Resistance to trypanosomosis: Of markers, genes and mechanisms
A two species comparative genome scanning approach has been taken to mapping, and eventually identifying, genes at quantitative trait loci (QTL) influencing resistance to trypanosomosis due to infection with Trypanosoma congolense. Using two large murine F2 and two F6 advanced intercross populations...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Language: | Inglés |
| Published: |
1999
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/28360 |
| _version_ | 1855533735250755584 |
|---|---|
| author | Teale, A.J. Agaba, Morris Clapcott, S.J. Gelhaus, A. Haley, C. Psifidis, A. Horstmann, R. Iraqui, F. Kemp, Stephen J. Nilsson, P. Schwerin, M. Sekikawa, K. Soller, M. Sugimoto, Y. Womack, J. |
| author_browse | Agaba, Morris Clapcott, S.J. Gelhaus, A. Haley, C. Horstmann, R. Iraqui, F. Kemp, Stephen J. Nilsson, P. Psifidis, A. Schwerin, M. Sekikawa, K. Soller, M. Sugimoto, Y. Teale, A.J. Womack, J. |
| author_facet | Teale, A.J. Agaba, Morris Clapcott, S.J. Gelhaus, A. Haley, C. Psifidis, A. Horstmann, R. Iraqui, F. Kemp, Stephen J. Nilsson, P. Schwerin, M. Sekikawa, K. Soller, M. Sugimoto, Y. Womack, J. |
| author_sort | Teale, A.J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | A two species comparative genome scanning approach has been taken to mapping, and eventually identifying, genes at quantitative trait loci (QTL) influencing resistance to trypanosomosis due to infection with Trypanosoma congolense. Using two large murine F2 and two F6 advanced intercross populations, QTL influencing survival time in mice following challenge with T. congolense were mapped to small confidence intervals on MMU1, 5 and 17. The QTL on MMU17, Tirl, has a sufficiently small confidence interval (<1cM) to justify an immediate search for positional candidate genes at the DNA level. Mapping of trypanotolerance loci in an F2 cattle resource population is now beginning to reveal bovine resistance QTLs. A key strength of the comparative strategy derives from overlaying the genetic maps of murine and bovine QTL - containing regions. If, and where, the same genes are used by the two species, this may facilitate localisation of one or more of the genes contributing to variation in resistance to T. congolense trypanosomosis. |
| format | Journal Article |
| id | CGSpace28360 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1999 |
| publishDateRange | 1999 |
| publishDateSort | 1999 |
| record_format | dspace |
| spelling | CGSpace283602023-04-20T00:29:35Z Resistance to trypanosomosis: Of markers, genes and mechanisms Teale, A.J. Agaba, Morris Clapcott, S.J. Gelhaus, A. Haley, C. Psifidis, A. Horstmann, R. Iraqui, F. Kemp, Stephen J. Nilsson, P. Schwerin, M. Sekikawa, K. Soller, M. Sugimoto, Y. Womack, J. trypanosomiasis disease resistance genes genetic markers genetic maps A two species comparative genome scanning approach has been taken to mapping, and eventually identifying, genes at quantitative trait loci (QTL) influencing resistance to trypanosomosis due to infection with Trypanosoma congolense. Using two large murine F2 and two F6 advanced intercross populations, QTL influencing survival time in mice following challenge with T. congolense were mapped to small confidence intervals on MMU1, 5 and 17. The QTL on MMU17, Tirl, has a sufficiently small confidence interval (<1cM) to justify an immediate search for positional candidate genes at the DNA level. Mapping of trypanotolerance loci in an F2 cattle resource population is now beginning to reveal bovine resistance QTLs. A key strength of the comparative strategy derives from overlaying the genetic maps of murine and bovine QTL - containing regions. If, and where, the same genes are used by the two species, this may facilitate localisation of one or more of the genes contributing to variation in resistance to T. congolense trypanosomosis. 1999 2013-05-06T07:00:27Z 2013-05-06T07:00:27Z Journal Article https://hdl.handle.net/10568/28360 en Limited Access Archiv fur Tierzucht - Special Issue;42: 36-41 |
| spellingShingle | trypanosomiasis disease resistance genes genetic markers genetic maps Teale, A.J. Agaba, Morris Clapcott, S.J. Gelhaus, A. Haley, C. Psifidis, A. Horstmann, R. Iraqui, F. Kemp, Stephen J. Nilsson, P. Schwerin, M. Sekikawa, K. Soller, M. Sugimoto, Y. Womack, J. Resistance to trypanosomosis: Of markers, genes and mechanisms |
| title | Resistance to trypanosomosis: Of markers, genes and mechanisms |
| title_full | Resistance to trypanosomosis: Of markers, genes and mechanisms |
| title_fullStr | Resistance to trypanosomosis: Of markers, genes and mechanisms |
| title_full_unstemmed | Resistance to trypanosomosis: Of markers, genes and mechanisms |
| title_short | Resistance to trypanosomosis: Of markers, genes and mechanisms |
| title_sort | resistance to trypanosomosis of markers genes and mechanisms |
| topic | trypanosomiasis disease resistance genes genetic markers genetic maps |
| url | https://hdl.handle.net/10568/28360 |
| work_keys_str_mv | AT tealeaj resistancetotrypanosomosisofmarkersgenesandmechanisms AT agabamorris resistancetotrypanosomosisofmarkersgenesandmechanisms AT clapcottsj resistancetotrypanosomosisofmarkersgenesandmechanisms AT gelhausa resistancetotrypanosomosisofmarkersgenesandmechanisms AT haleyc resistancetotrypanosomosisofmarkersgenesandmechanisms AT psifidisa resistancetotrypanosomosisofmarkersgenesandmechanisms AT horstmannr resistancetotrypanosomosisofmarkersgenesandmechanisms AT iraquif resistancetotrypanosomosisofmarkersgenesandmechanisms AT kempstephenj resistancetotrypanosomosisofmarkersgenesandmechanisms AT nilssonp resistancetotrypanosomosisofmarkersgenesandmechanisms AT schwerinm resistancetotrypanosomosisofmarkersgenesandmechanisms AT sekikawak resistancetotrypanosomosisofmarkersgenesandmechanisms AT sollerm resistancetotrypanosomosisofmarkersgenesandmechanisms AT sugimotoy resistancetotrypanosomosisofmarkersgenesandmechanisms AT womackj resistancetotrypanosomosisofmarkersgenesandmechanisms |