Monoclonal antibody binding to a surface exposed epitope on Cowdria ruminantium that is conserved among light strains

Monoclonal antibodies (MAb) binding to Cowdria ruminantium elementary bodies (CB) were identified by enzyme-linked immunosorbent assay, and surface binding of one MAb (446.15) to intact CB was determined by immunofluorescence, immunogold labeling, and transmission electron microscopy. MAb 446.15 bou...

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Main Authors: Shompole, S., Rurangirwa, F.R., Wambugu, J., Sitienei, J., Mwangi, David Miano, Musoke, A.J., Mahan, S., Wells, C.W., McGuire, T.C.
Format: Journal Article
Language:Inglés
Published: 2000
Subjects:
Online Access:https://hdl.handle.net/10568/28415
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author Shompole, S.
Rurangirwa, F.R.
Wambugu, J.
Sitienei, J.
Mwangi, David Miano
Musoke, A.J.
Mahan, S.
Wells, C.W.
McGuire, T.C.
author_browse Mahan, S.
McGuire, T.C.
Musoke, A.J.
Mwangi, David Miano
Rurangirwa, F.R.
Shompole, S.
Sitienei, J.
Wambugu, J.
Wells, C.W.
author_facet Shompole, S.
Rurangirwa, F.R.
Wambugu, J.
Sitienei, J.
Mwangi, David Miano
Musoke, A.J.
Mahan, S.
Wells, C.W.
McGuire, T.C.
author_sort Shompole, S.
collection Repository of Agricultural Research Outputs (CGSpace)
description Monoclonal antibodies (MAb) binding to Cowdria ruminantium elementary bodies (CB) were identified by enzyme-linked immunosorbent assay, and surface binding of one MAb (446.15) to intact CB was determined by immunofluorescence, immunogold labeling, and transmission electron microscopy. MAb 446.15 bound an antigen of approximately 43 kDa in immunoblots of eight geographically distinct strains. The NIAb did not react with Ehrlichia canis antigens or uninfected bovine endothelial cell lysate and may be useful in diagnostic assays and vaccine development.
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spelling CGSpace284152024-03-06T10:16:43Z Monoclonal antibody binding to a surface exposed epitope on Cowdria ruminantium that is conserved among light strains Shompole, S. Rurangirwa, F.R. Wambugu, J. Sitienei, J. Mwangi, David Miano Musoke, A.J. Mahan, S. Wells, C.W. McGuire, T.C. monoclonal antibodies cowdria ruminantium antigenes Monoclonal antibodies (MAb) binding to Cowdria ruminantium elementary bodies (CB) were identified by enzyme-linked immunosorbent assay, and surface binding of one MAb (446.15) to intact CB was determined by immunofluorescence, immunogold labeling, and transmission electron microscopy. MAb 446.15 bound an antigen of approximately 43 kDa in immunoblots of eight geographically distinct strains. The NIAb did not react with Ehrlichia canis antigens or uninfected bovine endothelial cell lysate and may be useful in diagnostic assays and vaccine development. 2000 2013-05-06T07:00:34Z 2013-05-06T07:00:34Z Journal Article https://hdl.handle.net/10568/28415 en Limited Access Clinical and Diagnostic Laboratory Immunology;7(6): 983-986
spellingShingle monoclonal antibodies
cowdria ruminantium
antigenes
Shompole, S.
Rurangirwa, F.R.
Wambugu, J.
Sitienei, J.
Mwangi, David Miano
Musoke, A.J.
Mahan, S.
Wells, C.W.
McGuire, T.C.
Monoclonal antibody binding to a surface exposed epitope on Cowdria ruminantium that is conserved among light strains
title Monoclonal antibody binding to a surface exposed epitope on Cowdria ruminantium that is conserved among light strains
title_full Monoclonal antibody binding to a surface exposed epitope on Cowdria ruminantium that is conserved among light strains
title_fullStr Monoclonal antibody binding to a surface exposed epitope on Cowdria ruminantium that is conserved among light strains
title_full_unstemmed Monoclonal antibody binding to a surface exposed epitope on Cowdria ruminantium that is conserved among light strains
title_short Monoclonal antibody binding to a surface exposed epitope on Cowdria ruminantium that is conserved among light strains
title_sort monoclonal antibody binding to a surface exposed epitope on cowdria ruminantium that is conserved among light strains
topic monoclonal antibodies
cowdria ruminantium
antigenes
url https://hdl.handle.net/10568/28415
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