handle.net/10568/28474 en Limited Access East African Medical Journal;82(12): 614-624 |
| spellingShingle | onchocerca volvulus sulphates proteoglycans [glycoproteins] antigens pathology mankind endemics pathogenesis Amambua, A.N. Tachu, J.B. Ghogomu, S.M. Pelle, Roger Titanji, V.P.K. Characterisation of a heparan sulfate proteoglycan homologue OVPG-1 from Onchocerca volvulus |
| title | Characterisation of a heparan sulfate proteoglycan homologue OVPG-1 from Onchocerca volvulus |
| title_full | Characterisation of a heparan sulfate proteoglycan homologue OVPG-1 from Onchocerca volvulus |
| title_fullStr | Characterisation of a heparan sulfate proteoglycan homologue OVPG-1 from Onchocerca volvulus |
| title_full_unstemmed | Characterisation of a heparan sulfate proteoglycan homologue OVPG-1 from Onchocerca volvulus |
| title_short | Characterisation of a heparan sulfate proteoglycan homologue OVPG-1 from Onchocerca volvulus |
| title_sort | characterisation of a heparan sulfate proteoglycan homologue ovpg 1 from onchocerca volvulus |
| topic | onchocerca volvulus sulphates proteoglycans [glycoproteins] antigens pathology mankind endemics pathogenesis |
| url | https://hdl.handle.net/10568/28474 |
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